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CLASP2 [cytosol]
Stable Identifier
R-HSA-376252
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Clasp2
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Role of ABL in ROBO-SLIT signaling (Homo sapiens)
Activation of CLASP (Homo sapiens)
CLASP [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
SLIT2:ROBO1:ABL:CLASP [plasma membrane] (Homo sapiens)
CLASP [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CLASP2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75122 CLASP2
Gene Names
CLASP2, KIAA0627
Chain
chain:1-1294
Reference Genes
BioGPS Gene:23122 CLASP2
COSMIC (genes):CLASP2 CLASP2
CTD Gene:23122 CLASP2
dbSNP Gene:23122 CLASP2
ENSEMBL:ENSG00000163539 CLASP2
HGNC:17078 CLASP2
KEGG:hsa:23122 CLASP2
Monarch:23122 CLASP2
NCBI Gene:23122 CLASP2
OMIM:605853 CLASP2
UCSC:O75122 CLASP2
Reference Transcript
RefSeq:NM_015097.2 CLASP2
RefSeq:NM_001207044.1 CLASP2
Other Identifiers
11733858_a_at
11733859_s_at
11733860_a_at
11733861_s_at
11747920_a_at
11756192_a_at
11759783_a_at
11763488_a_at
11763699_a_at
1555469_PM_a_at
1555469_a_at
1558759_PM_s_at
1558759_s_at
16952031
212306_PM_at
212306_at
212308_PM_at
212308_at
212309_PM_at
212309_at
23122
2668426
2668427
2668428
2668429
2668430
2668431
2668434
2668435
2668436
2668437
2668438
2668440
2668441
2668442
2668443
2668448
2668449
2668452
2668454
2668455
2668459
2668462
2668463
2668464
2668465
2668466
2668470
2668471
2668472
2668474
2668475
2668481
2668482
2668483
2668485
2668487
2668492
2668493
2668494
2668495
2668496
2668498
2668504
2668505
2668506
2668507
2668510
2668511
2668515
2668516
2668517
2668518
2668519
2668522
2668523
2668524
2668525
2668528
2668529
2668530
2668532
2668535
2668536
2668537
2668538
2668539
2668540
2668541
2668542
2668547
2668548
38711_at
49920_at
54177_i_at
64337_f_at
8086077
88655_at
A_23_P369574
A_23_P44295
A_24_P127748
A_24_P932319
GE53343
GO:0000226
GO:0000775
GO:0000776
GO:0002162
GO:0005515
GO:0005694
GO:0005737
GO:0005794
GO:0005802
GO:0005813
GO:0005815
GO:0005819
GO:0005828
GO:0005829
GO:0005856
GO:0005874
GO:0005876
GO:0005881
GO:0005886
GO:0005925
GO:0005938
GO:0006903
GO:0007010
GO:0007020
GO:0007026
GO:0007030
GO:0007052
GO:0007163
GO:0008017
GO:0008092
GO:0010458
GO:0010470
GO:0010634
GO:0010717
GO:0015630
GO:0015631
GO:0016020
GO:0030516
GO:0031023
GO:0031110
GO:0031113
GO:0031252
GO:0032587
GO:0032886
GO:0032956
GO:0034453
GO:0040001
GO:0042995
GO:0043226
GO:0044295
GO:0045180
GO:0045921
GO:0051010
GO:0051301
GO:0051494
GO:0051497
GO:0051895
GO:0072659
GO:0072686
GO:0090091
GO:0090307
GO:0098978
GO:0099187
GO:1902904
GO:1903690
GO:1903754
GO:1904261
GO:1990782
HMNXSV003009844
HMNXSV003049021
Hs.108614.0.S1_3p_at
Hs.108614.0.S2_3p_at
Hs.108614.0.S3_3p_at
Hs.108614.0.S3_3p_x_at
Hs2.108614.1.S1_3p_s_at
Hs2.108614.5.S1_3p_s_at
ILMN_1770548
PH_hs_0006013
TC03001277.hg
Participates
as a member of
CLASP [cytosol] (Homo sapiens)
as a component of
Kinetochore [cytosol] (Homo sapiens)
Inferred To
CLASP2 [cytosol]
(Bos taurus)
CLASP2 [cytosol]
(Canis familiaris)
CLASP2 [cytosol]
(Gallus gallus)
CLASP2 [cytosol]
(Sus scrofa)
Ghost homologue of CLASP2 [cytosol]
(Xenopus tropicalis)
Clasp2 [cytosol]
(Mus musculus)
Clasp2 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001193973.1
,
NP_055912.2
ENSEMBL
ENSP00000324364
,
ENST00000480013
,
ENSP00000417518
,
ENST00000313350
OpenTargets
ENSG00000163539
HPA
ENSG00000163539-CLASP2
PRO
O75122
Pharos - Targets
O75122
GlyGen
O75122
PDB
3WOY
,
5NR4
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.745
8
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.671
6
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.649
8
UniProt:P49841 GSK3B
4
GSK3B [cytosol]
(R-HSA-2997551)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [nucleoplasm]
(R-HSA-2022823)
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
0.527
2
UniProt:Q02224 CENPE
1
CENPE [cytosol]
(R-HSA-376245)
0.527
2
UniProt:Q9HC77 CENPJ
2
CENPJ [cytosol]
(R-HSA-380291)
p-S589,S595-CENPJ [cytosol]
(R-HSA-6801670)
0.527
2
UniProt:Q14203 DCTN1
7
DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711969)
DCTN1(1-599)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711960)
DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9701997)
DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711959)
DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711953)
DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711962)
DCTN1 [cytosol]
(R-HSA-535580)
0.483
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.471
4
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