Reactome | ABL1 [cytosol]

ABL1 [cytosol]

Stable Identifier

R-HSA-375987

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proto-oncogene tyrosine-protein kinase ABL1, ABL1_HUMAN

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Parasite infection (Homo sapiens)
        
        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        ABL phosphorylates WAVEs (Homo sapiens)
        
        ABL1 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
        
        ABL phosphorylates WAVEs (Homo sapiens)
        
        ABL1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P00519 ABL1

Gene Names

ABL1, ABL, JTK7

Chain

chain:1-1130

Reference Genes

COSMIC (genes):ABL1 ABL1

dbSNP Gene:25 ABL1

ENSEMBL:ENSG00000097007 ABL1

Participates

as a component of

as an input of

as a member of

ABL [cytosol] (Homo sapiens)

Other forms of this molecule

p-S456-ABL1 [nucleoplasm]

ABL1 [nucleoplasm]

p-Y226,Y393-ABL1 [cytosol]

p-Y226,Y393-ABL1 [nucleoplasm]

p-Y393-ABL1 [cytosol]

Inferred To

ABL1 [cytosol] (Bos taurus)

ABL1 [cytosol] (Caenorhabditis elegans)

ABL1 [cytosol] (Canis familiaris)

ABL1 [cytosol] (Drosophila melanogaster)

ABL1 [cytosol] (Gallus gallus)

ABL1 [cytosol] (Mus musculus)

ABL1 [cytosol] (Rattus norvegicus)

ABL1 [cytosol] (Sus scrofa)

ABL1 [cytosol] (Xenopus tropicalis)

Interactors (43)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IZP0 ABI1	2	p-5S-ABI1 [cytosol] (R-HSA-2029034) ABI1 [cytosol] (R-HSA-1671643)	0.9	11
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.889	8
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.827	6
UniProt:O43196 MSH5	1	MSH5 [nucleoplasm] (R-HSA-912435)	0.819	10
UniProt:Q13671 RIN1	1	RIN1 [cytosol] (R-HSA-8875287)	0.786	6
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.763	6
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.744	5
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.743	4
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.725	4
IntAct:EBI-7094147 P41			0.713	5
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.708	4
UniProt:Q13315 ATM	5	ATM [cytosol] (R-HSA-9665171) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043)	0.704	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.692	3
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.667	5
UniProt:Q13905 RAPGEF1	2	RAPGEF1 [cytosol] (R-HSA-913472) RAPGEF1 [endosome] (R-HSA-3008667)	0.656	4
UniProt:Q03468 ERCC6	2	Ub-ERCC6 [nucleoplasm] (R-HSA-6781853) ERCC6 [nucleoplasm] (R-HSA-54429)	0.655	8
UniProt:P15941-12 MUC1			0.645	4
UniProt:Q9NYB9 ABI2	2	p-4S-ABI2 [cytosol] (R-HSA-2029003) ABI2 [cytosol] (R-HSA-1671647)	0.641	3
IntAct:EBI-3946155 ABL-TIDE			0.609	5
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.602	3
UniProt:P15498 VAV1	5	VAV1 [plasma membrane] (R-HSA-1045153) VAV1 [cytosol] (R-HSA-195066) p-Y174-VAV1 [cytosol] (R-HSA-437946) p-Y142,Y160,Y174-VAV1 [plasma membrane] (R-HSA-389323) p-Y-VAV1 [cytosol] (R-HSA-9029087)	0.602	5
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.602	7
UniProt:Q9Y4G6 TLN2			0.602	3
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.591	6
UniProt:Q38SD2 LRRK1			0.59	3
UniProt:Q9Y6W5 WASF2	3	p-Y150,S343,T346-WASF2 [cytosol] (R-HSA-2130179) p-Y150-WASF2 [cytosol] (R-HSA-2130193) WASF2 [cytosol] (R-HSA-200972)	0.59	2
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.589	2
UniProt:O35158	1	Cdon [plasma membrane] (R-RNO-197892)	0.581	4
UniProt:Q92918 M4K1			0.573	3
UniProt:Q92558 WASF1	3	WASF1 [cytosol] (R-HSA-200965) p-Y151-WASF1 [cytosol] (R-HSA-2029058) p-Y151,S,T-WASF1 [cytosol] (R-HSA-5672390)	0.571	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.558	2
UniProt:P51692 STAT5B	4	p-STAT5B [cytosol] (R-HSA-8983127) p-Y699-STAT5B [nucleoplasm] (R-HSA-508016) p-Y699-STAT5B [cytosol] (R-HSA-507939) STAT5B [cytosol] (R-HSA-380737)	0.558	2
UniProt:O14672 ADAM10	6	ADAM10(215-824) [plasma membrane] (R-HSA-179885) ADAM10 [plasma membrane] (R-HSA-157237) ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956768) p-ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956999) ADAM10 [specific granule membrane] (R-HSA-6799566) ADAM10 [tertiary granule membrane] (R-HSA-6800992)	0.544	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.544	2
UniProt:O60504-2 SORBS3			0.544	5
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.536	2
UniProt:P05107 ITGB2	4	ITGB2 [plasma membrane] (R-HSA-198010) ITGB2 [ficolin-1-rich granule membrane] (R-HSA-6803310) ITGB2 [specific granule membrane] (R-HSA-6803284) ITGB2 [tertiary granule membrane] (R-HSA-6803342)	0.524	4
UniProt:Q4KMG0 CDON	1	CDON [plasma membrane] (R-HSA-197892)	0.524	2
UniProt:Q9BX66 SORBS1	1	SORBS1 [cytosol] (R-HSA-445795)	0.524	2
UniProt:Q15464 SHB	2	pS-SHB [cytosol] (R-HSA-5228991) SHB [cytosol] (R-HSA-4420213)	0.524	5
IntAct:EBI-7319639 P41R			0.508	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.483	2
UniProt:P15941 MUC1	19	MUC1(24-1255) [plasma membrane] (R-HSA-6793976) Core 8 (MUC1) [Golgi lumen] (R-HSA-1462219) Core 2S (MUC1) [Golgi lumen] (R-HSA-6786333) Core 5 (MUC1) [Golgi lumen] (R-HSA-1462231) Core 4 (MUC1) [Golgi lumen] (R-HSA-1462154) Core 3 (MUC1) [Golgi lumen] (R-HSA-1462068) Core 7 (MUC1) [Golgi lumen] (R-HSA-1462105) extended Core 6 (MUC1) [Golgi lumen] (R-HSA-1967019) Core 6 (MUC1) [Golgi lumen] (R-HSA-1462085) MUC1(24-1255) [Golgi lumen] (R-HSA-913611) Disialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463518) Sialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463531) Sialyl-2,3 T-antigen (MUC1) [Golgi lumen] (R-HSA-1463483) T-antigen (MUC1) [Golgi lumen] (R-HSA-1462359) Sialyl Tn antigen (MUC1) [Golgi lumen] (R-HSA-1463526) GalNAc-MUC1(24-1255) [Golgi lumen] (R-HSA-913642) Core 2a (MUC1) [Golgi lumen] (R-HSA-6784286) Core 2 (MUC1) [Golgi lumen] (R-HSA-1462167) GalNAc-MUC1(24-1255) [plasma membrane] (R-HSA-8858449)	0.463	4

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