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SLC7A1 [plasma membrane]
Stable Identifier
R-HSA-375771
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
CAT-1, High affinity cationic amino acid transporter 1
Locations in the PathwayBrowser for interactor UniProt:Q96B77 TMEM186
Expand all
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Amino acid transport across the plasma membrane (Homo sapiens)
SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Homo sapiens)
SLC7A1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30825 SLC7A1
Gene Names
SLC7A1, ATRC1, ERR, REC1L
Chain
chain:1-629
Reference Genes
BioGPS Gene:6541 SLC7A1
COSMIC (genes):SLC7A1 SLC7A1
CTD Gene:6541 SLC7A1
dbSNP Gene:6541 SLC7A1
ENSEMBL:ENSG00000139514 SLC7A1
HGNC:11057 SLC7A1
KEGG:hsa:6541 SLC7A1
Monarch:6541 SLC7A1
NCBI Gene:6541 SLC7A1
OMIM:104615 SLC7A1
UCSC:P30825 SLC7A1
Reference Transcript
RefSeq:XM_005266507.4 SLC7A1
RefSeq:XM_054374878.1 SLC7A1
RefSeq:XM_047430551.1 SLC7A1
RefSeq:XM_054374880.1 SLC7A1
RefSeq:XM_047430552.1 SLC7A1
RefSeq:XM_047430550.1 SLC7A1
RefSeq:XM_054374879.1 SLC7A1
RefSeq:NM_003045.5 SLC7A1
RefSeq:XM_054374877.1 SLC7A1
RefSeq:XM_017020716.1 SLC7A1
Other Identifiers
11722411_a_at
11722412_s_at
11722413_a_at
11722414_at
16777777
206566_PM_at
206566_at
212290_PM_at
212290_at
212292_PM_at
212292_at
212295_PM_s_at
212295_s_at
237858_PM_s_at
237858_s_at
3507709
3507711
3507712
3507713
3507714
3507715
3507718
3507719
3507720
3507721
3507722
3507723
3507724
3507728
3507729
3507730
3507731
3507733
3507734
3507736
3507737
3507740
3507741
3507742
3507743
3507746
3507755
3507757
36274_at
39748_at
49611_at
6541
7970810
A_24_P253251
GE59825
GO:0000064
GO:0001618
GO:0003013
GO:0005215
GO:0005290
GO:0005515
GO:0005886
GO:0006865
GO:0009925
GO:0015171
GO:0015174
GO:0015189
GO:0015807
GO:0015819
GO:0015822
GO:0016020
GO:0016323
GO:0016324
GO:0022857
GO:0032991
GO:0042102
GO:0046718
GO:0055085
GO:0061459
GO:0089718
GO:0097638
GO:0150104
GO:1903352
GO:1903401
GO:1903810
GO:1903826
HMNXSV003032389
HMNXSV003040465
Hs.14846.0.A1_3p_at
Hs.14846.0.A2_3p_at
Hs.14846.0.A3_3p_a_at
Hs.22287.0.A1_3p_at
ILMN_1683859
PH_hs_0031019
TC13000523.hg
X57303_at
g4507046_3p_at
Inferred To
slif [plasma membrane]
(Drosophila melanogaster)
tadr [plasma membrane]
(Drosophila melanogaster)
slc7a1 [plasma membrane]
(Xenopus tropicalis)
ctrC [plasma membrane]
(Dictyostelium discoideum)
Dmel\CG7255 [plasma membrane]
(Drosophila melanogaster)
anon-WO0118547.111 [plasma membrane]
(Drosophila melanogaster)
slc7a1a [plasma membrane]
(Danio rerio)
Slc7a1 [plasma membrane]
(Mus musculus)
Slc7a1 [plasma membrane]
(Rattus norvegicus)
ctrB [plasma membrane]
(Dictyostelium discoideum)
Homologues of SLC7A1 [plasma membrane]
(Dictyostelium discoideum)
Homologues of SLC7A1 [plasma membrane]
(Drosophila melanogaster)
SLC7A1 [plasma membrane]
(Bos taurus)
SLC7A1 [plasma membrane]
(Canis familiaris)
SLC7A1 [plasma membrane]
(Dictyostelium discoideum)
SLC7A1 [plasma membrane]
(Gallus gallus)
SLC7A1 [plasma membrane]
(Sus scrofa)
ctrA [plasma membrane]
(Dictyostelium discoideum)
Cross References
RefSeq
XP_005266564.1
,
XP_047286506.1
,
NP_003036.1
,
XP_016876205.1
,
XP_054230852.1
,
XP_054230855.1
,
XP_054230854.1
,
XP_054230853.1
,
XP_047286508.1
,
XP_047286507.1
Guide to Pharmacology - Targets
891
OpenTargets
ENSG00000139514
ENSEMBL
ENSG00000139514
,
ENST00000380752
,
ENSP00000370128
GeneCards
SLC7A1
HPA
ENSG00000139514-SLC7A1
PRO
P30825
Pharos - Targets
P30825
GlyGen
P30825
HMDB Protein
HMDBP03222
Interactors (102)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BSR8 YIPF4
0.742
5
UniProt:Q12846 STX4
4
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.725
4
UniProt:Q7LGA3 HS2ST1
1
HS2ST1 [Golgi membrane]
(R-HSA-2076393)
0.725
4
UniProt:Q9H9S5 FKRP
1
FKRP [Golgi membrane]
(R-HSA-6785688)
0.725
4
UniProt:Q86Y82 STX12
0.725
4
UniProt:Q969F0 FATE1
0.718
6
UniProt:P21964 COMT
2
COMT [cytosol]
(R-HSA-175974)
COMT [plasma membrane]
(R-HSA-379386)
0.666
4
UniProt:Q13586 STIM1
1
STIM1 [endoplasmic reticulum membrane]
(R-HSA-434675)
0.666
4
UniProt:P25942 CD40
0.666
4
UniProt:Q9NTJ5 SACM1L
2
SACM1L [endoplasmic reticulum membrane]
(R-HSA-1604637)
SACM1L [Golgi membrane]
(R-HSA-1806242)
0.666
4
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.643
3
UniProt:P17152 TMEM11
1
TMEM11 [mitochondrial inner membrane]
(R-HSA-8949578)
0.643
3
UniProt:Q09328 MGAT5
1
MGAT5 [Golgi membrane]
(R-HSA-975896)
0.643
3
UniProt:Q8NC56 LEMD2
1
LEMD2 [nuclear envelope]
(R-HSA-3067329)
0.643
3
UniProt:Q9BXK5 B2L13
0.643
3
UniProt:Q9Y6C9 MTCH2
0.643
3
UniProt:Q9H3K2 GHITM
0.643
3
UniProt:Q96EC8 YIPF6
2
YIPF6 [Golgi membrane]
(R-HSA-434346)
YIPF6 [cytoplasmic vesicle membrane]
(R-HSA-434199)
0.643
3
UniProt:O43760 SNG2
0.643
3
UniProt:Q96B77 TMEM186
1
TMEM186 [mitochondrial inner membrane]
(R-HSA-9708009)
0.643
3
UniProt:Q8N6M3 FITM2
1
FITM2 [endoplasmic reticulum membrane]
(R-HSA-8857678)
0.643
3
UniProt:Q9UHQ9 CYB5R1
3
CYB5R1 [plasma membrane]
(R-HSA-8848888)
CYB5R1 [platelet alpha granule membrane]
(R-HSA-8848891)
CYB5R1 [endoplasmic reticulum membrane]
(R-HSA-6806847)
0.643
3
UniProt:Q9NRZ5 AGPAT4
1
AGPAT4 [endoplasmic reticulum membrane]
(R-HSA-61809)
0.643
3
UniProt:O95858 TSPAN15
2
TSPAN15 [plasma membrane]
(R-HSA-9010043)
TSPAN15 [endoplasmic reticulum lumen]
(R-HSA-9010117)
0.643
4
UniProt:Q9BX95 SGPP1
1
SGPP1 [endoplasmic reticulum membrane]
(R-HSA-428673)
0.643
3
UniProt:Q8WUY8 NAT14
0.643
3
UniProt:P11912 CD79A
2
p-Y188,Y199-CD79A [plasma membrane]
(R-HSA-983539)
CD79A [plasma membrane]
(R-HSA-197154)
0.556
3
UniProt:Q9NRQ5 SMCO4
0.556
3
UniProt:Q5J8X5 M4A13
0.556
3
UniProt:Q8N138 ORMDL3
4
ORMDL3 [endoplasmic reticulum membrane]
(R-HSA-8865589)
ORMDL3 [specific granule membrane]
(R-HSA-6799643)
ORMDL3 [plasma membrane]
(R-HSA-6806293)
ORMDL3 [secretory granule membrane]
(R-HSA-6800882)
0.556
3
UniProt:O14735 CDIPT
1
CDIPT [endoplasmic reticulum membrane]
(R-HSA-1498749)
0.556
3
IntAct:EBI-22589183 CCSB ORF ID
0.556
3
UniProt:Q8TAZ6 CKLF2
0.556
3
IntAct:EBI-23641393 CCSB ORF ID
0.556
3
UniProt:P55061 BI1
0.556
3
IntAct:EBI-23624354 CCSB ORF ID
0.556
3
UniProt:Q9NY72 SCN3B
1
SCN3B [plasma membrane]
(R-HSA-197921)
0.556
3
UniProt:Q96D05-2 FAM241B
0.556
3
UniProt:O95214 LERL1
0.556
3
UniProt:Q9NUM3 S39A9
0.556
3
UniProt:Q8NHW4 CCL4L1
1
CCL4L1 [extracellular region]
(R-HSA-8865389)
0.556
3
UniProt:Q9Y6G1 TM14A
0.556
3
UniProt:Q9GZY8-5 MFF
0.556
3
UniProt:O15243 OBRG
0.556
3
UniProt:Q9HA82 CERS4
1
CERS4 [endoplasmic reticulum membrane]
(R-HSA-428138)
0.556
3
UniProt:Q9BSE4 HERP2
0.556
3
UniProt:Q13520 AQP6
1
AQP6 [transport vesicle membrane]
(R-HSA-431741)
0.556
3
UniProt:O60242 AGRB3
0.556
3
UniProt:Q8N3T1 GALNT15
1
GALNT15 [Golgi membrane]
(R-HSA-913705)
0.556
3
UniProt:Q96HH6 TMM19
0.556
3
UniProt:O00258 GET1
1
WRB [endoplasmic reticulum membrane]
(R-HSA-9609521)
0.556
3
UniProt:Q9BV81 EMC6
0.556
3
UniProt:Q8TDT2 GP152
0.556
3
UniProt:P54315 PNLIPRP1
1
PNLIPRP1 [extracellular region]
(R-HSA-3902876)
0.556
3
UniProt:Q5TGU0 TSPO2
0.556
3
UniProt:Q9NWF4 SLC52A1
1
SLC52A1 [plasma membrane]
(R-HSA-5216118)
0.556
3
UniProt:A5PKU2 A5PKU2
0.556
3
UniProt:P16278 GLB1
8
GLB1 [lysosomal lumen]
(R-HSA-1605623)
GLB1 [ficolin-1-rich granule lumen]
(R-HSA-6800968)
GLB1 [extracellular region]
(R-HSA-6806213)
GLB1 [azurophil granule lumen]
(R-HSA-6799124)
GLB1 W273L [lysosomal lumen]
(R-HSA-2262738)
GLB1 R482C [lysosomal lumen]
(R-HSA-2262739)
GLB1 Y83C [lysosomal lumen]
(R-HSA-2262735)
GLB1 W509C [lysosomal lumen]
(R-HSA-2262732)
0.556
3
UniProt:O14880 MGST3
1
MGST3 [endoplasmic reticulum membrane]
(R-HSA-176053)
0.556
3
UniProt:Q9NP94 SLC39A2
1
SLC39A2 [plasma membrane]
(R-HSA-442395)
0.556
3
UniProt:P13236 CCL4
1
CCL4(24-92) [extracellular region]
(R-HSA-443976)
0.556
3
UniProt:Q9BQ51 PDCD1LG2
1
PDCD1LG2 [plasma membrane]
(R-HSA-3211774)
0.556
3
UniProt:Q96JF0-2 ST6GAL2
0.556
3
UniProt:Q96Q45-2 TMEM237
0.556
3
UniProt:P43378 PTPN9
1
PTPN9 [nucleoplasm]
(R-HSA-9008907)
0.556
3
UniProt:P07357 C8A
1
C8A [extracellular region]
(R-HSA-173716)
0.556
3
UniProt:Q05940 SLC18A2
2
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane]
(R-HSA-372544)
SLC18A2 [plasma membrane]
(R-HSA-374907)
0.556
3
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
5
UniProt:P27352 CBLIF
3
CBLIF S27Cfs*23 [extracellular region]
(R-HSA-3315461)
CBLIF [extracellular region]
(R-HSA-2980918)
CBLIF [lysosomal lumen]
(R-HSA-3000272)
0.556
3
UniProt:Q15436 SEC23A
4
SEC23A [endoplasmic reticulum membrane]
(R-HSA-203976)
SEC23A [cytosol]
(R-HSA-203972)
SEC23A [ER to Golgi transport vesicle membrane]
(R-HSA-204024)
p-S738,T744 SEC23A [cytosol]
(R-HSA-5685740)
0.556
3
UniProt:P27449 ATP6V0C
7
ATP6V0C [endosome membrane]
(R-HSA-912591)
ATP6V0C [azurophil granule membrane]
(R-HSA-6799363)
ATP6V0C [plasma membrane]
(R-HSA-6806254)
ATP6V0C [tertiary granule membrane]
(R-HSA-6800991)
ATP6V0C [ficolin-1-rich granule membrane]
(R-HSA-6800908)
ATP6V0C [phagocytic vesicle membrane]
(R-HSA-1222603)
ATP6V0C [lysosomal membrane]
(R-HSA-9640194)
0.556
3
UniProt:Q3KNW5 SLC10A6
1
SLC10A6 [plasma membrane]
(R-HSA-433091)
0.556
3
UniProt:P02652 APOA2
6
APOA2(24-100) [cytosol]
(R-HSA-2395772)
APOA2(24-100) [early endosome]
(R-HSA-2569092)
APOA2(24-100) [endoplasmic reticulum lumen]
(R-HSA-174689)
APOA2(24-100) [extracellular region]
(R-HSA-174775)
p-APOA2 [endoplasmic reticulum lumen]
(R-HSA-8957014)
APOA2 [endoplasmic reticulum lumen]
(R-HSA-8956780)
0.556
3
UniProt:P50876 RNF144A
1
RNF144A [endosome membrane]
(R-HSA-8938771)
0.556
3
UniProt:Q9BRI3 SLC30A2
2
SLC30A2 [endosome membrane]
(R-HSA-435363)
SLC30A2 [synaptic vesicle membrane]
(R-HSA-4084714)
0.556
3
UniProt:P60763 RAC3
3
RAC3 [endoplasmic reticulum membrane]
(R-HSA-9714693)
RAC3 [plasma membrane]
(R-HSA-195338)
RAC3 [cytosol]
(R-HSA-195335)
0.527
2
UniProt:B7ZAQ6 GPHRA
0.527
2
UniProt:P11117 PPAL
0.527
2
UniProt:Q9Y5Y0 FLVCR1
0.527
2
UniProt:O75907 DGAT1
3
DGAT1 [plasma membrane]
(R-HSA-6806313)
DGAT1 [specific granule membrane]
(R-HSA-6799564)
DGAT1 [endoplasmic reticulum membrane]
(R-HSA-53579)
0.527
2
UniProt:Q9H8H3 TMT1A
2
METTL7A [extracellular region]
(R-HSA-6800468)
METTL7A [tertiary granule lumen]
(R-HSA-6800170)
0.527
2
UniProt:Q8IYS2 K2013
0.527
2
UniProt:O60779 SLC19A2
1
SLC19A2 [plasma membrane]
(R-HSA-199636)
0.527
2
UniProt:Q5VW38 GP107
0.527
2
UniProt:P52569 SLC7A2
0.527
3
UniProt:Q5HYI8 RABL3
0.527
2
UniProt:Q6ZMG9 CERS6
1
CERS6 [endoplasmic reticulum membrane]
(R-HSA-428145)
0.527
2
UniProt:Q9Y397 ZDHHC9
1
ZDHHC9 [Golgi membrane]
(R-HSA-9647931)
0.527
2
UniProt:Q07065 CKAP4
7
CKAP4 [endoplasmic reticulum lumen]
(R-HSA-8956737)
p-CKAP4 [endoplasmic reticulum lumen]
(R-HSA-8956926)
CKAP4 [specific granule membrane]
(R-HSA-6799552)
CKAP4 [plasma membrane]
(R-HSA-5686306)
CKAP4 [azurophil granule membrane]
(R-HSA-6799559)
PALM-C100-CKAP4 [plasma membrane]
(R-HSA-5686280)
PALM-C100-CKAP4 [lamellar body]
(R-HSA-5686285)
0.527
2
UniProt:Q8NBJ4 GOLM1
2
p-GOLM1 [endoplasmic reticulum lumen]
(R-HSA-8956938)
GOLM1 [endoplasmic reticulum lumen]
(R-HSA-8956710)
0.527
2
UniProt:Q9GZR5 ELOVL4
1
ELOVL4 [endoplasmic reticulum membrane]
(R-HSA-548705)
0.527
2
UniProt:A0PK00 T120B
0.527
2
UniProt:Q2TAA5 ALG11
6
ALG11 Y279S [endoplasmic reticulum membrane]
(R-HSA-4570575)
ALG11 E398K [endoplasmic reticulum membrane]
(R-HSA-4570576)
ALG11 Q318P [endoplasmic reticulum membrane]
(R-HSA-4570582)
ALG11 L86S [endoplasmic reticulum membrane]
(R-HSA-4570580)
ALG11 L381S [endoplasmic reticulum membrane]
(R-HSA-4570581)
ALG11 [endoplasmic reticulum membrane]
(R-HSA-449267)
0.527
2
UniProt:Q9NRZ7 AGPAT3
2
AGPAT3 [endoplasmic reticulum membrane]
(R-HSA-61807)
AGPAT3 [Golgi membrane]
(R-HSA-8849239)
0.527
2
UniProt:A0PJW6 TMEM223
1
TMEM223 [mitochondrial inner membrane]
(R-HSA-9865797)
0.527
2
UniProt:P17931 LGALS3
3
LGALS3 [plasma membrane]
(R-HSA-879445)
LGALS3 [secretory granule membrane]
(R-HSA-6803327)
LGALS3 [ficolin-1-rich granule membrane]
(R-HSA-6803307)
0.527
2
UniProt:P26842 CD27
1
CD27 [plasma membrane]
(R-HSA-5666994)
0.527
2
UniProt:Q7Z7B1 PIGW
1
PIGW [endoplasmic reticulum membrane]
(R-HSA-162693)
0.527
2
UniProt:Q9NYP7 ELOVL5
1
ELOVL5 [endoplasmic reticulum membrane]
(R-HSA-548679)
0.527
2
UniProt:O00186 STXBP3
4
p-Y521-STXBP3 [plasma membrane]
(R-HSA-2263472)
STXBP3 [plasma membrane]
(R-HSA-2263473)
p-STXBP3 [cytosol]
(R-HSA-114680)
STXBP3 [cytosol]
(R-HSA-114682)
0.527
2
UniProt:O15228 GNPAT
3
GNPAT [cytosol]
(R-HSA-9033129)
GNPAT [peroxisomal membrane]
(R-HSA-1500605)
GNPAT [peroxisomal matrix]
(R-HSA-53413)
0.527
2
UniProt:Q92685 ALG3
5
ALG3 [endoplasmic reticulum membrane]
(R-HSA-449287)
ALG3 W71R [endoplasmic reticulum membrane]
(R-HSA-4720466)
ALG3 G118D [endoplasmic reticulum membrane]
(R-HSA-4720468)
ALG3 M157K [endoplasmic reticulum membrane]
(R-HSA-4720484)
ALG3 R171Q [endoplasmic reticulum membrane]
(R-HSA-4720470)
0.527
2
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