SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)

Stable Identifier
R-HSA-3777112
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial intermembrane space
ReviewStatus
5/5
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SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)
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A portion of SOD1 is located in the mitochondrial intermembrane space (IMS) where it catalyzes the formation of oxygen (O2) and hydrogen peroxide (H2O2) from superoxide (O2.-) (He et al. 2011, Higgins et al. 2002, inferred from rat in Okado-Matsumoto and Fridovich 2001).
Literature References
PubMed ID Title Journal Year
11507097 Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria

Fridovich, I, Okado-Matsumoto, A

J. Biol. Chem. 2001
11886899 Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS

Xu, Z, Ding, H, Higgins, CM, Jung, C

J. Neurosci. 2002
21393238 Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation

Spitz, DR, Ryan, AJ, McCormick, ML, Murthy, S, He, C, Carter, AB

J. Biol. Chem. 2011
Participants
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Output
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as an event of
Catalyst Activity

superoxide dismutase activity of SOD1 dimer [mitochondrial intermembrane space]

Physical Entity
SOD1 dimer [mitochondrial intermembrane space] (Homo sapiens)
Activity
superoxide dismutase activity (GO:0004784)
Orthologous Events
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Bos taurus)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Caenorhabditis elegans)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Canis familiaris)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Danio rerio)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Dictyostelium discoideum)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Drosophila melanogaster)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Gallus gallus)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Mus musculus)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Rattus norvegicus)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Saccharomyces cerevisiae)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Schizosaccharomyces pombe)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Sus scrofa)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Xenopus tropicalis)
Cross References
Rhea
Authored
May, B  (2013-06-26)
Reviewed
Kavdia, M  (2013-11-01)
Created
May, B  (2013-06-26)
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