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PLA2G4A [cytosol]
Stable Identifier
R-HSA-378502
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
cPLA2, Cytosolic phospholipase A2, PA24A_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Signal amplification (Homo sapiens)
ADP signalling through P2Y purinoceptor 1 (Homo sapiens)
Phosphorylation of cPLA2 by MAPK p38 alpha (Homo sapiens)
PLA2G4A [cytosol] (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet sensitization by LDL (Homo sapiens)
Phosphorylation of cPLA2 by MAPK p38 alpha (Homo sapiens)
PLA2G4A [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
Glycerophospholipid biosynthesis (Homo sapiens)
Acyl chain remodelling of PC (Homo sapiens)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Homo sapiens)
PLA2(7) [cytosol] (Homo sapiens)
PLA2G4A:Ca2+ [cytosol] (Homo sapiens)
PLA2G4A [cytosol] (Homo sapiens)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Homo sapiens)
PLA2(5) [cytosol] (Homo sapiens)
PLA2G4A:Ca2+ [cytosol] (Homo sapiens)
PLA2G4A [cytosol] (Homo sapiens)
Acyl chain remodelling of PE (Homo sapiens)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Homo sapiens)
PLA2(2) [cytosol] (Homo sapiens)
PLA2G4A:Ca2+ [cytosol] (Homo sapiens)
PLA2G4A [cytosol] (Homo sapiens)
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Homo sapiens)
PLA2(4) [cytosol] (Homo sapiens)
PLA2G4A:Ca2+ [cytosol] (Homo sapiens)
PLA2G4A [cytosol] (Homo sapiens)
Acyl chain remodelling of PG (Homo sapiens)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Homo sapiens)
PLA2(1) [cytosol] (Homo sapiens)
PLA2G4A:Ca2+ [cytosol] (Homo sapiens)
PLA2G4A [cytosol] (Homo sapiens)
Acyl chain remodelling of PI (Homo sapiens)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Homo sapiens)
PLA2(11) [cytosol] (Homo sapiens)
PLA2G4A:Ca2+ [cytosol] (Homo sapiens)
PLA2G4A [cytosol] (Homo sapiens)
Acyl chain remodelling of PS (Homo sapiens)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Homo sapiens)
PLA2(9) [cytosol] (Homo sapiens)
PLA2G4A:Ca2+ [cytosol] (Homo sapiens)
PLA2G4A [cytosol] (Homo sapiens)
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Homo sapiens)
PLA2(10) [cytosol] (Homo sapiens)
PLA2G4A:Ca2+ [cytosol] (Homo sapiens)
PLA2G4A [cytosol] (Homo sapiens)
Hydrolysis of LPC (Homo sapiens)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Homo sapiens)
PLA2(8) [cytosol] (Homo sapiens)
PLA2G4A:Ca2+ [cytosol] (Homo sapiens)
PLA2G4A [cytosol] (Homo sapiens)
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Homo sapiens)
PLA2(8) [cytosol] (Homo sapiens)
PLA2G4A:Ca2+ [cytosol] (Homo sapiens)
PLA2G4A [cytosol] (Homo sapiens)
Synthesis of PA (Homo sapiens)
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Homo sapiens)
PLA2(1) [cytosol] (Homo sapiens)
PLA2G4A:Ca2+ [cytosol] (Homo sapiens)
PLA2G4A [cytosol] (Homo sapiens)
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Homo sapiens)
PLA2(1) [cytosol] (Homo sapiens)
PLA2G4A:Ca2+ [cytosol] (Homo sapiens)
PLA2G4A [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-independent Golgi-to-ER retrograde traffic (Homo sapiens)
PLA2s hydrolyze phospholipids at the Golgi membrane (Homo sapiens)
cPLA2s [cytosol] (Homo sapiens)
PLA2G4A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P47712 PLA2G4A
Gene Names
PLA2G4A, CPLA2, PLA2G4
Chain
chain:1-749
Reference Genes
BioGPS Gene:5321 PLA2G4A
COSMIC (genes):PLA2G4A PLA2G4A
CTD Gene:5321 PLA2G4A
dbSNP Gene:5321 PLA2G4A
ENSEMBL:ENSG00000116711 PLA2G4A
HGNC:9035 PLA2G4A
KEGG:hsa:5321 PLA2G4A
Monarch:5321 PLA2G4A
NCBI Gene:5321 PLA2G4A
OMIM:600522 PLA2G4A
UCSC:P47712 PLA2G4A
Reference Transcript
RefSeq:NM_001311193.1 PLA2G4A
RefSeq:NM_024420.2 PLA2G4A
RefSeq:XM_011509642.2 PLA2G4A
Other Identifiers
11727754_a_at
16675197
210145_PM_at
210145_at
2372212
2372219
2372220
2372222
2372224
2372225
2372226
2372227
2372231
2372234
2372235
2372236
2372237
2372240
2372242
2372243
2372245
2372246
2372248
2372249
2372251
35938_at
5321
7908351
A_14_P107053
A_14_P112455
A_14_P121124
A_14_P134547
A_23_P11685
GE62936
GO:0000139
GO:0001516
GO:0002827
GO:0003824
GO:0004620
GO:0004622
GO:0004623
GO:0005509
GO:0005544
GO:0005634
GO:0005635
GO:0005737
GO:0005743
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0005975
GO:0006071
GO:0006629
GO:0006640
GO:0006650
GO:0006663
GO:0006690
GO:0008289
GO:0008374
GO:0009395
GO:0010314
GO:0010572
GO:0016020
GO:0016740
GO:0016787
GO:0019369
GO:0019370
GO:0032266
GO:0032308
GO:0034478
GO:0034638
GO:0036151
GO:0042127
GO:0043032
GO:0043226
GO:0043231
GO:0046456
GO:0046475
GO:0046872
GO:0047498
GO:0047499
GO:0050482
GO:0051649
GO:0052689
GO:0070273
GO:0071236
GO:1902387
HMNXSV003024546
ILMN_1803561
M68874_at
PH_hs_0012271
TC01001607.hg
g190003_3p_at
Participates
as a member of
cPLA2s [cytosol] (Homo sapiens)
as an input of
Phosphorylation of cPLA2 by MAPK p38 alpha (Homo sapiens)
as a component of
PLA2G4A:Ca2+ [cytosol] (Homo sapiens)
Other forms of this molecule
PLA2G4A [endoplasmic reticulum membrane]
p-S505,S727-PLA2G4A [endoplasmic reticulum membrane]
PLA2G4A [mitochondrial inner membrane]
Inferred To
PLB1 [cytosol]
(Saccharomyces cerevisiae)
PLA2G4A [cytosol]
(Bos taurus)
PLA2G4A [cytosol]
(Canis familiaris)
PLA2G4A [cytosol]
(Danio rerio)
PLA2G4A [cytosol]
(Gallus gallus)
PLA2G4A [cytosol]
(Mus musculus)
PLA2G4A [cytosol]
(Rattus norvegicus)
PLA2G4A [cytosol]
(Schizosaccharomyces pombe)
PLA2G4A [cytosol]
(Sus scrofa)
PLA2G4A [cytosol]
(Xenopus tropicalis)
SPO1 [cytosol]
(Saccharomyces cerevisiae)
plb1 [cytosol]
(Schizosaccharomyces pombe)
PLB3 [cytosol]
(Saccharomyces cerevisiae)
Homologues of PLA2G4A [cytosol]
(Saccharomyces cerevisiae)
Homologues of PLA2G4A [cytosol]
(Schizosaccharomyces pombe)
PLB2 [cytosol]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_077734.1
,
NP_001298122.1
,
XP_011507944.1
Guide to Pharmacology - Targets
1424
ENSEMBL
ENST00000367466
,
ENSP00000356436
OpenTargets
ENSG00000116711
ZINC - Substances
PA24A_HUMAN
ZINC target
P47712
PRO
P47712
PDB
1BCI
,
1CJY
,
1RLW
IntEnz
3.1.1.5
HPA
ENSG00000116711-PLA2G4A
Pharos - Targets
P47712
Orphanet
PLA2G4A
ZINC - Predictions - Purchasable
PA24A_HUMAN
HMDB Protein
HMDBP00060
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
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