Reactome | GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1

GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1

Stable Identifier

R-HSA-3781024

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1

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Glycogen synthase 1 (GYS1) catalyzes the incorporation of phosphoglucose into the glycogen-GYG1 molecules with which it is associated in a cytosolic glycogen granule. This reaction occurs at a low rate, yielding approximately one molecule of glucose phosphorylated at its C2, C3, or C6 positions incorporated into a growing glycogen polymer per ten thousand glucose molecules incorporated (DePaoli-Roach et al. 2015; Irimia et al. 2015; Nitschke et al. 2013; Tagliabracci et al. 2011). The function of these small amounts of phosphoglucose in normal glycogen remains to be established.

Literature References

PubMed ID	Title	Journal	Year
25416783	Glycogen phosphomonoester distribution in mouse models of the progressive myoclonic epilepsy, Lafora disease Ishihara, M, Segvich, DM, Heiss, C, Roach, PJ, Contreras, CJ, Azadi, P, DePaoli-Roach, AA	J. Biol. Chem.	2015
23663739	Hyperphosphorylation of glucosyl C6 carbons and altered structure of glycogen in the neurodegenerative epilepsy Lafora disease Zhao, X, Schmieder, P, Wang, P, Wang, T, Awrey, DE, Girard, JM, Heydenreich, M, Nitschke, F, Kleinpeter, E, Steup, M, Turnbull, J, Minassian, BA, Israelian, J	Cell Metab.	2013
21356517	Phosphate incorporation during glycogen synthesis and Lafora disease Ishihara, M, Hurley, TD, Glushka, J, Heiss, C, Karthik, C, Roach, PJ, Contreras, CJ, Tagliabracci, VS, DePaoli-Roach, AA, Azadi, P	Cell Metab.	2011
26216881	Muscle Glycogen Remodeling and Glycogen Phosphate Metabolism following Exhaustive Exercise of Wild Type and Laforin Knockout Mice Segvich, DM, Meyer, CM, Roach, PJ, Irimia, JM, Tagliabracci, VS, DePaoli-Roach, AA	J. Biol. Chem.	2015