Reactome | EIF3M [cytosol]

EIF3M [cytosol]

Stable Identifier

R-HSA-377448

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF3m

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q7L2H7 EIF3M

Gene Names

EIF3M, HFLB5, PCID1, GA17, PNAS-125

Chain

initiator methionine:, chain:2-374

Reference Genes

BioGPS Gene:10480 EIF3M

COSMIC (genes):EIF3M EIF3M

CTD Gene:10480 EIF3M

dbSNP Gene:10480 EIF3M

ENSEMBL:ENSG00000149100 EIF3M

HGNC:24460 EIF3M

KEGG:hsa:10480 EIF3M

Monarch:10480 EIF3M

NCBI Gene:10480 EIF3M

OMIM:609641 EIF3M

UCSC:Q7L2H7 EIF3M

Reference Transcript

Other Identifiers

10480

11729152_a_at

11752911_a_at

11752912_x_at

11763816_a_at

16723294

202231_PM_at

202231_at

202232_PM_s_at

202232_s_at

215190_PM_at

215190_at

239848_PM_at

239848_at

3325681

3325682

3325683

3325684

3325689

3325690

3325691

3325693

3325694

3325695

3325696

3325697

3325700

3325701

3325702

3325703

3325704

3325705

3325707

3325708

3325710

3325711

3325712

3325713

3325714

3325715

3325716

3325717

3325718

3325719

3325720

3325721

3325723

3325724

3325725

35814_at

3982929

66366_at

73112_at

7939137

90399_r_at

A_14_P113173

A_23_P150446

A_24_P138361

A_32_P68076

GE54591

GE549804

GE790701

GE86341

GO:0001732

GO:0002183

GO:0003743

GO:0005515

GO:0005737

GO:0005829

GO:0005852

GO:0006412

GO:0006413

GO:0016282

GO:0031369

GO:0032991

GO:0033290

GO:0045182

GO:0065003

GO:0071541

HMNXSV003029910

Hs.120054.0.A1_3p_at

Hs.274553.0.S1_3p_at

ILMN_2192693

ILMN_2192694

PH_hs_0022126

PH_hs_0036714

TC11000309.hg

TC11002622.hg

g5453653_3p_at

Participates

as a component of

eIF3 subunits complex [cytosol] (Homo sapiens)

Inferred To

Eif3m [cytosol] (Mus musculus)

Eif3m [cytosol] (Rattus norvegicus)

Ghost homologue of EIF3M [cytosol] (Saccharomyces cerevisiae)

eIF3m [cytosol] (Drosophila melanogaster)

eif3m [cytosol] (Danio rerio)

eif3m [cytosol] (Dictyostelium discoideum)

eif3m [cytosol] (Schizosaccharomyces pombe)

eif3m [cytosol] (Xenopus tropicalis)

Homologues of EIF3M [cytosol] (Bos taurus)

EIF3M [cytosol] (Bos taurus)

EIF3M [cytosol] (Canis familiaris)

EIF3M [cytosol] (Gallus gallus)

EIF3M [cytosol] (Plasmodium falciparum)

EIF3M [cytosol] (Sus scrofa)

cif-1 [cytosol] (Caenorhabditis elegans)

Cross References

OpenTargets

ENSG00000149100

ENSEMBL

ENST00000524896, ENST00000531120, ENSP00000436787, ENSP00000436049, ENSG00000149100

HPA

ENSG00000149100-EIF3M

GeneCards

EIF3M

PRO

Q7L2H7

Pharos - Targets

Q7L2H7

GlyGen

Q7L2H7

PDB

8RG0, 7A09, 3J8B, 8OZ0, 8PJ1, 3J8C, 9BLN, 8PJ3, 8PJ5, 6ZMW, 8PJ2, 6FEC, 8PJ4, 6ZON, 8XXN, 8PJ6, 6ZVJ, 8PPL, 6YBD, 7QP7, 7QP6, 6ZP4

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [secretory granule lumen] (R-HSA-6800934)	0.643	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	4