Reactome | ARID3A [nucleoplasm]

ARID3A [nucleoplasm]

Stable Identifier

R-HSA-3782552

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

AT-rich interactive domain-containing protein 3A, ARI3A_HUMAN, DRIL1, DRX, E2FBP1, DRIL3

Locations in the PathwayBrowser for interactor UniProt:Q06187 BTK

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
        
        TP53 stimulates ARID3A gene expression (Homo sapiens)
        
        ARID3A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99856 ARID3A

Gene Names

ARID3A, DRIL1, DRIL3, DRX, E2FBP1

Chain

chain:1-593

Reference Genes

BioGPS Gene:1820 ARID3A

COSMIC (genes):ARID3A ARID3A

CTD Gene:1820 ARID3A

dbSNP Gene:1820 ARID3A

ENSEMBL:ENSG00000116017 ARID3A

ENSEMBL_homo_sapiens_GENE:ENSG00000116017.11 ARID3A

HGNC:3031 ARID3A

KEGG Gene (Homo sapiens):1820 ARID3A

Monarch:1820 ARID3A

NCBI Gene:1820 ARID3A

OMIM:603265 ARID3A

UCSC:Q99856 ARID3A

Reference Transcript

Other Identifiers

11730399_at

16856315

1820

205865_PM_at

205865_at

228008_PM_at

228008_at

35913_at

3814949

3814950

3814951

3814952

3815279

3815280

3815281

3815282

3815283

3815284

3815285

3815286

3815287

3815288

3815293

3815294

3815295

3815296

3815299

3815300

8024078

89080_at

A_23_P16516

A_24_P42495

A_32_P34522

A_33_P3272921

GE62710

GE745126

GO:0003677

GO:0003682

GO:0003712

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0042802

GO:0043226

GO:0045121

GO:0045944

GO:0140110

HMNXSV003044215

Hs.144583.0.A1_3p_at

ILMN_1670130

PH_hs_0008555

PH_hs_0025639

TC19000023.hg

U88047_at

g4885192_3p_at

Participates

as an output of

TP53 stimulates ARID3A gene expression (Homo sapiens)

Cross References

RefSeq

XP_005259570.1, XP_016881934.1, NP_005215.1, XP_005259571.1

OpenTargets

ENSG00000116017

HPA

ENSG00000116017-ARID3A

GeneCards

Q99856

Ensembl

ENSG00000116017, ENST00000263620, ENSP00000263620

PRO

Q99856

Pharos - Targets

Q99856

PDB

4LJX, 2KK0

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q06187 BTK	6	p-Y223,Y551-BTK [cytosol] (R-HSA-2424454) Active BTK [cytosol] (R-HSA-8964323) p-Y551-BTK [cytosol] (R-HSA-2685603) BTK [cytosol] (R-HSA-197948) p-Y551-BTK [plasma membrane] (R-HSA-9606165) p-Y223,Y551-BTK [plasma membrane] (R-HSA-984807)	0.558	3
UniProt:P23025 XPA	1	XPA [nucleoplasm] (R-HSA-67437)	0.556	3
UniProt:O60220 TIMM8A	2	TIMM8A [mitochondrial intermembrane space] (R-HSA-1307780) 4xHC-TIMM8A [mitochondrial intermembrane space] (R-HSA-1252065)	0.556	3
UniProt:Q15014 MORF4L2	1	MORF4L2 [nucleoplasm] (R-HSA-3322945)	0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:X5D778 X5D778			0.556	3
UniProt:O15479 MAGB2			0.556	3
UniProt:Q6BDI9 REP15			0.556	3
UniProt:Q5I0X7 TTC32			0.556	3
UniProt:O15481 MAGB4			0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	1	NOTCH2NLA [extracellular region] (R-HSA-9908935)	0.556	3
UniProt:Q9UBU8-2 MORF4L1			0.556	3
UniProt:A6NKF2 ARI3C			0.527	2
UniProt:O95714 HERC2	5	HERC2 [nucleoplasm] (R-HSA-4551680) p-T4827-HERC2 [nucleoplasm] (R-HSA-5682601) p-T4827,SUMO1-HERC2 [nucleoplasm] (R-HSA-5682615) HERC2 [cytosol] (R-HSA-975975) monoSUMO1-HERC2 [nucleoplasm] (R-HSA-4551758)	0.527	2
UniProt:Q8IZ13 F200C			0.527	2
UniProt:Q6UWW0 LCN15	1	LCN15 [extracellular region] (R-HSA-5216200)	0.527	2
UniProt:Q8IVW6 ARI3B			0.527	2
UniProt:Q12952 FOXL1			0.483	2
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.483	2
UniProt:P01871 IGHM	1	IGHM [plasma membrane] (R-HSA-983620)	0.462	2