Reactome | CLASP1 [cytosol]

CLASP1 [cytosol]

Stable Identifier

R-HSA-376230

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Clasp1

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Role of ABL in ROBO-SLIT signaling (Homo sapiens)
        
        Activation of CLASP (Homo sapiens)
        
        CLASP [cytosol] (Homo sapiens)
        
        CLASP1 [cytosol] (Homo sapiens)
        
        SLIT2:ROBO1:ABL:CLASP [plasma membrane] (Homo sapiens)
        
        CLASP [cytosol] (Homo sapiens)
        
        CLASP1 [cytosol] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CLASP1 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CLASP1 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        CLASP1 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CLASP1 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CLASP1 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CLASP1 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CLASP1 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CLASP1 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CLASP1 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CLASP1 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CLASP1 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CLASP1 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CLASP1 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CLASP1 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CLASP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q7Z460 CLASP1

Gene Names

CLASP1, KIAA0622, MAST1

Chain

chain:1-1538

Reference Genes

BioGPS Gene:23332 CLASP1

COSMIC (genes):CLASP1 CLASP1

COSMIC (genes):MAST1 CLASP1

CTD Gene:23332 CLASP1

dbSNP Gene:23332 CLASP1

ENSEMBL:ENSG00000074054 CLASP1

HGNC:17088 CLASP1

KEGG:hsa:23332 CLASP1

Monarch:23332 CLASP1

NCBI Gene:23332 CLASP1

OMIM:605852 CLASP1

UCSC:Q7Z460 CLASP1

Reference Transcript

Other Identifiers

11726755_s_at

11735029_a_at

11735030_a_at

16902296

212752_PM_at

212752_at

23332

2573638

2573640

2573642

2573643

2573644

2573645

2573646

2573647

2573648

2573649

2573653

2573654

2573657

2573658

2573659

2573660

2573662

2573663

2573664

2573665

2573673

2573674

2573677

2573679

2573680

2573681

2573683

2573684

2573686

2573687

2573688

2573690

2573691

2573692

2573693

2573694

2573697

2573698

2573699

2573700

2573702

2573703

2573704

2573713

2573714

2573715

2573721

2573722

2573723

2573724

2573727

2573728

2573729

2573730

2573731

2573732

2573734

2573740

2573742

2573746

2573747

2573750

2573751

2573753

2573754

2573755

2573768

2573769

2573770

2573771

2573775

39838_at

8054888

A_23_P311232

A_33_P3312975

GE53338

GO:0000226

GO:0000775

GO:0000776

GO:0001578

GO:0002162

GO:0005515

GO:0005694

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005819

GO:0005828

GO:0005829

GO:0005856

GO:0005874

GO:0005876

GO:0005881

GO:0005925

GO:0005938

GO:0006903

GO:0007010

GO:0007020

GO:0007026

GO:0007030

GO:0007052

GO:0007163

GO:0008017

GO:0008092

GO:0010458

GO:0010470

GO:0010634

GO:0010717

GO:0015630

GO:0015631

GO:0016020

GO:0030953

GO:0030981

GO:0031023

GO:0031110

GO:0031111

GO:0031116

GO:0031592

GO:0034453

GO:0035371

GO:0040001

GO:0043226

GO:0043515

GO:0045180

GO:0045921

GO:0051010

GO:0051294

GO:0051301

GO:0051494

GO:0051497

GO:0051893

GO:0070507

GO:0072686

GO:0090091

GO:0090162

GO:0090307

GO:1902904

GO:1903690

GO:1904261

HMNXSV003030975

Hs.11238.0.S1_3p_at

ILMN_1700507

PH_hs_0025548

TC02002264.hg

TC02004543.hg

TC02004544.hg

Participates

as a component of

as a member of

CLASP [cytosol] (Homo sapiens)

Inferred To

CLASP1 [cytosol] (Bos taurus)

CLASP1 [cytosol] (Canis familiaris)

CLASP1 [cytosol] (Gallus gallus)

CLASP1 [cytosol] (Sus scrofa)

Clasp1 [cytosol] (Mus musculus)

Clasp1 [cytosol] (Rattus norvegicus)

clasp1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_056097.1, NP_001193980.1, NP_001135745.1, XP_011509150.1, NP_001135746.1

ENSEMBL

ENST00000409078, ENST00000541377, ENSP00000263710, ENSP00000441625, ENST00000263710, ENSP00000386442

OpenTargets

ENSG00000074054

HPA

ENSG00000074054-CLASP1

PRO

Q7Z460

Pharos - Targets

Q7Z460

GlyGen

Q7Z460

PDB

6MQ7, 4K92, 6MQ5

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.745	7
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.706	4
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.649	7
UniProt:Q9HC77 CENPJ	2	CENPJ [cytosol] (R-HSA-380291) p-S589,S595-CENPJ [cytosol] (R-HSA-6801670)	0.615	3
UniProt:Q9JK25	1	Clip1 [cytosol] (R-RNO-377732)	0.508	2
UniProt:Q14203 DCTN1	7	DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711969) DCTN1(1-599)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711960) DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol] (R-HSA-9701997) DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711959) DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711953) DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711962) DCTN1 [cytosol] (R-HSA-535580)	0.483	3
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.471	3

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