Reactome | WNT signaling stimulates CSNK1-dependent phosphorylation of DVL

WNT signaling stimulates CSNK1-dependent phosphorylation of DVL

Stable Identifier

R-HSA-3772435

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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WNT signaling stimulates CSNK1-dependent phosphorylation of DVL

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CSNK1E and DVL physically interact in vivo and CSNK1E phosphorylates DVL in response to WNT signaling (Peters et al, 1999; Sakanaka et al, 1999; Kishida et al, 2001; Gao et al, 2002; Hino et al, 2003; Klimowski et al, 2006; Bernatik et al, 2011). Phosphorylation by CSNK1E in the PDZ domain of DVL appears to be required for the recruitment of AXIN and the subsequent phosphorylation of LRP6 (Bernatik et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
11425858	Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon Kishida, M, Kikuchi, A, Asashima, M, Hino, S, Kishida, S, Michiue, T, Fukui, A, Yamamoto, H	J. Biol. Chem.	2001
10517632	Casein kinase I transduces Wnt signals Peters, JM, McKay, JP, McKay, RM, Graff, JM	Nature	1999
16965538	Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling Garcia, BA, Shabanowitz, J, Virshup, DM, Klimowski, LK, Hunt, DF	FEBS J.	2006
12556519	Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin Kikuchi, A, Asashima, M, Hino, S, Michiue, T	J. Biol. Chem.	2003
10535959	Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function Leong, P, Xu, L, Harrison, SD, Sakanaka, C, Williams, LT	Proc Natl Acad Sci U S A	1999
11818547	Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex Virshup, DM, Yochum, A, Seeling, JM, Hill, V, Gao, ZH	Proc Natl Acad Sci U S A	2002
21285348	Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases Polonio, T, Schulte, G, Bernatik, O, Bryja, V, Konik, P, Ganji, RS, Krejci, P, Cervenka, I, Dijksterhuis, JP	J. Biol. Chem.	2011