Reactome | Amine ligand-binding receptors

Amine ligand-binding receptors

Stable Identifier

R-HSA-375280

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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The class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine) can all act as neurotransmitters in humans. The so-called 'trace amines', used when referring to p-tyramine, beta-phenylethylamine, tryptamine and octopamine, can also bind to recently-discovered GPCRs.

Literature References

PubMed ID	Title	Journal	Year
15148138	The neurobiology of dopamine signaling Girault, JA, Greengard, P	Arch Neurol	2004
17073660	Muscarinic acetylcholine receptors Ishii, M, Kurachi, Y	Curr Pharm Des	2006
17897004	5-hydroxytryptamine (5-HT) receptor ligands Kitson, SL	Curr Pharm Des	2007
7938162	International Union of Pharmacology nomenclature of adrenoceptors Molinoff, PB, Eikenberg, DC, Ruffolo RR, Jr, Lefkowitz, RJ, Hieble, JP, Bylund, DB, Minneman, KP, Trendelenburg, U, Langer, SZ	Pharmacol Rev	1994
11459929	Trace amines: identification of a family of mammalian G protein-coupled receptors Lichtblau, H, Bonini, JA, Jones, KA, Branchek, TA, Borowsky, B, Pu, X, Artymyshyn, R, Boyle, N, Pathirana, S, Ochoa, FY, Gerald, C, Ogozalek, KL, Kouranova, E, Raddatz, R, Adham, N, Durkin, MM, Lakhlani, PP	Proc Natl Acad Sci U S A	2001
9311023	International Union of Pharmacology. XIII. Classification of histamine receptors Ganellin, CR, Shankley, NP, Schwartz, JC, Levi, R, Timmerman, H, Hill, SJ, Haas, HL, Young, JM, Schunack, W	Pharmacol Rev	1997