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K48polyUb-PPP1R3C [cytosol]
Stable Identifier
R-HSA-3781005
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
K48polyUb-Protein phosphatase 1 regulatory subunit 3C, K48polyUb-PTG, K48polyUb-Protein targeting to glycogen, K48polyUb-PPP1R5
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycogen metabolism (Homo sapiens)
Glycogen synthesis (Homo sapiens)
NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2 (Homo sapiens)
K48polyUb-PPP1R3C [cytosol] (Homo sapiens)
NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1 (Homo sapiens)
K48polyUb-PPP1R3C [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
18070875
Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG)
Gentry, MS
,
Worby, CA
,
Dixon, JE
J. Biol. Chem.
2008
External Reference Information
External Reference
UniProt:Q9UQK1 PPP1R3C
Gene Names
PPP1R3C, PPP1R5
Chain
chain:1-317
Reference Genes
BioGPS Gene:5507 PPP1R3C
COSMIC (genes):PPP1R3C PPP1R3C
CTD Gene:5507 PPP1R3C
dbSNP Gene:5507 PPP1R3C
ENSEMBL:ENSG00000119938 PPP1R3C
HGNC:9293 PPP1R3C
KEGG:hsa:5507 PPP1R3C
Monarch:5507 PPP1R3C
NCBI Gene:5507 PPP1R3C
OMIM:602999 PPP1R3C
UCSC:Q9UQK1 PPP1R3C
Reference Transcript
RefSeq:NM_005398.6 PPP1R3C
Other Identifiers
11717575_at
11749593_a_at
16716507
204284_PM_at
204284_at
3300128
3300129
3300130
3300131
3300132
3300134
39364_s_at
39365_i_at
39366_at
5507
7934997
A_23_P35414
GE79462
GO:0000164
GO:0003824
GO:0004722
GO:0005515
GO:0005829
GO:0005975
GO:0005977
GO:0005978
GO:0005979
GO:0006091
GO:0008157
GO:0016787
GO:0019903
GO:0060090
GO:0140096
GO:2001069
HMNXSV003043025
Hs.303090.0.S2_3p_at
ILMN_1736670
PH_hs_0015649
TC10001522.hg
Participates
as an output of
NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2 (Homo sapiens)
NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1 (Homo sapiens)
Other forms of this molecule
PPP1R3C [cytosol]
Inferred To
ppp1r3cb [cytosol]
(Danio rerio)
Gbs-70E [cytosol]
(Drosophila melanogaster)
GIP2 [cytosol]
(Saccharomyces cerevisiae)
Homologues of K48polyUb-PPP1R3C [cytosol]
(Saccharomyces cerevisiae)
PPP1R3C [cytosol]
(Bos taurus)
PPP1R3C [cytosol]
(Canis familiaris)
Ppp1r3c [cytosol]
(Mus musculus)
Ppp1r3c [cytosol]
(Rattus norvegicus)
GAC1 [cytosol]
(Saccharomyces cerevisiae)
PIG2 [cytosol]
(Saccharomyces cerevisiae)
K48polyUb-PPP1R3C [cytosol]
(Caenorhabditis elegans)
K48polyUb-PPP1R3C [cytosol]
(Gallus gallus)
K48polyUb-PPP1R3C [cytosol]
(Sus scrofa)
PIG1 [cytosol]
(Saccharomyces cerevisiae)
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
ENSEMBL
ENST00000238994
,
ENSP00000238994
OpenTargets
ENSG00000119938
HPA
ENSG00000119938-PPP1R3C
PRO
Q9UQK1
Pharos - Targets
Q9UQK1
HMDB Protein
HMDBP10678
PDB
7QM2
,
7QF7
,
7QFA
,
7QFB
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62140 PPP1CB
4
PPP1CB [cytosol]
(R-HSA-163405)
PPP1CB P49R [cytosol]
(R-HSA-9660547)
PPP1CB A56P [cytosol]
(R-HSA-9660543)
PPP1CB [nucleoplasm]
(R-HSA-62003)
0.782
9
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.743
5
UniProt:P13807 GYS1
3
p-S-GYS1 [cytosol]
(R-HSA-71570)
GYS1 [cytosol]
(R-HSA-71565)
GYS1 R462* [cytosol]
(R-HSA-3828056)
0.669
3
UniProt:P36873 PPP1CC
1
PPP1CC [cytosol]
(R-HSA-163443)
0.666
4
UniProt:O95278 EPM2A
5
EPM2A F84L [cytosol]
(R-HSA-3791363)
EPM2A T194I [cytosol]
(R-HSA-3791361)
EPM2A P301L [cytosol]
(R-HSA-3791357)
K48polyUb-EPM2A [cytosol]
(R-HSA-3781004)
EPM2A [cytosol]
(R-HSA-3777103)
0.567
5
UniProt:Q17RB8 LONRF1
1
LONRF1 [cytosol]
(R-HSA-8850905)
0.556
3
UniProt:Q9BS40 LXN
0.556
3
UniProt:O95685 PPR3D
0.527
2
UniProt:Q9GZZ8 LACRT
0.527
2
UniProt:O95210 STBD1
3
STBD1 [tertiary granule membrane]
(R-HSA-6801484)
STBD1 [plasma membrane]
(R-HSA-6801561)
STBD1 [ficolin-1-rich granule membrane]
(R-HSA-6801519)
0.527
2
UniProt:Q9NRN7 AASDHPPT
1
AASDHPPT [cytosol]
(R-HSA-199235)
0.527
2
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