Reactome | PAFAH1B1 [cytosol]

PAFAH1B1 [cytosol]

Stable Identifier

R-HSA-376249

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Lis1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P43034 PAFAH1B1

Gene Names

PAFAH1B1, LIS1, MDCR, MDS, PAFAHA

Chain

chain:1-410

Reference Genes

BioGPS Gene:5048 PAFAH1B1

COSMIC (genes):PAFAH1B1 PAFAH1B1

CTD Gene:5048 PAFAH1B1

dbSNP Gene:5048 PAFAH1B1

ENSEMBL:ENSG00000007168 PAFAH1B1

HGNC:8574 PAFAH1B1

KEGG:hsa:5048 PAFAH1B1

Monarch:5048 PAFAH1B1

NCBI Gene:5048 PAFAH1B1

OMIM:601545 PAFAH1B1

UCSC:P43034 PAFAH1B1

Reference Transcript

Other Identifiers

11716152_s_at

11716153_a_at

11746694_a_at

11746695_s_at

11747008_s_at

11748560_a_at

11755965_a_at

16829667

16829685

200813_PM_s_at

200813_s_at

200815_PM_s_at

200815_s_at

200816_PM_s_at

200816_s_at

211547_PM_s_at

211547_s_at

2500358

2500360

2500365

2500369

2500370

2563298

2563299

2563302

2563304

2563310

2563312

32569_at

3706349

3706350

3706352

3706360

3706365

3706366

3706367

3706384

3706385

3706386

3706387

3706388

3706389

3706390

3706391

3706392

3706393

3706394

3706395

3706396

3706397

3706398

3706399

3706400

3706401

3706402

3706403

3706404

3706405

3706406

3706407

3706408

3706409

3706410

3706411

3706412

3706413

3706414

3706415

3706420

3706422

3706423

3706425

5048

8003758

8003771

A_14_P122097

A_23_P118888

A_24_P113086

A_24_P356406

GE58220

GE836930

GO:0000132

GO:0000226

GO:0000235

GO:0000776

GO:0001667

GO:0001675

GO:0001764

GO:0001961

GO:0002376

GO:0005515

GO:0005634

GO:0005635

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005871

GO:0005874

GO:0005875

GO:0005881

GO:0005929

GO:0005938

GO:0006629

GO:0007010

GO:0007017

GO:0007018

GO:0007097

GO:0007254

GO:0007268

GO:0007281

GO:0007399

GO:0007405

GO:0007611

GO:0008017

GO:0008090

GO:0008092

GO:0008201

GO:0008247

GO:0008344

GO:0009306

GO:0010977

GO:0015630

GO:0016020

GO:0016042

GO:0016477

GO:0017145

GO:0019226

GO:0021540

GO:0021766

GO:0021819

GO:0021895

GO:0021987

GO:0022414

GO:0023052

GO:0030036

GO:0030154

GO:0030424

GO:0030426

GO:0031023

GO:0031252

GO:0031514

GO:0031965

GO:0031982

GO:0032420

GO:0034452

GO:0036035

GO:0038026

GO:0040019

GO:0042249

GO:0042802

GO:0043005

GO:0043025

GO:0043226

GO:0043229

GO:0043274

GO:0043622

GO:0044877

GO:0045505

GO:0045773

GO:0045931

GO:0046329

GO:0046469

GO:0046982

GO:0047496

GO:0048471

GO:0048854

GO:0048856

GO:0048870

GO:0050804

GO:0050877

GO:0050885

GO:0051010

GO:0051012

GO:0051081

GO:0051130

GO:0051219

GO:0051301

GO:0051649

GO:0051660

GO:0051661

GO:0060117

GO:0061003

GO:0061024

GO:0070062

GO:0070507

GO:0070840

GO:0090102

GO:0090176

GO:0090724

GO:0097529

GO:0098685

GO:0098978

GO:0099175

GO:0140650

GO:1904115

GO:1904936

HMNXSV003008234

Hs.77318.0.A2_3p_a_at

ILMN_1722276

PH_hs_0004456

TC17000024.hg

TC17002011.hg

U72342_at

g349825_3p_a_at

g349827_3p_a_at

g6031206_3p_a_at

p20244

Participates

as a component of

as an output of

RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Homo sapiens)

Inferred To

Lis-1 [cytosol] (Drosophila melanogaster)

lis-1 [cytosol] (Caenorhabditis elegans)

PAFAH1B1 [cytosol] (Bos taurus)

PAFAH1B1 [cytosol] (Canis familiaris)

PAFAH1B1 [cytosol] (Gallus gallus)

PAFAH1B1 [cytosol] (Sus scrofa)

Pafah1b1 [cytosol] (Mus musculus)

Pafah1b1 [cytosol] (Rattus norvegicus)

pafah1b1b [cytosol] (Danio rerio)

pafah1b1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_000421.1, XP_016880190.1, XP_016880188.1, XP_016880189.1

OpenTargets

ENSG00000007168

ENSEMBL

ENSP00000502577, ENST00000676188, ENST00000675331, ENST00000675202, ENSP00000502843, ENSP00000502735, ENSP00000502031, ENSP00000501969, ENSP00000380378, ENST00000397195, ENST00000675390, ENST00000676098

HPA

ENSG00000007168-PAFAH1B1

PRO

P43034

Pharos - Targets

P43034

Orphanet

PAFAH1B1

GlyGen

P43034

HMDB Protein

HMDBP00556

PDB

8PTK, 8FDT, 8PQW, 8FDU, 8DYV, 7MT1, 8DYU, 8PQY, 8PQZ

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9GZM8 NDEL1	1	NDEL1 [cytosol] (R-HSA-376258)	0.73	7
UniProt:Q14204 DYNC1H1	3	DYNC1H1 [cytosol] (R-HSA-380285) DYNC1H1 [azurophil granule lumen] (R-HSA-6799155) DYNC1H1 [extracellular region] (R-HSA-6806223)	0.725	4
UniProt:P68402 PAFAH1B2	4	PAFAH1B2 [cytosol] (R-HSA-8848133) PAFAH1B2 [ficolin-1-rich granule lumen] (R-HSA-6803294) PAFAH1B2 [extracellular region] (R-HSA-6806497) PAFAH1B2 [secretory granule lumen] (R-HSA-6803298)	0.704	4
UniProt:Q9CZA6	1	Nde1 [cytosol] (R-MMU-376257)	0.646	6
UniProt:Q15102 PAFAH1B3	1	PAFAH1B3 [cytosol] (R-HSA-8848134)	0.641	3
UniProt:Q13409 DYNC1I2	1	DYNC1I2 [cytosol] (R-HSA-201607)	0.638	3
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.638	3
UniProt:Q9Y6G9 DYNC1LI1	4	DYNC1LI1 [secretory granule membrane] (R-HSA-6801371) DYNC1LI1 [plasma membrane] (R-HSA-6801598) DYNC1LI1 [ficolin-1-rich granule membrane] (R-HSA-6801381) DYNC1LI1 [cytosol] (R-HSA-8943213)	0.638	3
UniProt:Q8WVJ2 NUDC2			0.637	8
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.612	5
UniProt:Q9NRI5 DISC1			0.573	2
UniProt:Q9ERR1	1	Ndel1 [cytosol] (R-MMU-376258)	0.527	2
UniProt:Q8IVD9 NUDC3			0.524	2
UniProt:P63172 DYNLT1	3	DYNLT1 [ficolin-1-rich granule lumen] (R-HSA-6801487) DYNLT1 [extracellular region] (R-HSA-6806509) DYNLT1 [secretory granule lumen] (R-HSA-6801497)	0.508	2
UniProt:Q9NXR1 NDE1	1	NDE1 [cytosol] (R-HSA-376257)	0.508	2
UniProt:P51808 DYLT3			0.508	2
UniProt:Q9NWU2 GID8	1	GID8 [cytosol] (R-HSA-9861665)	0.508	2
UniProt:Q8TF09 DYNLRB2	2	DYNLRB2 [ciliary tip] (R-HSA-5625341) DYNLRB2 [cilium] (R-HSA-5624869)	0.508	2
UniProt:Q14203 DCTN1	7	DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711969) DCTN1(1-599)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711960) DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol] (R-HSA-9701997) DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711959) DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711953) DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711962) DCTN1 [cytosol] (R-HSA-535580)	0.48	2

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