Reactome | ATP1B1 [plasma membrane]

ATP1B1 [plasma membrane]

Stable Identifier

R-HSA-375071

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Sodium/potassium-transporting ATPase subunit beta-1, AT1B1_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        ATP1A:ATP1B:FXYD binds cardiac glycosides (Homo sapiens)
        
        ATP1A:ATP1B:FXYD [plasma membrane] (Homo sapiens)
        
        ATP1B [plasma membrane] (Homo sapiens)
        
        ATP1B1 [plasma membrane] (Homo sapiens)
        
        ATP1A:ATP1B:FXYD:cardiac glycosides [plasma membrane] (Homo sapiens)
        
        ATP1A:ATP1B:FXYD [plasma membrane] (Homo sapiens)
        
        ATP1B [plasma membrane] (Homo sapiens)
        
        ATP1B1 [plasma membrane] (Homo sapiens)

Hemostasis (Homo sapiens)

- Cell surface interactions at the vascular wall (Homo sapiens)
  - Basigin interactions (Homo sapiens)
    - Basigin binds Mannose-carrying cell recognition molecules (Homo sapiens)
      - Basigin:Mannose-carrying cell recognition molecules [plasma membrane] (Homo sapiens)
        
        Mannose-carrying cell recognition molecules [plasma membrane] (Homo sapiens)
        
        Sodium/potassium-transporting ATPase beta subunit [plasma membrane] (Homo sapiens)
        
        ATP1B1 [plasma membrane] (Homo sapiens)
      - Mannose-carrying cell recognition molecules [plasma membrane] (Homo sapiens)
        
        Sodium/potassium-transporting ATPase beta subunit [plasma membrane] (Homo sapiens)
        
        ATP1B1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P05026 ATP1B1

Gene Names

ATP1B1, ATP1B

Chain

chain:1-303

Reference Genes

BioGPS Gene:481 ATP1B1

COSMIC (genes):ATP1B1 ATP1B1

CTD Gene:481 ATP1B1

dbSNP Gene:481 ATP1B1

ENSEMBL:ENSG00000143153 ATP1B1

ENSEMBL_homo_sapiens_GENE:ENSG00000143153.14 ATP1B1

HGNC:804 ATP1B1

KEGG Gene (Homo sapiens):481 ATP1B1

Monarch:481 ATP1B1

NCBI Gene:481 ATP1B1

OMIM:182330 ATP1B1

UCSC:P05026 ATP1B1

Reference Transcript

RefSeq:NM_001677.3 ATP1B1

Other Identifiers

11726271_a_at

11726272_a_at

11746991_a_at

16673525

201242_PM_s_at

201242_s_at

201243_PM_s_at

201243_s_at

2366421

2366423

2366424

2366425

2366432

2366443

2366446

2366447

2366451

2366452

2366454

2366455

2366456

2366457

2366458

2366459

2366460

2366462

37669_s_at

481

7907160

A_23_P62932

GE59655

GO:0001671

GO:0002376

GO:0003012

GO:0003013

GO:0005215

GO:0005391

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0005890

GO:0005929

GO:0006811

GO:0006813

GO:0006814

GO:0006874

GO:0006883

GO:0006886

GO:0007155

GO:0010248

GO:0010468

GO:0010882

GO:0014704

GO:0016020

GO:0016323

GO:0016324

GO:0016328

GO:0019901

GO:0023026

GO:0023052

GO:0030007

GO:0030315

GO:0030674

GO:0031090

GO:0032781

GO:0035725

GO:0036126

GO:0036376

GO:0042383

GO:0043226

GO:0044861

GO:0045087

GO:0046034

GO:0046982

GO:0050821

GO:0051117

GO:0055065

GO:0055085

GO:0055086

GO:0055119

GO:0060048

GO:0060090

GO:0061024

GO:0070062

GO:0072659

GO:0086009

GO:0086013

GO:0086064

GO:0098542

GO:0098655

GO:0098772

GO:0140657

GO:1901018

GO:1901135

GO:1902600

GO:1903169

GO:1903278

GO:1903281

GO:1903288

GO:1903408

GO:1903561

GO:1990573

HMNXSV003001430

ILMN_1658071

ILMN_1730291

ILMN_2407824

PH_hs_0028990

PH_hs_0032423

TC01001473.hg

U16799_s_at

g12652534_3p_a_at

g4502276_3p_a_at

Participates

as a member of

ATP1B [plasma membrane] (Homo sapiens)

as a component of

Sodium/potassium-transporting ATPase beta subunit [plasma membrane] (Homo sapiens)

Inferred To

nkb-3 [plasma membrane] (Caenorhabditis elegans)

nrv3 [plasma membrane] (Drosophila melanogaster)

nrv2 [plasma membrane] (Drosophila melanogaster)

Homologues of ATP1B1 [plasma membrane] (Caenorhabditis elegans)

Homologues of ATP1B1 [plasma membrane] (Drosophila melanogaster)

ATP1B1 [plasma membrane] (Bos taurus)

ATP1B1 [plasma membrane] (Canis familiaris)

ATP1B1 [plasma membrane] (Gallus gallus)

ATP1B1 [plasma membrane] (Sus scrofa)

Atp1b1 [plasma membrane] (Mus musculus)

Atp1b1 [plasma membrane] (Rattus norvegicus)

JYbeta2 [plasma membrane] (Drosophila melanogaster)

nkb-1 [plasma membrane] (Caenorhabditis elegans)

atp1b1 [plasma membrane] (Xenopus tropicalis)

Dmel\CG5250 [plasma membrane] (Drosophila melanogaster)

atp1b1b [plasma membrane] (Danio rerio)

Dmel\CG33310 [plasma membrane] (Drosophila melanogaster)

nkb-2 [plasma membrane] (Caenorhabditis elegans)

nrv1 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001668.1

Guide to Pharmacology - Targets

837

OpenTargets

ENSG00000143153

GeneCards

P05026

HPA

ENSG00000143153-ATP1B1

Ensembl

ENSP00000356789, ENSP00000356790, ENSP00000509517, ENSG00000143153, ENST00000367815, ENST00000367816, ENSP00000509039, ENST00000690184, ENST00000689522

PRO

P05026

Pharos - Targets

P05026

HMDB Protein

HMDBP01228

PDB

8D3U, 8D3W, 8D3Y, 7E20, 8D3V, 8D3X, 7E1Z, 7E21

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.643	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.581	6
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P30556 AGTR1	2	AGTR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869071) AGTR1 [plasma membrane] (R-HSA-374247)	0.508	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	7
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.462	2

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