CBY1 is phosphorylated in vitro at serine 20 by AKT1 and AKT2. In vivo, this phosphorylation is required for the export of beta-catenin from the nucleus, facilitated by the binding of 14-3-3/YWHAZ proteins to the pS20 residue of CBY1 (Li et al, 2008).
Mofunanya, A, Harris, K, Takemaru, K, Li, FQ
protein serine/threonine kinase activity of p-AKT1/2 [nucleoplasm]
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