Reactome | CGA and CGB3 bind to form Human chorionic gonadotropin (hCG)

CGA and CGB3 bind to form Human chorionic gonadotropin (hCG)

Stable Identifier

R-HSA-378978

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

CGA and CGB3 bind to form Human chorionic gonadotropin (hCG)

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Human chorionic gonadotropin is a glycoprotein hormone produced in pregnancy. Its role is to maintain progesterone production by preventing the disintegration of the corpus luteum of the ovary and thus sustain the growing foetus (Rull & Laan 2005). Gonadotropin comprises an alpha subunit (CGA), common to the pituitary gonadotropin hormones (LH, FSH and TSH) and a distinct beta subunit (CGB3), unique for each hormone which confers receptor and biological specificity. The subunits are bound by six intrachain disulfide bonds, required for dimer formation (Beebe et al. 1990)

Literature References

PubMed ID	Title	Journal	Year
16123088	Expression of beta-subunit of HCG genes during normal and failed pregnancy Laan, M, Rull, K	Hum. Reprod.	2005
1688430	Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form Perini, F, Ruddon, RW, Krzesicki, RF, Beebe, JS, Mountjoy, K	J Biol Chem	1990