CSNK1E and DVL physically interact in vivo and CSNK1E phosphorylates DVL in response to WNT signaling (Peters et al, 1999; Sakanaka et al, 1999; Kishida et al, 2001; Gao et al, 2002; Hino et al, 2003; Klimowski et al, 2006; Bernatik et al, 2011). Phosphorylation by CSNK1E in the PDZ domain of DVL appears to be required for the recruitment of AXIN and the subsequent phosphorylation of LRP6 (Bernatik et al, 2011).
Kishida, M, Kikuchi, A, Asashima, M, Hino, S, Kishida, S, Michiue, T, Fukui, A, Yamamoto, H
Peters, JM, McKay, JP, McKay, RM, Graff, JM
Garcia, BA, Shabanowitz, J, Virshup, DM, Klimowski, LK, Hunt, DF
Kikuchi, A, Asashima, M, Hino, S, Michiue, T
Leong, P, Xu, L, Harrison, SD, Sakanaka, C, Williams, LT
Virshup, DM, Yochum, A, Seeling, JM, Hill, V, Gao, ZH
Polonio, T, Schulte, G, Bernatik, O, Bryja, V, Konik, P, Ganji, RS, Krejci, P, Cervenka, I, Dijksterhuis, JP
protein serine/threonine kinase activity of CSNK1E [cytosol]
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