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YWHAZ binds p-CBY:CTNNB1
Stable Identifier
R-HSA-3769393
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
YWHAZ binds p-CBY:CTNNB1 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
14-3-3 proteins, represented here as YWHAZ, bind directly to CBY1 after AKT-dependent phosphorylation of CBY1 serine 20. Tagged versions of beta-catenin, CBY1 and 14-3-3/YWHAZ expressed in HEK293 cells co-immunoprecipitate in a CBY1-phosphorylation dependent manner. 14-3-3/YWHAZ binding promotes sequestration of CBY1 and beta-catenin in the cytoplasm, thus antagonizing beta-catenin-dependent transcription (Li et al, 2008).
Literature References
PubMed ID
Title
Journal
Year
18573912
Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity
Mofunanya, A
,
Harris, K
,
Takemaru, K
,
Li, FQ
J. Cell Biol.
2008
Participants
Input
pS20-CBY1:CTNNB1 [nucleoplasm]
(Homo sapiens)
YWHAZ [nucleoplasm]
(Homo sapiens)
Output
YWHAZ:p-S20-CBY:CTNNB1 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
Orthologous Events
YWHAZ binds p-CBY:CTNNB1 (Bos taurus)
YWHAZ binds p-CBY:CTNNB1 (Canis familiaris)
YWHAZ binds p-CBY:CTNNB1 (Danio rerio)
YWHAZ binds p-CBY:CTNNB1 (Drosophila melanogaster)
YWHAZ binds p-CBY:CTNNB1 (Gallus gallus)
YWHAZ binds p-CBY:CTNNB1 (Mus musculus)
YWHAZ binds p-CBY:CTNNB1 (Rattus norvegicus)
YWHAZ binds p-CBY:CTNNB1 (Xenopus tropicalis)
Authored
Rothfels, K (2013-05-30)
Reviewed
Rajakulendran, N (2014-01-22)
van Amerongen, R (2014-02-15)
Kikuchi, A (2014-04-22)
Created
Rothfels, K (2013-06-20)
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