Reactome | RANGAP1 [cytosol]

RANGAP1 [cytosol]

Stable Identifier

R-HSA-376255

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RanGap1

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Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Amplification of signal from the kinetochores (Homo sapiens)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
        
        MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        Mad1 binds kinetochore (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        Release of activated MAD2 from kinetochores (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        Separation of sister chromatids (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - EML4 and NUDC in mitotic spindle formation (Homo sapiens)
        
        EML4 recruits NUDC to mitotic spindle (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
      - Kinetochore capture of astral microtubules (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        Kinetochore assembly (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RANGAP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P46060 RANGAP1

Gene Names

RANGAP1, KIAA1835, SD

Chain

initiator methionine:, chain:2-587

Reference Genes

BioGPS Gene:5905 RANGAP1

COSMIC (genes):RANGAP1 RANGAP1

CTD Gene:5905 RANGAP1

dbSNP Gene:5905 RANGAP1

ENSEMBL:ENSG00000100401 RANGAP1

ENSEMBL_homo_sapiens_GENE:ENSG00000100401.21 RANGAP1

HGNC:9854 RANGAP1

KEGG Gene (Homo sapiens):5905 RANGAP1

Monarch:5905 RANGAP1

NCBI Gene:5905 RANGAP1

OMIM:602362 RANGAP1

UCSC:P46060 RANGAP1

Reference Transcript

Other Identifiers

11717164_a_at

11717165_a_at

1553535_PM_a_at

1553535_a_at

16935396

212125_PM_at

212125_at

212127_PM_at

212127_at

32151_at

3961843

3961844

3961845

3961846

3961847

3961848

3961851

3961852

3961855

3961857

3961858

3961859

3961860

3961862

3961864

3961865

3961869

3961872

3961873

3961874

3961876

3961877

3961878

3961879

3961880

3961881

3961883

3961885

3961886

3961887

3961888

3961889

5905

8076307

A_23_P333420

A_33_P3263307

GE62508

GO:0000775

GO:0000776

GO:0003723

GO:0005096

GO:0005515

GO:0005634

GO:0005635

GO:0005643

GO:0005654

GO:0005694

GO:0005737

GO:0005819

GO:0005829

GO:0005856

GO:0006886

GO:0006913

GO:0007165

GO:0016235

GO:0016925

GO:0023052

GO:0030425

GO:0031267

GO:0031625

GO:0031965

GO:0036211

GO:0043226

GO:0043231

GO:0044614

GO:0045296

GO:0046826

GO:0048471

GO:0048678

GO:0051168

GO:0071375

GO:0072686

GO:0090630

GO:0098772

GO:0106068

GO:1904115

GO:1904117

GO:1990723

HMNXSV003050468

Hs.183800.0.S1_3p_at

Hs.183800.0.S2_3p_at

Hs2.183800.1.S1_3p_s_at

ILMN_1662198

PH_hs_0029369

RNA95835|RNS_917_108

TC22000823.hg

Participates

as a component of

Kinetochore [cytosol] (Homo sapiens)

Other forms of this molecule

RANGAP1 [nuclear envelope]

monoSUMO1-K524-RANGAP1 [nuclear envelope]

Inferred To

Rangap1 [cytosol] (Mus musculus)

Rangap1 [cytosol] (Rattus norvegicus)

RANGAP1 [cytosol] (Bos taurus)

RANGAP1 [cytosol] (Gallus gallus)

RANGAP1 [cytosol] (Sus scrofa)

CHADL [cytosol] (Canis familiaris)

rangap1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_016884383.1, XP_016884386.1, NP_001265580.1, XP_016884382.1, NP_002874.1, XP_016884384.1, XP_006724352.1, XP_016884385.1, XP_011528596.1, XP_011528597.1, NP_001304859.1

OpenTargets

ENSG00000100401

GeneCards

P46060

HPA

ENSG00000100401-RANGAP1

Ensembl

ENST00000405486, ENST00000705116, ENSP00000516069, ENSP00000401470, ENSP00000385866, ENSP00000348577, ENST00000455915, ENSG00000100401, ENST00000356244

PRO

P46060

Pharos - Targets

P46060

PDB

3UIN, 1Z5S, 2GRR, 3UIP, 2IO2, 2GRP, 3UIO, 5D2M, 2IO3, 2IY0, 2GRQ, 2GRN, 2GRO

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) SUMO1 [nucleoplasm] (R-HSA-877304) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.962	14
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481)	0.95	15
UniProt:P61956 SUMO2	6	lysyl-G93-SUMO2 [cytosol] (R-HSA-9834803) SUMO2(1-95) [nucleoplasm] (R-HSA-2990837) UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618) SUMO2 [nucleoplasm] (R-HSA-2984281) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm] (R-HSA-9761546)	0.75	6
UniProt:P49792 RANBP2	6	polySUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720) monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) RANBP2 [nuclear envelope] (R-HSA-2993756) RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9718443) RANBP2(1-867)-ALK(1058-1620) fusion [cytosol] (R-HSA-9702002) RANBP2 [cytosol] (R-HSA-157703)	0.713	5
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.643	4
UniProt:Q9P0U3 SENP1	2	SENP1 [cytosol] (R-HSA-9715128) SENP1 [nucleoplasm] (R-HSA-2984299)	0.591	4
UniProt:Q9HC62 SENP2	1	SENP2 [nucleoplasm] (R-HSA-2984298)	0.591	6
UniProt:Q9ERU9 Ranbp2	5	Ranbp2 [nuclear envelope] (R-MMU-4551720) Ranbp2 [nuclear envelope] (R-MMU-4551599) Ranbp2 [nuclear envelope] (R-MMU-5228524) Ranbp2 [nuclear envelope] (R-MMU-2993756) Ranbp2 [cytosol] (R-MMU-157703)	0.564	2
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q9UBU9 NXF1	2	NXF1 [cytosol] (R-HSA-156481) NXF1 [nucleoplasm] (R-HSA-111690)	0.527	2
UniProt:P61769 B2M	11	B2M(21-119) [early endosome membrane] (R-HSA-182298) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [plasma membrane] (R-HSA-167743)	0.527	4
UniProt:O14524 NEMP1			0.527	3
UniProt:Q14974 KPNB1	5	KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [cytosol] (R-HSA-180733)	0.527	2
UniProt:P05412 JUN	4	p-S63,S73-JUN [cytosol] (R-HSA-8868682) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194)	0.462	2