Autophosphorylation of SRC

Stable Identifier
R-HSA-377640
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Autophosphorylation of SRC
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Clustering of Integrin alphaIIb beta3 complexes results in the trans auto-phosphorylation of SRC tyrosine residue 419 (often referred to as 418 in the literature, as the initiating methionine is cleaved in the mature peptide) in SRC's kinase activation loop.
Literature References
PubMed ID Title Journal Year
16005629 Integrins and Src: dynamic duo of adhesion signaling

Shattil, SJ

Trends Cell Biol 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of SRC-1 [cytosol]

Physical Entity
SRC-1 [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Autophosphorylation of SRC (Bos taurus)
Autophosphorylation of SRC (Caenorhabditis elegans)
Autophosphorylation of SRC (Canis familiaris)
Autophosphorylation of SRC (Danio rerio)
Autophosphorylation of SRC (Drosophila melanogaster)
Autophosphorylation of SRC (Gallus gallus)
Autophosphorylation of SRC (Mus musculus)
Autophosphorylation of SRC (Rattus norvegicus)
Autophosphorylation of SRC (Sus scrofa)
Authored
Garapati, P V  (2008-06-16)
Reviewed
Shattil, SJ  (2008-09-16)
Created
Garapati, P V  (2008-09-15)
Cite Us!