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p-S473-AKT1 [plasma membrane]
Stable Identifier
R-HSA-377265
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
RAC-alpha serine/threonine kinase , RAC-PK-alpha, Protein kinase B, PKB, C-AKT
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
mTORC2 phosphorylates AKT1 on serine-473 (Homo sapiens)
p-S473-AKT1:PIP3 [plasma membrane] (Homo sapiens)
p-S473-AKT1 [plasma membrane] (Homo sapiens)
p-T816-PKN2 phosphorylates AKT1 on serine-308 (Homo sapiens)
p-S473-AKT1:PIP3 [plasma membrane] (Homo sapiens)
p-S473-AKT1 [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 targets host intracellular signalling and regulatory pathways (Homo sapiens)
PDPK1 phosphorylates AKT at T308 (Homo sapiens)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT [plasma membrane] (Homo sapiens)
p-S473-AKT1 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
AKT binds PDPK1 (Homo sapiens)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT [plasma membrane] (Homo sapiens)
p-S473-AKT1 [plasma membrane] (Homo sapiens)
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT [plasma membrane] (Homo sapiens)
p-S473-AKT1 [plasma membrane] (Homo sapiens)
PDPK1 phosphorylates AKT at T308 (Homo sapiens)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT [plasma membrane] (Homo sapiens)
p-S473-AKT1 [plasma membrane] (Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT [plasma membrane] (Homo sapiens)
p-S473-AKT1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
AKT binds PDPK1 (Homo sapiens)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT [plasma membrane] (Homo sapiens)
p-S473-AKT1 [plasma membrane] (Homo sapiens)
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT [plasma membrane] (Homo sapiens)
p-S473-AKT1 [plasma membrane] (Homo sapiens)
PDPK1 phosphorylates AKT at T308 (Homo sapiens)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT [plasma membrane] (Homo sapiens)
p-S473-AKT1 [plasma membrane] (Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT [plasma membrane] (Homo sapiens)
p-S473-AKT1 [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
AKT binds PDPK1 (Homo sapiens)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT [plasma membrane] (Homo sapiens)
p-S473-AKT1 [plasma membrane] (Homo sapiens)
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT [plasma membrane] (Homo sapiens)
p-S473-AKT1 [plasma membrane] (Homo sapiens)
PDPK1 phosphorylates AKT at T308 (Homo sapiens)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT [plasma membrane] (Homo sapiens)
p-S473-AKT1 [plasma membrane] (Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
p-S-AKT:PIP3 [plasma membrane] (Homo sapiens)
p-S-AKT [plasma membrane] (Homo sapiens)
p-S473-AKT1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P31749 AKT1
Gene Names
AKT1, PKB, RAC
Chain
chain:1-480
Reference Genes
BioGPS Gene:207 AKT1
COSMIC (genes):AKT1 AKT1
CTD Gene:207 AKT1
dbSNP Gene:207 AKT1
ENSEMBL:ENSG00000142208 AKT1
ENSEMBL_homo_sapiens_GENE:ENSG00000142208.18 AKT1
HGNC:391 AKT1
KEGG Gene (Homo sapiens):207 AKT1
Monarch:207 AKT1
NCBI Gene:207 AKT1
OMIM:164730 AKT1
UCSC:P31749 AKT1
Reference Transcript
RefSeq:NM_001014431.1 AKT1
RefSeq:NM_005163.2 AKT1
RefSeq:XM_005267401.1 AKT1
RefSeq:NM_001014432.1 AKT1
Other Identifiers
11716087_s_at
11722186_a_at
11722187_a_at
1564_at
16797157
207
207163_PM_s_at
207163_s_at
3581133
3581134
3581135
3581136
3581137
3581138
3581143
3581144
3581145
3581148
3581150
3581152
3581155
3581157
3581159
3581161
3581169
3581174
3581175
3581176
3581177
3581178
3581179
3581180
7981494
A_23_P2960
A_33_P3275235
GE58023
GO:0000166
GO:0000278
GO:0001649
GO:0001893
GO:0001934
GO:0001938
GO:0002042
GO:0002376
GO:0003376
GO:0003824
GO:0004672
GO:0004674
GO:0004712
GO:0005515
GO:0005516
GO:0005524
GO:0005547
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005929
GO:0005938
GO:0005975
GO:0005977
GO:0005978
GO:0005979
GO:0006006
GO:0006091
GO:0006351
GO:0006355
GO:0006399
GO:0006417
GO:0006468
GO:0006469
GO:0006606
GO:0006629
GO:0006809
GO:0006886
GO:0006913
GO:0006914
GO:0006915
GO:0006924
GO:0006954
GO:0006979
GO:0007005
GO:0007155
GO:0007165
GO:0007173
GO:0007186
GO:0007249
GO:0007281
GO:0007399
GO:0008283
GO:0008286
GO:0008289
GO:0008637
GO:0008643
GO:0009408
GO:0009725
GO:0010033
GO:0010467
GO:0010507
GO:0010595
GO:0010628
GO:0010629
GO:0010748
GO:0010761
GO:0010763
GO:0010765
GO:0010907
GO:0010951
GO:0010975
GO:0012501
GO:0015630
GO:0016020
GO:0016071
GO:0016242
GO:0016301
GO:0016310
GO:0016567
GO:0016740
GO:0018105
GO:0018107
GO:0019049
GO:0019221
GO:0019899
GO:0019901
GO:0022414
GO:0022605
GO:0023052
GO:0030027
GO:0030154
GO:0030163
GO:0030235
GO:0030291
GO:0030307
GO:0030334
GO:0031295
GO:0031397
GO:0031641
GO:0031663
GO:0031929
GO:0031982
GO:0031999
GO:0032079
GO:0032091
GO:0032094
GO:0032287
GO:0032436
GO:0032869
GO:0032880
GO:0032991
GO:0033138
GO:0034330
GO:0034405
GO:0034614
GO:0035556
GO:0035655
GO:0035924
GO:0036064
GO:0036211
GO:0036294
GO:0038061
GO:0042593
GO:0042802
GO:0042803
GO:0042981
GO:0043066
GO:0043154
GO:0043161
GO:0043226
GO:0043276
GO:0043325
GO:0043488
GO:0043491
GO:0043536
GO:0044782
GO:0045429
GO:0045600
GO:0045725
GO:0045737
GO:0045746
GO:0045861
GO:0045893
GO:0045944
GO:0046326
GO:0046622
GO:0046777
GO:0046889
GO:0048009
GO:0048266
GO:0048661
GO:0048856
GO:0048870
GO:0050877
GO:0051000
GO:0051091
GO:0051146
GO:0051247
GO:0055085
GO:0060079
GO:0060416
GO:0060644
GO:0060709
GO:0060716
GO:0061024
GO:0070141
GO:0070848
GO:0071276
GO:0071356
GO:0071363
GO:0071364
GO:0071380
GO:0071889
GO:0071901
GO:0072655
GO:0072656
GO:0072659
GO:0090201
GO:0097011
GO:0097194
GO:0098542
GO:0098772
GO:0098794
GO:0098978
GO:0099104
GO:0099175
GO:0106310
GO:0110002
GO:0140052
GO:0140096
GO:0150033
GO:0160049
GO:1900087
GO:1900182
GO:1901653
GO:1901796
GO:1902018
GO:1902176
GO:1903038
GO:1903078
GO:1903721
GO:1904263
GO:1905552
GO:1990090
GO:1990418
GO:2000010
GO:2000074
GO:2000402
GO:2001240
GO:2001243
HMNXSV003045285
ILMN_1748661
ILMN_2388507
ILMN_2410909
M63167_at
PH_hs_0024085
TC14001560.hg
g4885060_3p_a_at
Participates
as a component of
p-S473-AKT1:PIP3 [plasma membrane] (Homo sapiens)
as a member of
p-S-AKT [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-T308,S473-AKT1 E17K [nucleoplasm]
p-T308,S473-AKT1 E17K [cytosol]
AKT1 E17K [cytosol]
p-S473-AKT1 E17K [plasma membrane]
AKT1 E17K [plasma membrane]
p-S473-AKT1 [cytosol]
p-T308,S473-AKT1 [plasma membrane]
p-Y315,Y326-AKT1 [cytosol]
p-T308-AKT1 [cytosol]
AKT1 [cytosol]
AKT1 [plasma membrane]
p-T308,S473-AKT1 [cytosol]
p-T308,S473-AKT1 [nucleoplasm]
Inferred To
phospho-p-S473-AKT1 [plasma membrane]
(Caenorhabditis elegans)
phospho-p-S473-AKT1 [plasma membrane]
(Danio rerio)
phospho-p-S473-AKT1 [plasma membrane]
(Dictyostelium discoideum)
phospho-p-S473-AKT1 [plasma membrane]
(Drosophila melanogaster)
phospho-p-S473-AKT1 [plasma membrane]
(Mus musculus)
phospho-p-S473-AKT1 [plasma membrane]
(Rattus norvegicus)
phospho-p-S473-AKT1 [plasma membrane]
(Saccharomyces cerevisiae)
phospho-p-S473-AKT1 [plasma membrane]
(Schizosaccharomyces pombe)
Homologues of p-S473-AKT1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of p-S473-AKT1 [plasma membrane]
(Dictyostelium discoideum)
Homologues of p-S473-AKT1 [plasma membrane]
(Saccharomyces cerevisiae)
Homologues of p-S473-AKT1 [plasma membrane]
(Schizosaccharomyces pombe)
phospho-AKT1 [plasma membrane]
(Gallus gallus)
Modified Residues
Name
O-phospho-L-serine at 473
Coordinate
473
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_005267458.1
,
NP_005154.2
,
NP_001014432.1
,
NP_001014431.1
ZINC - World Drugs
AKT1_HUMAN
Guide to Pharmacology - Targets
1479
OpenTargets
ENSG00000142208
ZINC - FDA approved
AKT1_HUMAN
ZINC - Substances
AKT1_HUMAN
ZINC - Biogenic
AKT1_HUMAN
ZINC target
P31749
PRO
P31749
PDB
4EKK
,
7APJ
,
1UNQ
,
6HHF
,
1H10
,
1UNR
,
3O96
,
3MV5
,
1UNP
,
7MYX
,
6S9X
,
3CQW
,
6CCY
,
6S9W
,
6NPZ
,
3CQU
,
3OW4
,
3QKM
,
2UZS
,
3QKL
,
4EJN
,
2UZR
,
6HHJ
,
2UVM
,
3QKK
,
3MVH
,
6BUU
,
6HHI
,
7NH5
,
6HHH
,
7NH4
,
4GV1
,
6HHG
,
4EKL
,
3OCB
,
5KCV
ZINC - Investigational
AKT1_HUMAN
ZINC - Metabolites
AKT1_HUMAN
GeneCards
P31749
HPA
ENSG00000142208-AKT1
Ensembl
ENST00000554581
,
ENSP00000270202
,
ENST00000554848
,
ENSP00000497822
,
ENSG00000142208
,
ENST00000683722
,
ENST00000649815
,
ENST00000407796
,
ENSP00000384293
,
ENSP00000451828
,
ENST00000555528
,
ENSP00000507879
,
ENST00000402615
,
ENSP00000451166
,
ENSP00000385326
,
ENST00000349310
,
ENSP00000450688
Pharos - Targets
P31749
Orphanet
20544
ZINC - Predictions - Purchasable
AKT1_HUMAN
HMDB Protein
HMDBP01385
Interactors (74)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P56279 TCL1A
0.83
8
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.807
6
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.779
4
UniProt:O15530 PDPK1
3
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.767
4
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
PPP2CA [cytosol]
(R-HSA-165971)
0.756
4
UniProt:Q5T1C6 THEM4
3
THEM4 [mitochondrial matrix]
(R-HSA-162408)
THEM4 [cytosol]
(R-HSA-6809345)
THEM4 [plasma membrane]
(R-HSA-199437)
0.734
4
UniProt:P42345 MTOR
2
MTOR [nucleoplasm]
(R-HSA-5083674)
MTOR [cytosol]
(R-HSA-165662)
0.731
4
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE
0.724
5
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.708
5
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.706
29
UniProt:O43524 FOXO3
11
p-S215 FOXO3 [nucleoplasm]
(R-HSA-5687010)
p-S215 FOXO3 [cytosol]
(R-HSA-5687014)
FOXO3 [cytosol]
(R-HSA-5687032)
p-S43,S173,S294,S325-FOXO3 [nucleoplasm]
(R-HSA-8870627)
p-S43,S173,S294,S325-FOXO3 [cytosol]
(R-HSA-8870560)
FOXO3(?-673) [mitochondrial matrix]
(R-HSA-9841824)
Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix]
(R-HSA-9841849)
Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm]
(R-HSA-9620514)
p-T32,S253,S315-FOXO3 [cytosol]
(R-HSA-9614413)
p-T32,S253,S315-FOXO3 [nucleoplasm]
(R-HSA-199289)
FOXO3 [nucleoplasm]
(R-HSA-199305)
0.692
3
UniProt:O95999 BCL10
3
K48polyUb-BCL10 [cytosol]
(R-HSA-8939329)
BCL10 [cytosol]
(R-HSA-202447)
p-BCL10 [cytosol]
(R-HSA-202488)
0.69
5
UniProt:Q6GPH4 XAF1
1
XAF1 [cytosol]
(R-HSA-1015680)
0.666
4
UniProt:P31751 AKT2
7
p-T309,S474-AKT2 [plasma membrane]
(R-HSA-202056)
p-T309-AKT2 [cytosol]
(R-HSA-202066)
AKT2 [cytosol]
(R-HSA-49859)
AKT2 [plasma membrane]
(R-HSA-202053)
p-S474-AKT2 [plasma membrane]
(R-HSA-2317312)
p-T309,S474-AKT2 [cytosol]
(R-HSA-202062)
p-T309,S474-AKT2 [nucleoplasm]
(R-HSA-202087)
0.641
3
UniProt:P23443 RPS6KB1
2
RPS6KB1 [cytosol]
(R-HSA-165716)
p-T412-RPS6KB1 [cytosol]
(R-HSA-165714)
0.64
3
UniProt:P53804 TTC3
0.639
4
UniProt:Q86V81 ALYREF
2
ALYREF [nucleoplasm]
(R-HSA-156649)
ALYREF [cytosol]
(R-HSA-158482)
0.639
5
UniProt:Q15047 SETDB1
1
SETDB1 [nucleoplasm]
(R-HSA-417136)
0.639
9
UniProt:P46527 CDKN1B
8
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
CDKN1B [cytosol]
(R-HSA-198622)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
CDKN1B [nucleoplasm]
(R-HSA-182563)
0.63
3
UniProt:Q13043 STK4
4
STK4(1-487) [cytosol]
(R-HSA-201627)
p-T183-STK4(1-326) [cytosol]
(R-HSA-2028682)
p-T183-STK4(1-487) [cytosol]
(R-HSA-2028258)
STK4(327-487) [cytosol]
(R-HSA-2028668)
0.619
13
UniProt:P04150 NR3C1
3
SUMO1-K277,K293-NR3C1 [nucleoplasm]
(R-HSA-4341106)
NR3C1 [cytosol]
(R-HSA-5618118)
NR3C1 [nucleoplasm]
(R-HSA-879837)
0.611
5
UniProt:P26358 DNMT1
2
monoSUMO1-K-DNMT1 [nucleoplasm]
(R-HSA-4655353)
DNMT1 [nucleoplasm]
(R-HSA-212181)
0.611
6
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.609
3
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.602
5
UniProt:P19174 PLCG1
6
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
0.602
9
UniProt:O60437 PPL
2
PPL [cytosol]
(R-HSA-6810850)
PPL [cornified envelope]
(R-HSA-8847709)
0.573
2
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.571
4
UniProt:Q12778 FOXO1
5
p-S218-FOXO1 [nucleoplasm]
(R-HSA-5692651)
Ac-K245,K248,K265-FOXO1 [nucleoplasm]
(R-HSA-9626942)
FOXO1 [nucleoplasm]
(R-HSA-199300)
p-T24,S256,S319-FOXO1 [nucleoplasm]
(R-HSA-199306)
p-T24,S256,S319-FOXO1 [cytosol]
(R-HSA-211158)
0.571
2
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
3
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.558
6
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.558
2
UniProt:Q9UNE7-1 STUB1
0.558
5
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.556
3
UniProt:Q96D03 DDT4L
0.556
3
UniProt:Q9H0C5 BTBD1
1
BTBD1 [cytosol]
(R-HSA-8851650)
0.556
3
UniProt:Q15438 CYTH1
2
CYTH1 [cytosol]
(R-HSA-8847826)
CYTH1 [Golgi membrane]
(R-HSA-8847825)
0.556
3
UniProt:Q8WUY3 PRUN2
0.556
3
UniProt:Q96LI6-3 Q96LI63
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q8TAP6 CEP76
1
CEP76 [cytosol]
(R-HSA-380281)
0.556
3
UniProt:P54253 ATX1
0.556
6
IntAct:EBI-25830852 RZPDO839G03145
0.556
3
UniProt:P17028 ZNF24
0.556
3
UniProt:Q9UQM7 CAMK2A
6
p-T286-CAMK2A [plasma membrane]
(R-HSA-432796)
p-T286-CAMK2A [nucleoplasm]
(R-HSA-444797)
p-T286-CAMK2A [endocytic vesicle membrane]
(R-HSA-416999)
p-T286,T305,T306-CAMK2A [cytosol]
(R-HSA-4332334)
CAMK2A [cytosol]
(R-HSA-4332329)
p-T286-CAMK2A [cytosol]
(R-HSA-445368)
0.556
3
UniProt:P10599 TXN
4
2xHC-TXN [nucleoplasm]
(R-HSA-9617733)
TXN [nucleoplasm]
(R-HSA-9617732)
2xHC-TXN [cytosol]
(R-HSA-73668)
TXN [cytosol]
(R-HSA-66000)
0.556
3
UniProt:Q14696 MESD
0.556
3
UniProt:P17612 PRKACA
4
PRKACA [mitochondrial matrix]
(R-HSA-9838291)
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [cytosol]
(R-HSA-57844)
0.556
3
UniProt:P22466 GAL
1
GAL [extracellular region]
(R-HSA-389038)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P05771 PRKCB
5
PRKCB [plasma membrane]
(R-HSA-156467)
PRKCB [cytosol]
(R-HSA-58198)
p-T500-PRKCB [cytosol]
(R-HSA-5218728)
p-T500,T642,S661-PRKCB [cytosol]
(R-HSA-5218706)
p-T500,T642,S661-PRKCB [nucleoplasm]
(R-HSA-5223294)
0.547
2
UniProt:P49327 FASN
3
FASN [cytosol]
(R-HSA-199233)
decanoyl-FASN [cytosol]
(R-HSA-5655935)
FASN [cytosol]
(R-HSA-54659)
0.547
2
UniProt:P30153 PPP2R1A
2
PPP2R1A [nucleoplasm]
(R-HSA-165968)
PPP2R1A [cytosol]
(R-HSA-165982)
0.544
2
UniProt:Q05513 PRKCZ
5
p-T410,T563-PRKCZ [cytosol]
(R-HSA-5218698)
PRKCZ [cytosol]
(R-HSA-58218)
PRKCZ [cell junction]
(R-HSA-2134483)
p-T410-PRKCZ [cytosol]
(R-HSA-437181)
pS, p-T410-PRKCZ [cytosol]
(R-HSA-9632824)
0.544
2
UniProt:Q9BZQ8 NIBA1
0.544
2
UniProt:Q92547 TOPBP1
1
TOPBP1 [nucleoplasm]
(R-HSA-5684878)
0.544
2
UniProt:Q14643 ITPR1
2
ITPR1 [platelet dense tubular network membrane]
(R-HSA-3325593)
ITPR1 [endoplasmic reticulum membrane]
(R-HSA-3006433)
0.536
2
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.536
2
UniProt:P24468 NR2F2
1
NR2F2 [nucleoplasm]
(R-HSA-1183002)
0.527
2
UniProt:P38646 HSPA9
6
HSPA9 [mitochondrial matrix]
(R-HSA-8878802)
HSPA9 [mitochondrial inner membrane]
(R-HSA-1252206)
HSPA9(1-679) [cytosol]
(R-HSA-1267964)
HSPA9(1-679) [mitochondrial intermembrane space]
(R-HSA-1267968)
HSPA9 [nucleoplasm]
(R-HSA-5252128)
HSPA9 [cytosol]
(R-HSA-5251993)
0.527
3
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.527
3
UniProt:Q96S96 PEBP4
0.524
2
UniProt:P29067
3
Arrb2 [endocytic vesicle membrane]
(R-RNO-9910881)
Arrb2 [cytosol]
(R-RNO-6783000)
Arrb2 [cytosol]
(R-RNO-416464)
0.524
2
UniProt:Q83730 MT5
0.524
3
UniProt:P20248 CCNA2
3
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [cytosol]
(R-HSA-157444)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.524
2
UniProt:Q9UKG1 APPL1
1
APPL1 [endosome membrane]
(R-HSA-373630)
0.519
2
UniProt:Q9NYB0 TERF2IP
1
TERF2IP [nucleoplasm]
(R-HSA-174873)
0.508
2
UniProt:Q8IXJ9 ASXL1
1
ASXL1 [nucleoplasm]
(R-HSA-5689645)
0.508
2
IntAct:EBI-4399559 UBIQ
0.499
2
UniProt:Q92793 CREBBP
4
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
CREBBP [cytosol]
(R-HSA-9756493)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.499
3
UniProt:P10636 MAPT
3
MAPT(422-758) [cytosol]
(R-HSA-350642)
MAPT(2-421) [cytosol]
(R-HSA-350628)
MAPT [cytosol]
(R-HSA-201574)
0.499
2
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.483
3
UniProt:P11021 HSPA5
6
HSPA5 [extracellular region]
(R-HSA-351322)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
0.471
2
UniProt:P10276 RARA
3
SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]
(R-HSA-5334830)
polySUMO2-K166,K171,K399-RARA [nucleoplasm]
(R-HSA-4341042)
RARA [nucleoplasm]
(R-HSA-446164)
0.463
2
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