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NSL1 [cytosol]
Stable Identifier
R-HSA-375309
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
NSL1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96IY1 NSL1
Gene Names
NSL1, C1orf48, DC31, DC8, MIS14
Chain
chain:1-281
Reference Genes
BioGPS Gene:25936 NSL1
COSMIC (genes):NSL1 NSL1
CTD Gene:25936 NSL1
dbSNP Gene:25936 NSL1
ENSEMBL:ENSG00000117697 NSL1
HGNC:24548 NSL1
KEGG:hsa:25936 NSL1
Monarch:25936 NSL1
NCBI Gene:25936 NSL1
OMIM:609174 NSL1
UCSC:Q96IY1 NSL1
Reference Transcript
RefSeq:NM_001042549.1 NSL1
RefSeq:NM_015471.3 NSL1
Other Identifiers
11725639_a_at
11725640_a_at
11728321_a_at
16699112
209484_PM_s_at
209484_s_at
230592_PM_at
230592_at
235799_PM_at
235799_at
2454831
2454833
2454835
2454837
2454839
2454840
2454841
2454842
2454843
2454844
2454845
2454846
2454847
2454848
2454849
2454850
2454851
2454852
2454853
2454854
2454855
2454857
2454862
2454863
2454864
2454865
2454866
2454867
2454870
2454871
25936
41335_at
59425_at
60088_at
71353_r_at
77242_at
7924172
A_24_P370970
A_32_P94976
GE504355
GE56241
GE623521
GO:0000070
GO:0000444
GO:0000775
GO:0000776
GO:0000922
GO:0000940
GO:0005515
GO:0005634
GO:0005694
GO:0005829
GO:0007059
GO:0008608
GO:0016607
GO:0043226
GO:0051301
HMNXSV003019260
HMNXSV003030363
Hs.167002.0.S1_3p_at
Hs.25027.0.A1_3p_at
ILMN_1739210
ILMN_1830362
ILMN_1844862
ILMN_2276820
ILMN_2376160
PH_hs_0002151
PH_hs_0002203
PH_hs_0007361
TC01003810.hg
g9295185_3p_at
Participates
as a component of
Mis12 complex [cytosol] (Homo sapiens)
Inferred To
Nsl1 [cytosol]
(Mus musculus)
Nsl1 [cytosol]
(Rattus norvegicus)
Nsl1/DC31 [cytosol]
(Gallus gallus)
NSL1 [cytosol]
(Bos taurus)
NSL1 [cytosol]
(Canis familiaris)
NSL1 [cytosol]
(Sus scrofa)
nsl1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_056286.3
,
NP_001036014.1
ENSEMBL
ENSP00000486783
,
ENST00000626725
,
ENSP00000355944
,
ENST00000366977
OpenTargets
ENSG00000117697
HPA
ENSG00000117697-NSL1
PRO
Q96IY1
Pharos - Targets
Q96IY1
GlyGen
Q96IY1
PDB
4NF9
,
8Q5H
,
5LSI
,
5LSK
,
5LSJ
,
8PPR
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.8
6
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.643
3
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.643
3
UniProt:P37173 TGFBR2
9
TGFBR2 [plasma membrane]
(R-HSA-170842)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
0.556
3
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