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Go!
SOST [extracellular region]
Stable Identifier
R-HSA-3769322
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Sclerostin
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Negative regulation of TCF-dependent signaling by WNT ligand antagonists (Homo sapiens)
SOST binds LRP5/6 (Homo sapiens)
SOST [extracellular region] (Homo sapiens)
SOST:LRP5/6 [plasma membrane] (Homo sapiens)
SOST [extracellular region] (Homo sapiens)
WNT binds to FZD and LRP5/6 (Homo sapiens)
SOST [extracellular region] (Homo sapiens)
SOST:LRP5/6 [plasma membrane] (Homo sapiens)
SOST [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BQB4 SOST
Gene Names
SOST, UNQ2976/PRO7455/PRO7476
Chain
signal peptide:1-23, chain:24-213
Reference Genes
BioGPS Gene:50964 SOST
COSMIC (genes):SOST SOST
CTD Gene:50964 SOST
dbSNP Gene:50964 SOST
ENSEMBL:ENSG00000167941 SOST
ENSEMBL_homo_sapiens_GENE:ENSG00000167941.3 SOST
HGNC:13771 SOST
KEGG Gene (Homo sapiens):50964 SOST
Monarch:50964 SOST
NCBI Gene:50964 SOST
OMIM:605740 SOST
UCSC:Q9BQB4 SOST
Reference Transcript
RefSeq:NM_025237.2 SOST
Other Identifiers
11727328_at
11727329_at
16845440
223869_PM_at
223869_at
3758607
3758608
3758613
50964
77335_at
8015827
A_23_P118571
GE83138
GO:0001503
GO:0005515
GO:0005576
GO:0005615
GO:0005794
GO:0006351
GO:0006355
GO:0008201
GO:0009612
GO:0016055
GO:0023052
GO:0030178
GO:0030246
GO:0030279
GO:0030312
GO:0030509
GO:0030514
GO:0031012
GO:0031333
GO:0032991
GO:0036122
GO:0043226
GO:0045893
GO:0051179
GO:0060070
GO:0062023
GO:0065003
GO:0071374
GO:0090090
GO:0098772
GO:0140297
GO:0140678
HMNXSV003054420
ILMN_1700705
ILMN_1781242
PH_hs_0016850
TC17001562.hg
g13236417_3p_at
Participates
as an input of
SOST binds LRP5/6 (Homo sapiens)
as a component of
SOST:LRP5/6 [plasma membrane] (Homo sapiens)
Inferred To
SOST [extracellular region]
(Bos taurus)
SOST [extracellular region]
(Gallus gallus)
SOST [extracellular region]
(Sus scrofa)
Sost [extracellular region]
(Mus musculus)
Sost [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_079513.1
OpenTargets
ENSG00000167941
GeneCards
Q9BQB4
HPA
ENSG00000167941-SOST
Ensembl
ENSG00000167941
,
ENST00000301691
,
ENSP00000301691
PRO
Q9BQB4
Pharos - Targets
Q9BQB4
Orphanet
16450
PDB
2K8P
,
6L6R
,
3SOV
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75581 LRP6
8
p-T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-205884)
p-S1490-LRP6 [plasma membrane]
(R-HSA-206156)
LRP6 [early endosome membrane]
(R-HSA-5368481)
p-LRP6 [early endosome membrane]
(R-HSA-5368496)
LRP6N [extracellular region]
(R-HSA-5334021)
p-2S,S1490,2T-LRP6 [plasma membrane]
(R-HSA-1458894)
p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-1458895)
LRP6 [plasma membrane]
(R-HSA-206252)
0.806
7
UniProt:O75096 LRP4
1
LRP4 [plasma membrane]
(R-HSA-2467621)
0.724
5
UniProt:O75197 LRP5
5
LRP5 D666_L809del [plasma membrane]
(R-HSA-5339694)
LRP5 [early endosome membrane]
(R-HSA-5368479)
p-3S,2T-LRP5 [plasma membrane]
(R-HSA-1458905)
p-5S,5T-LRP5 [plasma membrane]
(R-HSA-1458893)
LRP5 [plasma membrane]
(R-HSA-201671)
0.669
3
UniProt:Q9H8W4 PKHF2
0.556
3
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