Reactome | NMB(47-56) [extracellular region]

NMB(47-56) [extracellular region]

Stable Identifier

R-HSA-375361

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Neuromedin-B, NMB_HUMAN, NMB

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like peptide [extracellular region] (Homo sapiens)
        
        NMB(47-56) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like peptide [extracellular region] (Homo sapiens)
        
        NMB(47-56) [extracellular region] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like peptide [extracellular region] (Homo sapiens)
        
        NMB(47-56) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like peptide [extracellular region] (Homo sapiens)
        
        NMB(47-56) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like peptide [extracellular region] (Homo sapiens)
        
        NMB(47-56) [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
        
        Bombesin-like peptide [extracellular region] (Homo sapiens)
        
        NMB(47-56) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Bombesin-like receptors bind bombesin homologues (Homo sapiens)
        
        Bombesin-like peptide [extracellular region] (Homo sapiens)
        
        NMB(47-56) [extracellular region] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like peptide [extracellular region] (Homo sapiens)
        
        NMB(47-56) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08949 NMB

Gene Names

NMB

Chain

signal peptide:1-24, peptide:25-56, peptide:47-56, propeptide:60-121

Reference Genes

BioGPS Gene:4828 NMB

COSMIC (genes):NMB NMB

CTD Gene:4828 NMB

dbSNP Gene:4828 NMB

ENSEMBL:ENSG00000197696 NMB

HGNC:7842 NMB

KEGG:hsa:4828 NMB

Monarch:4828 NMB

NCBI Gene:4828 NMB

OMIM:162340 NMB

UCSC:P08949 NMB

Reference Transcript

Participates

as a member of

Bombesin-like peptide [extracellular region] (Homo sapiens)

Inferred To

Nmb [extracellular region] (Mus musculus)

Nmb [extracellular region] (Rattus norvegicus)

nmbb [extracellular region] (Danio rerio)

NMB [extracellular region] (Canis familiaris)

NMB [extracellular region] (Gallus gallus)

NMB [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_066563.2, NP_995580.1

ENSEMBL

ENST00000360476, ENSG00000197696, ENST00000394588, ENSP00000517134, ENSP00000517135, ENSP00000378089, ENSP00000353664, ENST00000708236, ENSG00000291631, ENST00000708237

OpenTargets

ENSG00000197696

GeneCards

NMB

HPA

ENSG00000197696-NMB

PRO

P08949

Pharos - Targets

P08949

GlyGen

P08949

PDB

8H0P, 1C98, 1C9A

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.556	3