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AGRN(30-2045) [extracellular region]
Stable Identifier
R-HSA-375056
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
AGRN, Agrin, AGRIN_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
NCAM signaling for neurite out-growth (Homo sapiens)
NCAM1 interactions (Homo sapiens)
Interaction of NCAM1 with agrin (Homo sapiens)
AGRN(30-2045) [extracellular region] (Homo sapiens)
NCAM-1:Agrin [plasma membrane] (Homo sapiens)
AGRN(30-2045) [extracellular region] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
ECM proteoglycans (Homo sapiens)
AGRN binds Alpha-dystroglycan (Homo sapiens)
AGRN(30-2045) [extracellular region] (Homo sapiens)
AGRN:Alpha-dystroglycan [extracellular region] (Homo sapiens)
AGRN(30-2045) [extracellular region] (Homo sapiens)
AGRN binds Beta amyloid fibril via GAG chains (Homo sapiens)
AGRN(30-2045) [extracellular region] (Homo sapiens)
AGRN:Beta amyloid fibril [extracellular region] (Homo sapiens)
AGRN(30-2045) [extracellular region] (Homo sapiens)
AGRN binds LRP4:MUSK (Homo sapiens)
AGRN(30-2045) [extracellular region] (Homo sapiens)
AGRN:LRP4:MUSK [plasma membrane] (Homo sapiens)
AGRN(30-2045) [extracellular region] (Homo sapiens)
AGRN binds Laminins with gamma-1 subunit (Homo sapiens)
AGRN(30-2045) [extracellular region] (Homo sapiens)
AGRN:Laminins with gamma-1 [extracellular region] (Homo sapiens)
AGRN(30-2045) [extracellular region] (Homo sapiens)
AGRN binds NCAM1, PTPRS (Homo sapiens)
AGRN(30-2045) [extracellular region] (Homo sapiens)
AGRN:NCAM1, PTPRS [plasma membrane] (Homo sapiens)
AGRN(30-2045) [extracellular region] (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
AGRN binds Integrins alphaVbeta1 (Other beta1-containing integrins) (Homo sapiens)
AGRN(30-2045) [extracellular region] (Homo sapiens)
Agrin:Integrin alphaVbeta1 (other beta1) [plasma membrane] (Homo sapiens)
AGRN(30-2045) [extracellular region] (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Dystroglycan binds AGRN and HSPG2 (Homo sapiens)
AGRN, HSPG2 [extracellular region] (Homo sapiens)
AGRN(30-2045) [extracellular region] (Homo sapiens)
Dystroglycan:AGRN:HSPG2 [plasma membrane] (Homo sapiens)
AGRN, HSPG2 [extracellular region] (Homo sapiens)
AGRN(30-2045) [extracellular region] (Homo sapiens)
Formation of the dystrophin-glycoprotein complex (DGC) (Homo sapiens)
DGC complex binds AGRN and HSPG2 (Homo sapiens)
AGRN, HSPG2 [extracellular region] (Homo sapiens)
AGRN(30-2045) [extracellular region] (Homo sapiens)
DGC complex:laminins:F-actin:AGRN,HSPG2 [plasma membrane] (Homo sapiens)
AGRN, HSPG2 [extracellular region] (Homo sapiens)
AGRN(30-2045) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00468 AGRN
Gene Names
AGRN, AGRIN
Chain
signal peptide:1-29, chain:30-2068, chain:30-1102, chain:1103-2068, chain:1103-1863, chain:1864-2068
Reference Genes
COSMIC (genes):AGRN O004686
dbSNP Gene:375790 O004686
ENSEMBL:ENSG00000188157 AGRN
Participates
as a component of
AGRN:Laminins with gamma-1 [extracellular region] (Homo sapiens)
AGRN:Beta amyloid fibril [extracellular region] (Homo sapiens)
AGRN:LRP4:MUSK [plasma membrane] (Homo sapiens)
AGRN:NCAM1, PTPRS [plasma membrane] (Homo sapiens)
AGRN:Alpha-dystroglycan [extracellular region] (Homo sapiens)
Agrin:Integrins alphaVbeta1 (alpha1beta1) [plasma membrane] (Gallus gallus)
Agrin:Integrin alphaVbeta1 (other beta1) [plasma membrane] (Homo sapiens)
NCAM-1:Agrin [plasma membrane] (Homo sapiens)
as an input of
AGRN binds Laminins with gamma-1 subunit (Homo sapiens)
AGRN binds Beta amyloid fibril via GAG chains (Homo sapiens)
AGRN binds LRP4:MUSK (Homo sapiens)
AGRN binds NCAM1, PTPRS (Homo sapiens)
AGRN binds Alpha-dystroglycan (Homo sapiens)
Agrin binds Integrin alphaVbeta1 (alpha1beta1) (Gallus gallus)
AGRN binds Integrins alphaVbeta1 (Other beta1-containing integrins) (Homo sapiens)
Interaction of NCAM1 with agrin (Homo sapiens)
as a member of
AGRN, HSPG2 [extracellular region] (Homo sapiens)
Other forms of this molecule
HS(4)-AGRN [plasma membrane]
HS(6)-AGRN [plasma membrane]
HS(2)-AGRN [plasma membrane]
HS(1)-AGRN [plasma membrane]
HS(3)-AGRN [plasma membrane]
HS(5)-AGRN [plasma membrane]
XylS-AGRN(30-2045) [Golgi lumen]
Gal-Xyl-AGRN [Golgi lumen]
AGRN(30-2045) [Golgi lumen]
Gal-Gal-Xyl-AGRN [Golgi lumen]
GlcA-Gal-Gal-Xyl-AGRN [Golgi lumen]
HS(3)-AGRN [Golgi lumen]
HS(4)-AGRN [Golgi lumen]
HS(2)-AGRN [Golgi lumen]
HS(1)-AGRN [Golgi lumen]
Heparan(4)-AGRN [Golgi lumen]
Heparan(3)-AGRN [Golgi lumen]
Heparan(2)-AGRN [Golgi lumen]
Heparan(1)-AGRN [Golgi lumen]
Heparan-AGRN [Golgi lumen]
HS(5)-AGRN [Golgi lumen]
HS(6)-AGRN [Golgi lumen]
HS(6)-AGRN [lysosomal lumen]
AGRN(30-2045) [lysosomal lumen]
Inferred To
itx-1 [extracellular region]
(Caenorhabditis elegans)
AGRN [extracellular region]
(Bos taurus)
AGRN [extracellular region]
(Canis familiaris)
AGRN [extracellular region]
(Sus scrofa)
AGRN(30-2045) [extracellular region]
(Caenorhabditis elegans)
AGRN(30-2045) [extracellular region]
(Mus musculus)
AGRN(30-2045) [extracellular region]
(Rattus norvegicus)
Homologues of AGRN(30-2045) [extracellular region]
(Caenorhabditis elegans)
SP2353 [extracellular region]
(Drosophila melanogaster)
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15530 PDPK1
3
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.527
2
UniProt:Q13438 OS9
1
OS9 [endoplasmic reticulum membrane]
(R-HSA-1022132)
0.527
3
UniProt:P02741 CRP
1
CRP(19-224) [extracellular region]
(R-HSA-976719)
0.527
3
UniProt:O15265 ATXN7
2
ATXN7 [nucleoplasm]
(R-HSA-8869458)
ATXN7 [cytosol]
(R-HSA-201591)
0.508
2
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