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AHCTF1 [cytosol]
Stable Identifier
R-HSA-376244
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MEL-28, ELYS, Embryonic large molecule derived from yolk sac
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Postmitotic nuclear pore complex (NPC) reformation (Homo sapiens)
AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Nup107-160 complex:AHCTF1:Chromatin [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
NUP93 recruits the Nup62 complex (Homo sapiens)
Nup62 complex:Nup93 complex:NUP188:NDC1:POM121:AHCTF1:Chromatin [nuclear envelope] (Homo sapiens)
Nup93 complex:NUP188:NDC1:POM121:AHCTF1:Chromatin [nuclear envelope] (Homo sapiens)
POM121:Nup107-160 complex:AHCTF1:Chromatin [nuclear envelope] (Homo sapiens)
Nup107-160 complex:AHCTF1:Chromatin [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Nup93 complex:NUP188:NDC1:POM121:AHCTF1:Chromatin [nuclear envelope] (Homo sapiens)
POM121:Nup107-160 complex:AHCTF1:Chromatin [nuclear envelope] (Homo sapiens)
Nup107-160 complex:AHCTF1:Chromatin [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
POM121 and NDC1 bind the Nup93 complex (Homo sapiens)
Nup93 complex:NUP188:NDC1:POM121:AHCTF1:Chromatin [nuclear envelope] (Homo sapiens)
POM121:Nup107-160 complex:AHCTF1:Chromatin [nuclear envelope] (Homo sapiens)
Nup107-160 complex:AHCTF1:Chromatin [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
POM121:Nup107-160 complex:AHCTF1:Chromatin [nuclear envelope] (Homo sapiens)
Nup107-160 complex:AHCTF1:Chromatin [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
POM121 binds the Nup107-Nup160 complex (Homo sapiens)
Nup107-160 complex:AHCTF1:Chromatin [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
POM121:Nup107-160 complex:AHCTF1:Chromatin [nuclear envelope] (Homo sapiens)
Nup107-160 complex:AHCTF1:Chromatin [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
AHCTF1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WYP5 AHCTF1
Gene Names
AHCTF1, ELYS, TMBS62, MSTP108
Chain
chain:1-2266
Reference Genes
BioGPS Gene:25909 AHCTF1
COSMIC (genes):AHCTF1 AHCTF1
CTD Gene:25909 AHCTF1
dbSNP Gene:25909 AHCTF1
ENSEMBL:ENSG00000153207 AHCTF1
HGNC:24618 AHCTF1
KEGG:hsa:25909 AHCTF1
Monarch:25909 AHCTF1
NCBI Gene:25909 AHCTF1
OMIM:610853 AHCTF1
UCSC:Q8WYP5 AHCTF1
Reference Transcript
RefSeq:NM_015446.4 AHCTF1
RefSeq:XM_006711758.1 AHCTF1
RefSeq:NM_001323342.1 AHCTF1
Other Identifiers
11730252_s_at
11730253_a_at
1560224_PM_at
1560224_at
16701440
214766_PM_s_at
214766_s_at
226115_PM_at
226115_at
2465325
2465326
2465327
2465328
2465329
2465330
2465331
2465334
2465335
2465336
2465337
2465338
2465340
2465342
2465344
2465345
2465346
2465347
2465348
2465349
2465350
2465351
2465356
2465357
2465358
2465360
2465361
2465362
2465363
2465364
2465366
2465367
2465368
2465369
2465370
2465371
2465372
2465373
2465374
2465375
2465376
2465377
2465378
2465379
2465381
2465383
2465384
2465385
2465387
2465388
2465389
2465390
2465391
2465392
2465394
2583929
2583931
2583933
2583934
2583935
2583936
2583937
2583943
2583945
2583947
2583949
2583951
2583955
2583956
2583957
2583958
2583959
2583960
2583961
2583962
2583963
2583965
2583967
2583969
2583971
2583973
2583975
2583977
2583979
2583981
2583983
2583985
2583987
2583989
25909
35672_at
61864_at
7925622
8056220
A_23_P63584
A_24_P28657
A_32_P157228
A_33_P3666346
GE56349
GO:0000775
GO:0000776
GO:0000785
GO:0003677
GO:0005634
GO:0005635
GO:0005643
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006913
GO:0015031
GO:0016363
GO:0016604
GO:0031080
GO:0031965
GO:0032465
GO:0043226
GO:0051028
GO:0051292
GO:0051301
GO:0065003
GO:0070062
HMNXSV003018144
Hs.33363.0.A2_3p_at
Hs.33363.1.S1_3p_a_at
Hs2.433190.1.S1_3p_at
ILMN_1666679
ILMN_1747504
ILMN_1809139
PH_hs_0028849
PH_hs_0038407
TC01004062.hg
TC02002477.hg
Participates
as a component of
Nup107-160 complex:AHCTF1:Chromatin [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
as an input of
AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Homo sapiens)
Inferred To
AHCTF1 [cytosol]
(Bos taurus)
AHCTF1 [cytosol]
(Canis familiaris)
AHCTF1 [cytosol]
(Gallus gallus)
AHCTF1 [cytosol]
(Sus scrofa)
Ahctf1 [cytosol]
(Mus musculus)
Ahctf1 [cytosol]
(Rattus norvegicus)
Elys [cytosol]
(Drosophila melanogaster)
ahctf1 [cytosol]
(Xenopus tropicalis)
Ghost homologue of AHCTF1 [cytosol]
(Dictyostelium discoideum)
Ghost homologue of AHCTF1 [cytosol]
(Schizosaccharomyces pombe)
srap-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_056261.4
,
NP_001310271.1
,
XP_006711821.1
ENSEMBL
ENSP00000497061
,
ENST00000648844
,
ENSP00000355465
,
ENSP00000355464
,
ENST00000326225
,
ENST00000366508
OpenTargets
ENSG00000153207
HPA
ENSG00000153207-AHCTF1
PRO
Q8WYP5
Pharos - Targets
Q8WYP5
GlyGen
Q8WYP5
PDB
7R5J
,
7R5K
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NFH4 NUP37
2
NUP37 [nuclear envelope]
(R-HSA-157745)
NUP37 [cytosol]
(R-HSA-376237)
0.621
3
UniProt:Q9BW27 NUP85
2
NUP85 [nuclear envelope]
(R-HSA-157741)
NUP85 [cytosol]
(R-HSA-376238)
0.57
4
UniProt:Q6PFD9
9
phospho-Nup98 [cytosol]
(R-MMU-2990915)
phospho-Nup98 [cytosol]
(R-MMU-2990893)
phospho-Nup98 [nucleoplasm]
(R-MMU-2990884)
phospho-Nup98 [nucleoplasm]
(R-MMU-2990914)
phospho-Nup98 [nuclear envelope]
(R-MMU-2990895)
phospho-Nup98 [nuclear envelope]
(R-MMU-2990916)
Nup98 [nuclear envelope]
(R-MMU-2990912)
Nup98 [nuclear envelope]
(R-MMU-157723)
Nup98 [cytosol]
(R-MMU-376247)
0.564
2
UniProt:Q12769 NUP160
2
NUP160 [nuclear envelope]
(R-HSA-157721)
NUP160 [cytosol]
(R-HSA-376253)
0.488
3
UniProt:Q8NFH3 NUP43
2
NUP43 [nuclear envelope]
(R-HSA-157739)
NUP43 [cytosol]
(R-HSA-376243)
0.488
3
UniProt:P57740 NUP107
2
NUP107 [nuclear envelope]
(R-HSA-157717)
NUP107 [cytosol]
(R-HSA-376241)
0.488
3
UniProt:Q8WUM0 NUP133
2
NUP133 [nuclear envelope]
(R-HSA-157743)
NUP133 [cytosol]
(R-HSA-376251)
0.488
3
UniProt:Q96EE3 SEH1L
1
SEH1L [lysosomal membrane]
(R-HSA-9638217)
0.488
3
UniProt:P52948-PRO_0000019930 NUP98
0.488
3
UniProt:P06748 NPM1
11
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [granular component]
(R-HSA-9017702)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
0.483
2
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