C5a receptor binds C5a anaphylatoxin

Stable Identifier
R-HSA-375395
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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C5a receptor binds C5a anaphylatoxin
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C5a (Fernandez HN and Hugli TE, 1978) is a protein fragment released from complement component C5. C5a is a potent anaphylatoxin, causing the release of histamine from mast cells and also being an effective leukocyte attractant. The C5a receptor (complement component 5a receptor 1, C5AR1; Cluster of Differentiation 88, CD88) (Gerard NP and Gerard C, 1991) mediates the pro-inflammatory and chemotactic actions of C5a.
Literature References
PubMed ID Title Journal Year
1847994 The chemotactic receptor for human C5a anaphylatoxin

Gerard, C, Gerard, NP

Nature 1991
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Authored
Jassal, B  (2008-08-21)
Reviewed
Bockaert, J  (2008-09-01)
Created
Jassal, B  (2008-08-26)
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