Reactome | Phosphorylated DVL recruits PIP5K1B to the plasma membrane

Phosphorylated DVL recruits PIP5K1B to the plasma membrane

Stable Identifier

R-HSA-3772434

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Phosphorylated DVL recruits PIP5K1B to the plasma membrane

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DVL1 and 3 have been shown to co-immunoprecipitate with PIP5KB in HEK293 cells. This interaction is mediated by the N-terminal half of the kinase and the PDZ and DIX domain of DVL and recruits PIPK5B to the receptor complex. The interaction of DVL and PIP5KB is required for the WNT3A-dependent phosphorylation of LRP6 at serine 1490 and threonine 1479, as well as and the subsequent formation of the signalosome and recruitment of AXIN (Pan et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
18772438	Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation Lucast, L, Zhang, X, Choi, SC, Swan, L, Abrams, CS, Sokol, SY, Wu, D, Pan, W, Li, L, Volpicelli-Daley, L, Wang, H, Qin, Y, Khoo, C	Science	2008