Reactome | NR0B2 [nucleoplasm]

NR0B2 [nucleoplasm]

Stable Identifier

R-HSA-376312

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

NR0B2_HUMAN, Nuclear receptor subfamily 0 group B member 2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q15466 NR0B2

Gene Names

NR0B2, SHP

Chain

chain:1-257

Reference Genes

BioGPS Gene:8431 NR0B2

COSMIC (genes):NR0B2 NR0B2

CTD Gene:8431 NR0B2

dbSNP Gene:8431 NR0B2

ENSEMBL:ENSG00000131910 NR0B2

ENSEMBL_homo_sapiens_GENE:ENSG00000131910.5 NR0B2

HGNC:7961 NR0B2

KEGG Gene (Homo sapiens):8431 NR0B2

Monarch:8431 NR0B2

NCBI Gene:8431 NR0B2

OMIM:604630 NR0B2

UCSC:Q15466 NR0B2

Reference Transcript

RefSeq:NM_021969.2 NR0B2

Other Identifiers

11726231_at

16683903

206410_PM_at

206410_at

2402884

2402885

2402886

2402888

2402889

37505_at

643_at

7914000

8431

A_23_P160800

GE61812

GO:0000122

GO:0000785

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006351

GO:0006355

GO:0006629

GO:0007219

GO:0007623

GO:0008203

GO:0009749

GO:0010628

GO:0010629

GO:0014070

GO:0015721

GO:0019904

GO:0023052

GO:0031100

GO:0032024

GO:0032922

GO:0032991

GO:0042803

GO:0042974

GO:0042975

GO:0043226

GO:0043231

GO:0043433

GO:0044877

GO:0045471

GO:0045892

GO:0045893

GO:0046965

GO:0046966

GO:0048511

GO:0048856

GO:0098772

GO:0140110

GO:0140416

HMNXSV003055284

ILMN_2220978

L76571_at

PH_hs_0019848

TC01002398.hg

g13259502_3p_at

Participates

as a member of

NR [nucleoplasm] (Homo sapiens)

Inferred To

NR0B2 [nucleoplasm] (Bos taurus)

NR0B2 [nucleoplasm] (Canis familiaris)

NR0B2 [nucleoplasm] (Gallus gallus)

NR0B2 [nucleoplasm] (Sus scrofa)

Nr0b2 [nucleoplasm] (Mus musculus)

Nr0b2 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_068804.1

Guide to Pharmacology - Targets

636

OpenTargets

ENSG00000131910

ZINC - Substances

NR0B2_HUMAN

ZINC target

Q15466

PRO

Q15466

PDB

7YXC, 1YUC, 7YXP, 4DOR, 6W9M, 7YXO, 5UFS, 2Q3Y, 2Z4J, 7YXD, 4ONI, 7YXR, 7YXN

GeneCards

Q15466

HPA

ENSG00000131910-NR0B2

Ensembl

ENST00000254227, ENSP00000254227, ENSG00000131910

Pharos - Targets

Q15466

ZINC - Predictions - Purchasable

NR0B2_HUMAN

Orphanet

28945

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.61	6
UniProt:O00482-1 NR5A2	1	NR5A2-1 [nucleoplasm] (R-HSA-3008758)	0.558	2
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.524	3
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.524	4
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.499	2
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.499	2

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