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MIS12 [cytosol]
Stable Identifier
R-HSA-375313
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
Mis12 complex [cytosol] (Homo sapiens)
MIS12 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H081 MIS12
Gene Names
MIS12
Chain
chain:1-205
Reference Genes
BioGPS Gene:79003 MIS12
COSMIC (genes):MIS12 MIS12
CTD Gene:79003 MIS12
dbSNP Gene:79003 MIS12
ENSEMBL:ENSG00000167842 MIS12
ENSEMBL_homo_sapiens_GENE:ENSG00000167842.16 MIS12
HGNC:24967 MIS12
KEGG Gene (Homo sapiens):79003 MIS12
Monarch:79003 MIS12
NCBI Gene:79003 MIS12
OMIM:609178 MIS12
UCSC:Q9H081 MIS12
Reference Transcript
RefSeq:XM_017025035.1 MIS12
RefSeq:NM_001258218.1 MIS12
RefSeq:NM_024039.2 MIS12
RefSeq:XM_017025034.1 MIS12
RefSeq:NM_001258220.1 MIS12
RefSeq:NM_001258217.1 MIS12
RefSeq:XM_017025033.1 MIS12
RefSeq:NM_001258219.1 MIS12
RefSeq:XM_005256797.2 MIS12
Other Identifiers
11725145_a_at
11725146_a_at
11757986_s_at
16830146
221559_PM_s_at
221559_s_at
3707760
3707761
3707764
3707765
3707766
3707767
3707768
53821_at
63378_at
79003
8004144
A_23_P78152
GE82768
GO:0000070
GO:0000278
GO:0000444
GO:0000775
GO:0000776
GO:0000922
GO:0005515
GO:0005634
GO:0005694
GO:0005829
GO:0005856
GO:0007049
GO:0007059
GO:0008608
GO:0043226
GO:0051301
GO:0051315
GO:0051382
GO:0065003
GO:0140014
HMNXSV003036390
ILMN_1718069
PH_hs_0013705
TC17000067.hg
g12652942_3p_a_at
Participates
as a component of
Mis12 complex [cytosol] (Homo sapiens)
Inferred To
MIS12 [cytosol]
(Bos taurus)
MIS12 [cytosol]
(Canis familiaris)
MIS12 [cytosol]
(Sus scrofa)
Ghost homologue of MIS12 [cytosol]
(Gallus gallus)
mis12 [cytosol]
(Xenopus tropicalis)
Mis12 [cytosol]
(Mus musculus)
Mis12 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
XP_016880524.1
,
NP_076944.1
,
NP_001245149.1
,
NP_001245146.1
,
XP_016880523.1
,
NP_001245148.1
,
XP_016880522.1
,
XP_005256854.1
,
NP_001245147.1
OpenTargets
ENSG00000167842
GeneCards
Q9H081
HPA
ENSG00000167842-MIS12
Ensembl
ENSG00000167842
,
ENST00000573759
,
ENST00000381165
,
ENSP00000461252
,
ENST00000611091
,
ENSP00000370557
,
ENSP00000484532
PRO
Q9H081
Pharos - Targets
Q9H081
PDB
5LSK
,
8PPR
,
5LSJ
,
8Q5H
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.643
3
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.643
3
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.643
3
UniProt:O60566 BUB1B
1
BUB1B [cytosol]
(R-HSA-141436)
0.564
2
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