DSCAM interactions

Stable Identifier
Homo sapiens
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DSCAM (Down syndrome cell adhesion molecule) is one of the members of the Ig superfamily CAMs with a domain architecture comprising 10 Ig domains, 6 fibronectin type III (FN) repeats, a single transmembrane and a C terminal cytoplasmic domain. DSCAM is implicated in Down syndrome (DS) due to the chromosomal location of the DSCAM gene, but no evidence supports a direct involvement of DSCAM with DS. It likely functions as a cell surface receptor mediating axon pathfinding. Besides these important implications, little is known about the physiological function or the molecular mechanism of DSCAM signal transduction in mammalian systems. A closely related DSCAM paralogue Down syndrome cell adhesion moleculelike protein 1 (DSCAML1) is present in humans. Both these proteins are involved in homophilic intercellular interactions.

Literature References
PubMed ID Title Journal Year
10925149 Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion

Agarwala, KL, Nakamura, S, Tsutsumi, Y, Yamakawa, K

Brain Res Mol Brain Res 2000
18585357 DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1

Ly, A, Nikolaev, A, Suresh, G, Zheng, Y, Tessier-Lavigne, M, Stein, E

Cell 2008
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