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Release of CSK from SRC
Stable Identifier
R-HSA-377644
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Release of CSK from SRC (Homo sapiens)
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Release of CSK from SRC (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CSK bound to integrin alphaIIb beta3 negatively regulates SRC by phosphorylating the Tyr-530. Platelet adhesion to fibrinogen causes the disassociation of CSK from alphaIIb beta3 complex.
Literature References
PubMed ID
Title
Journal
Year
1722201
CSK: a protein-tyrosine kinase involved in regulation of src family kinases
Nakagawa, H
,
Yamamoto, T
,
Okada, M
,
Yamanashi, Y
,
Nada, S
J Biol Chem
1991
16005629
Integrins and Src: dynamic duo of adhesion signaling
Shattil, SJ
Trends Cell Biol
2005
Participants
Input
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane]
(Homo sapiens)
Output
x 2
CSK [cytosol]
(Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane]
(Homo sapiens)
Participates
as an event of
Integrin signaling (Homo sapiens)
Orthologous Events
Release of CSK from SRC (Bos taurus)
Release of CSK from SRC (Caenorhabditis elegans)
Release of CSK from SRC (Canis familiaris)
Release of CSK from SRC (Danio rerio)
Release of CSK from SRC (Drosophila melanogaster)
Release of CSK from SRC (Gallus gallus)
Release of CSK from SRC (Mus musculus)
Release of CSK from SRC (Rattus norvegicus)
Release of CSK from SRC (Sus scrofa)
Authored
Garapati, P V (2008-06-16)
Reviewed
Shattil, SJ (2008-09-16)
Created
Garapati, P V (2008-09-15)
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