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PDPK1:PIP3 [plasma membrane]
Stable Identifier
R-HSA-377179
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
PDK1:PIP3
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 targets host intracellular signalling and regulatory pathways (Homo sapiens)
PDPK1 phosphorylates AKT at T308 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
PDPK1 phosphorylates SGK1 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
PDPK1 activates PRKCZ (Homo sapiens)
PDPK1:PIP3:PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1 binds PRKCZ (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3:PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PIP3 recruits PDPK1 to the membrane (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-stimulation by CD28 (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
AKT binds PDPK1 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1 phosphorylates AKT at T308 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PIP3 recruits PDPK1 to the membrane (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
RSK activation (Homo sapiens)
PDPK1 phosphorylates RSKs (Homo sapiens)
PDPK1:PIP3,PDPK1:PIP2 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
AKT binds PDPK1 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1 phosphorylates AKT at T308 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1 phosphorylates SGK1 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PIP3 recruits PDPK1 to the membrane (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
Estrogen-stimulated signaling through PRKCZ (Homo sapiens)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1 activates PRKCZ (Homo sapiens)
PDPK1:PIP3:PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1 binds PRKCZ (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3:PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PRKCZ autophosphorylates downstream of estrogen stimulation (Homo sapiens)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PRKCZ recruits RAS in response to estrogen stimulation (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
Activation of AKT2 (Homo sapiens)
PDPK1 phosphorylates AKT2 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
Activation of AKT2 (Homo sapiens)
PDPK1 phosphorylates AKT2 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
AKT binds PDPK1 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1 phosphorylates AKT at T308 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PIP3 recruits PDPK1 to the membrane (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
PDPK1 phosphorylates PKN1,2,3 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
PDPK1:PIP3 [plasma membrane] (Homo sapiens)
Participants
components
PDPK1 [plasma membrane]
(Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Participates
as an input of
PDPK1 binds PRKCZ (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Homo sapiens)
AKT binds PDPK1 (Homo sapiens)
as a component of
PDPK1:PIP3:PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
as an output of
PDPK1 phosphorylates PKN1,2,3 (Homo sapiens)
PIP3 recruits PDPK1 to the membrane (Homo sapiens)
PDPK1 phosphorylates AKT at T308 (Homo sapiens)
as a member of
PDPK1:PIP3,PDPK1:PIP2 [plasma membrane] (Homo sapiens)
Inferred To
PDPK1:PIP3 [plasma membrane]
(Bos taurus)
PDPK1:PIP3 [plasma membrane]
(Caenorhabditis elegans)
PDPK1:PIP3 [plasma membrane]
(Canis familiaris)
PDPK1:PIP3 [plasma membrane]
(Danio rerio)
PDPK1:PIP3 [plasma membrane]
(Dictyostelium discoideum)
PDPK1:PIP3 [plasma membrane]
(Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane]
(Gallus gallus)
PDPK1:PIP3 [plasma membrane]
(Mus musculus)
PDPK1:PIP3 [plasma membrane]
(Plasmodium falciparum)
PDPK1:PIP3 [plasma membrane]
(Rattus norvegicus)
PDPK1:PIP3 [plasma membrane]
(Saccharomyces cerevisiae)
PDPK1:PIP3 [plasma membrane]
(Schizosaccharomyces pombe)
PDPK1:PIP3 [plasma membrane]
(Sus scrofa)
PDPK1:PIP3 [plasma membrane]
(Xenopus tropicalis)
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