Reactome | PPP2R2A [cytosol]

PPP2R2A [cytosol]

Stable Identifier

R-HSA-377253

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PP2A-regulatory subunit B55 alpha isoform

Locations in the PathwayBrowser for interactor UniProt:P30154 PPP2R1B

Expand all

External Reference Information

External Reference

UniProt:P63151 PPP2R2A

Gene Names

PPP2R2A

Chain

initiator methionine:, chain:2-447

Reference Genes

BioGPS Gene:5520 PPP2R2A

COSMIC (genes):PPP2R2A PPP2R2A

CTD Gene:5520 PPP2R2A

dbSNP Gene:5520 PPP2R2A

ENSEMBL:ENSG00000221914 PPP2R2A

HGNC:9304 PPP2R2A

KEGG:hsa:5520 PPP2R2A

Monarch:5520 PPP2R2A

NCBI Gene:5520 PPP2R2A

OMIM:604941 PPP2R2A

UCSC:P63151 PPP2R2A

Reference Transcript

Other Identifiers

11756714_a_at

1383_at

202313_PM_at

202313_at

228013_PM_at

228013_at

236492_PM_at

236492_at

3090938

3090939

3090940

3090941

3090942

3090943

3090944

3090956

3090957

3090960

3090961

3090962

3090964

3090965

3090966

3090967

3090968

3090969

3090972

3090973

3090974

3090975

3090977

3090978

3090979

3090980

3090981

3090982

3090983

3090988

3090989

3090990

3090991

3090992

3090993

3090994

3487899

41167_at

46187_at

5520

78278_at

8145440

82421_i_at

82422_r_at

A_14_P123050

A_14_P200963

A_23_P123539

A_24_P346644

GE58038

GO:0000159

GO:0005515

GO:0005654

GO:0005829

GO:0006470

GO:0019888

GO:0043278

GO:0045202

GO:0098772

GO:0098978

HMNXSV003024886

Hs.132822.0.A1_3p_at

Hs.61696.0.A1_3p_at

ILMN_1788961

M64929_at

PH_hs_0028631

TC08002591.hg

g4506018_3p_at

p33838

Participates

as an input of

PPP2R2A binds p-S715-PDE4D5 in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin (Homo sapiens)

as a component of

Other forms of this molecule

PPP2R2A [nucleoplasm]

Inferred To

tws [cytosol] (Drosophila melanogaster)

phr2aB [cytosol] (Dictyostelium discoideum)

CDC55 [cytosol] (Saccharomyces cerevisiae)

pab1 [cytosol] (Schizosaccharomyces pombe)

sur-6 [cytosol] (Caenorhabditis elegans)

ppp2r2a [cytosol] (Xenopus tropicalis)

Ghost homologue of PPP2R2A [cytosol] (Plasmodium falciparum)

PPP2R2A [cytosol] (Bos taurus)

PPP2R2A [cytosol] (Canis familiaris)

PPP2R2A [cytosol] (Gallus gallus)

PPP2R2A [cytosol] (Sus scrofa)

Ppp2r2a [cytosol] (Mus musculus)

Ppp2r2a [cytosol] (Rattus norvegicus)

ppp2r2ab [cytosol] (Danio rerio)

Cross References

RefSeq

NP_002708.1, NP_001171062.1

OpenTargets

ENSG00000221914

ENSEMBL

ENST00000315985, ENST00000380737, ENSP00000370113, ENSP00000325074

HPA

ENSG00000221914-PPP2R2A

ZINC target

P63151

PRO

P63151

Pharos - Targets

P63151

GlyGen

P63151

PDB

8TWE, 8TTB, 8SO0, 3DW8

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.953	20
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.915	12
UniProt:P62714 PPP2CB	4	MeL-PPP2CB [nucleoplasm] (R-HSA-8857799) p-Y307-PPP2CB [cytosol] (R-HSA-8857935) PPP2CB [nucleoplasm] (R-HSA-165991) PPP2CB [cytosol] (R-HSA-165987)	0.886	8
UniProt:P30154 PPP2R1B	2	PPP2R1B [nucleoplasm] (R-HSA-166000) PPP2R1B [cytosol] (R-HSA-165980)	0.727	5
UniProt:Q9BXL8 CDCA4			0.671	6
UniProt:Q66LE6 PPP2R2D	1	PPP2R2D [nucleoplasm] (R-HSA-2160962)	0.671	7
UniProt:Q76MZ3 Ppp2r1a	2	Ppp2r1a [nucleoplasm] (R-MMU-165968) PP2A A subunit [cytosol] (R-MMU-206067)	0.669	3
UniProt:Q96E09 PBIR1			0.643	4
UniProt:Q9NUC0 SRTD4			0.643	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.641	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	16
UniProt:P53355 DAPK1	1	DAPK1 [cytosol] (R-HSA-418262)	0.593	3
UniProt:Q99958 FOXC2	1	FOXC2 [nucleoplasm] (R-HSA-3927898)	0.564	2
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.556	3
UniProt:Q9NZR2 LRP1B			0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q8NE08 Q8NE08			0.556	3
UniProt:Q12950 FOXD4			0.527	4
UniProt:Q8IVT5 KSR1	5	p-S311,Y602 KSR1 [cytosol] (R-HSA-5672656) p-S311,Y602 KSR1 [plasma membrane] (R-HSA-5672659) p-S311 KSR1 [cytosol] (R-HSA-5672652) KSR1 [cytosol] (R-HSA-5672587) p-S311,S406 KSR1 [cytosol] (R-HSA-5672654)	0.527	2
UniProt:Q9BTL4 IER2			0.527	4
UniProt:Q12948 FOXC1	1	FOXC1 [nucleoplasm] (R-HSA-3927815)	0.527	2
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.527	2
UniProt:Q96IG2 FBXL20	1	FBXL20 [cytosol] (R-HSA-8862591)	0.463	4
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.462	2

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