Reactome | Activated Akt1 phosphorylates AKT1S1 (PRAS40)

Activated Akt1 phosphorylates AKT1S1 (PRAS40)

Stable Identifier

R-HSA-377186

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lysosomal membrane, cytosol

ReviewStatus

5/5

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Activated Akt1 phosphorylates AKT1S1 (PRAS40)

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AKT1 phosphorylates AKT1S1 (PRAS40, Proline Rich Akt Substrate 40 kDa) at Thr-246. AKT1S1 is an inhibitory accessory protein of mTORC1. Phosphorylation of AKT1S1 by AKT releases the inhibition of mTORC1.

Literature References

PubMed ID	Title	Journal	Year
17517883	The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1 Oshiro, N, Takahashi, R, Yoshino, K, Tanimura, K, Nakashima, A, Eguchi, S, Miyamoto, T, Hara, K, Takehana, K, Avruch, J, Kikkawa, U, Yonezawa, K	J Biol Chem	2007
18372248	Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation Wang, L, Harris, TE, Lawrence JC, Jr	J Biol Chem	2008
12524439	Identification of a proline-rich Akt substrate as a 14-3-3 binding partner Kovacina, KS, Park, GY, Bae, SS, Guzzetta, AW, Schaefer, E, Birnbaum, MJ, Roth, RA	J Biol Chem	2003
17277771	Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 Vander Haar, E, Lee, SI, Bandhakavi, S, Griffin, TJ, Kim, DH	Nat Cell Biol	2007
17386266	PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase Sancak, Y, Thoreen, CC, Peterson, TR, Lindquist, RA, Kang, SA, Spooner, E, Carr, SA, Sabatini, DM	Mol Cell	2007