Reactome | NDEL1 [cytosol]

NDEL1 [cytosol]

Stable Identifier

R-HSA-376258

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Amplification of signal from the kinetochores (Homo sapiens)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
        
        MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        Mad1 binds kinetochore (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        Release of activated MAD2 from kinetochores (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        Separation of sister chromatids (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - EML4 and NUDC in mitotic spindle formation (Homo sapiens)
        
        EML4 recruits NUDC to mitotic spindle (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
      - Kinetochore capture of astral microtubules (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        Kinetochore assembly (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        NDEL1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9GZM8 NDEL1

Gene Names

NDEL1, EOPA, MITAP1, NUDEL

Chain

chain:1-345

Reference Genes

BioGPS Gene:81565 NDEL1

COSMIC (genes):NDEL1 NDEL1

CTD Gene:81565 NDEL1

dbSNP Gene:81565 NDEL1

ENSEMBL:ENSG00000166579.16 NDEL1

HGNC:17620 NDEL1

KEGG Gene (Homo sapiens):81565 NDEL1

Monarch:81565 NDEL1

NCBI Gene:81565 NDEL1

OMIM:607538 NDEL1

UCSC:Q9GZM8 NDEL1

Reference Transcript

Other Identifiers

0000870180

11721513_a_at

11736169_a_at

16830988

208093_PM_s_at

208093_s_at

34413_at

3709692

3709693

3709699

3709701

3709702

3709703

3709705

3709708

3709709

3709713

3709715

3709716

3709717

3709718

8004867

81565

A_23_P26878

A_33_P3244141

A_33_P3327852

GE54321

GE86645

GO:0000132

GO:0000226

GO:0000278

GO:0000775

GO:0000776

GO:0001764

GO:0001833

GO:0005515

GO:0005622

GO:0005634

GO:0005635

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005871

GO:0005874

GO:0005875

GO:0006886

GO:0007010

GO:0007018

GO:0007020

GO:0007059

GO:0007100

GO:0007163

GO:0007399

GO:0008017

GO:0008021

GO:0008090

GO:0008092

GO:0008286

GO:0010975

GO:0016477

GO:0016787

GO:0021799

GO:0021955

GO:0023052

GO:0030154

GO:0030424

GO:0031175

GO:0031252

GO:0031410

GO:0032418

GO:0032991

GO:0033157

GO:0042802

GO:0043014

GO:0043203

GO:0043226

GO:0043547

GO:0044297

GO:0044877

GO:0045773

GO:0047496

GO:0048487

GO:0048680

GO:0048856

GO:0048870

GO:0051081

GO:0051303

GO:0051642

GO:0060052

GO:0060053

GO:0061024

GO:0065003

GO:0070012

GO:0090630

GO:0090724

GO:0140014

GO:0140096

GO:0140650

GO:1900029

GO:1904115

GO:1990138

HMNXSV003006705

HMNXSV003032050

ILMN_1705064

ILMN_2397199

PH_hs_0000435

TC17000141.hg

g13540599_3p_s_at

Participates

as a component of

Kinetochore [cytosol] (Homo sapiens)

Inferred To

ndel1b [cytosol] (Danio rerio)

NDEL1 [cytosol] (Bos taurus)

NDEL1 [cytosol] (Canis familiaris)

NDEL1 [cytosol] (Gallus gallus)

NDEL1 [cytosol] (Sus scrofa)

ndel1 [cytosol] (Xenopus tropicalis)

Ndel1 [cytosol] (Mus musculus)

Ndel1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_110435.1, XP_016880676.1, XP_016880674.1, NP_001020750.1

OpenTargets

ENSG00000166579

HPA

ENSG00000166579-NDEL1

GeneCards

Q9GZM8

Ensembl

ENSP00000333982, ENSG00000166579, ENSP00000384963, ENST00000334527, ENST00000402554

PRO

Q9GZM8

Pharos - Targets

Q9GZM8

PDB

2V66

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63005	1	Pafah1b1 [cytosol] (R-MMU-376249)	0.779	4
UniProt:P49454 CENPF	1	CENPF [cytosol] (R-HSA-376229)	0.75	6
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.74	7
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.718	6
UniProt:P23025 XPA	1	XPA [nucleoplasm] (R-HSA-67437)	0.718	6
UniProt:P43034 PAFAH1B1	1	PAFAH1B1 [cytosol] (R-HSA-376249)	0.641	4
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:Q9Y6A5 TACC3	1	TACC3 [cytosol] (R-HSA-2160956)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:O60229 KALRN	2	p-KALRN [cytosol] (R-HSA-5692652) KALRN [cytosol] (R-HSA-3006505)	0.553	2

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