Reactome | ABL2 [cytosol]

ABL2 [cytosol]

Stable Identifier

R-HSA-375998

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein kinase ABL2, ABL2_HUMAN

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Locations in the PathwayBrowser for interactor ChEBI:49375 DASATINIB

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External Reference Information

External Reference

UniProt:P42684 ABL2

Gene Names

ABL2, ABLL, ARG

Chain

initiator methionine:, chain:2-1182

Reference Genes

BioGPS Gene:27 ABL2

COSMIC (genes):ABL2 ABL2

CTD Gene:27 ABL2

dbSNP Gene:27 ABL2

ENSEMBL:ENSG00000143322 ABL2

HGNC:77 ABL2

KEGG:hsa:27 ABL2

Monarch:27 ABL2

NCBI Gene:27 ABL2

OMIM:164690 ABL2

UCSC:P42684 ABL2

Reference Transcript

Participates

as a candidate of

as a component of

active FLT3:ABL2 [plasma membrane] (Homo sapiens)

as an input of

Active FLT3 binds to ABL2 (Homo sapiens)

as a member of

ABL [cytosol] (Homo sapiens)

Inferred To

Abl2 [cytosol] (Mus musculus)

Abl2 [cytosol] (Rattus norvegicus)

abl-1 [cytosol] (Caenorhabditis elegans)

Abl [cytosol] (Drosophila melanogaster)

abl2 [cytosol] (Xenopus tropicalis)

ABL2 [cytosol] (Bos taurus)

ABL2 [cytosol] (Canis familiaris)

ABL2 [cytosol] (Gallus gallus)

ABL2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001161711.1, XP_005245145.1, NP_001161710.1, NP_001129473.1, NP_001129472.1, NP_005149.4, NP_001161708.1, NP_001161709.1, NP_009298.1

ZINC - World Drugs

ABL2_HUMAN

Guide to Pharmacology - Targets

1924

OpenTargets

ENSG00000143322

ENSEMBL

ENST00000367623, ENSP00000423578, ENST00000507173, ENST00000511413, ENSP00000423413, ENSP00000426831, ENSP00000427562, ENSP00000424697, ENSP00000356595, ENSG00000143322, ENSP00000339209, ENST00000512653, ENST00000344730, ENST00000502732, ENST00000504405

ZINC - FDA approved

ABL2_HUMAN

ZINC - Substances

ABL2_HUMAN

ZINC - Biogenic

ABL2_HUMAN

ZINC target

P42684

PRO

P42684

GlyGen

P42684

PDB

2ECD, 2KK1, 5NP3, 2XYN, 3GVU, 5NP5, 3HMI, 3ULR, 4EIH

ZINC - Investigational

ABL2_HUMAN

IntEnz

2.7.10.2

HPA

ENSG00000143322-ABL2

GeneCards

ABL2

Pharos - Targets

P42684

ZINC - Predictions - Purchasable

ABL2_HUMAN

HMDB Protein

HMDBP01329

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13671 RIN1	1	RIN1 [cytosol] (R-HSA-8875287)	0.803	7
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.77	6
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.731	6
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [nucleoplasm] (R-HSA-5082380) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.725	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.692	9
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.643	3
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.602	4
UniProt:P36888 FLT3	20	FLT3 F691I [plasma membrane] (R-HSA-9702900) FLT3 N676D [plasma membrane] (R-HSA-9702895) FLT3 R834Q [plasma membrane] (R-HSA-9691899) FLT3 Y572C [plasma membrane] (R-HSA-9691902) FLT3 A848P [plasma membrane] (R-HSA-9702909) FLT3 A627P [plasma membrane] (R-HSA-9699448) FLT3 F621L [plasma membrane] (R-HSA-9699426) p-Y768,Y969 FLT3 [plasma membrane] (R-HSA-9698405) Ub-pY FLT3 [endosome membrane] (R-HSA-9706174) Ub-pY FLT3 [plasma membrane] (R-HSA-9706171) FLT3 V592G [plasma membrane] (R-HSA-9691071) FLT3 F590_F605dup [plasma membrane] (R-HSA-9697939) FLT3 F590G Y591D [plasma membrane] (R-HSA-9691062) FLT3 F594L [plasma membrane] (R-HSA-9691058) FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane] (R-HSA-9699433) FLT3 V579A [plasma membrane] (R-HSA-9691051) FLT3 Y599_D600insGLYVDFREYEY [plasma membrane] (R-HSA-9696044) FLT3 Y591_V592insVDFREDREHH [plasma membrane] (R-HSA-9696043) FLT3 D600_L601insMGMGGECNPGRQ [plasma membrane] (R-HSA-9690076) FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane] (R-HSA-9696033)	0.544	3
UniProt:Q9UL15 BAG5	1	BAG5 [cytosol] (R-HSA-5255453)	0.527	2
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.527	2
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.527	2
UniProt:O60504 SORBS3	1	SORBS3 [cytosol] (R-HSA-445805)	0.527	2
ChEBI:49375 DASATINIB			0.499	2
ChEBI:45783 IMATINIB			0.499	2
ChEBI:39112 BOSUTINIB			0.499	2
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) proHRAS [cytosol] (R-HSA-9647765) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) HRAS [plasma membrane] (R-HSA-62717) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.462	2