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KS(2),C6S-ACAN(17-392) [extracellular region]
Stable Identifier
R-HSA-3791282
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Aggrecan degradation by ADAMTSs (Homo sapiens)
Aggrecan(17-392) [extracellular region] (Homo sapiens)
KS(2),C6S-ACAN(17-392) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16112 ACAN
Gene Names
ACAN, AGC1, CSPG1, MSK16
Chain
signal peptide:1-16, chain:17-2530, chain:393-2530
Reference Genes
BioGPS Gene:176 ACAN
COSMIC (genes):ACAN ACAN
CTD Gene:176 ACAN
dbSNP Gene:176 ACAN
ENSEMBL:ENSG00000157766 ACAN
HGNC:319 ACAN
KEGG:hsa:176 ACAN
Monarch:176 ACAN
NCBI Gene:176 ACAN
OMIM:155760 ACAN
UCSC:P16112 ACAN
Reference Transcript
RefSeq:XM_011521314.1 ACAN
RefSeq:NM_013227.3 ACAN
RefSeq:NM_001135.3 ACAN
Other Identifiers
11725358_a_at
11725359_a_at
11761169_at
11761170_at
1554950_PM_at
1554950_at
16804506
176
205679_PM_x_at
205679_x_at
207692_PM_s_at
207692_s_at
217161_PM_x_at
217161_x_at
3607333
3607334
3607335
3607336
3607337
3607338
3607351
3607352
3607354
3607355
3607356
3607357
3607358
3607359
3607362
3607363
3607364
3607365
3607366
3607367
3607368
3607369
3607370
3607371
3607372
3607373
3607374
3607375
3607376
3607377
3607378
3607379
3607380
3607381
3607383
3607384
3607385
3607386
3607388
3607389
3607390
3607393
3607394
3607395
3607396
38965_at
39206_s_at
39207_r_at
7985786
A_14_P133773
A_23_P307310
A_24_P919150
A_33_P3218741
A_33_P3500167
GE536916
GO:0001501
GO:0001502
GO:0002052
GO:0002063
GO:0005198
GO:0005201
GO:0005509
GO:0005515
GO:0005540
GO:0005576
GO:0005604
GO:0005615
GO:0005796
GO:0006508
GO:0007155
GO:0007417
GO:0007507
GO:0010001
GO:0012505
GO:0030021
GO:0030154
GO:0030166
GO:0030198
GO:0030199
GO:0030246
GO:0030312
GO:0031012
GO:0043202
GO:0045202
GO:0046872
GO:0048856
GO:0062023
GO:0072534
GO:0098966
GO:0098978
GO:0098982
GO:1901135
HMNXSV003038872
Hs2.407150.1.S1_3p_at
ILMN_1693148
ILMN_1740675
ILMN_1777182
M55172_at
PH_hs_0000285
TC15000842.hg
TC15000843.hg
TC15002348.hg
g4501990_3p_a_at
g6995993_3p_x_at
Participates
as a member of
Aggrecan(17-392) [extracellular region] (Homo sapiens)
Other forms of this molecule
KS(2)-ACAN [lysosomal lumen]
ACAN [lysosomal lumen]
KS(2)-ACAN [extracellular region]
KS(1)-ACAN [Golgi lumen]
KS(2)-ACAN [Golgi lumen]
Keratan(4)-ACAN [Golgi lumen]
Keratan(3)-ACAN [Golgi lumen]
Keratan(2)-ACAN [Golgi lumen]
Keratan(1)-ACAN [Golgi lumen]
Gal-glycan ACAN [Golgi lumen]
N-glycan ACAN [Golgi lumen]
KS(2),CSE-ACAN [extracellular region]
KS(2),C4S-ACAN [extracellular region]
KS(2),C6S-ACAN [extracellular region]
KS(2),C4S-ACAN(361-2415) [extracellular region]
KS(2),C6S-ACAN(361-2415) [extracellular region]
KS(2),CSE-ACAN(361-2415) [extracellular region]
KS(2),C6S-ACAN(17-360) [extracellular region]
KS(2),C4S-ACAN(17-360) [extracellular region]
KS(2),CSE-ACAN(17-360) [extracellular region]
KS(2),C6S-ACAN(17-375) [extracellular region]
KS(2),CSE-ACAN(17-375) [extracellular region]
KS(2),C4S-ACAN(17-375) [extracellular region]
KS(2),C6S-ACAN(376-2415) [extracellular region]
KS(2),CSE-ACAN(376-2415) [extracellular region]
KS(2),C4S-ACAN(376-2415) [extracellular region]
KS(2),C4S-ACAN(17-392) [extracellular region]
KS(2),CSE-ACAN(17-392) [extracellular region]
KS(2),C4S-ACAN(393-2415) [extracellular region]
KS(2),CSE-ACAN(393-2415) [extracellular region]
KS(2),C6S-ACAN(393-2415) [extracellular region]
Modified Residues
Name
N4-(N-acetylamino)glucosyl-L-asparagine (ChEBI:63520) at unknown position
Modification
alpha-NeuNAc-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal6S-(1->4)-beta-D-GlcNAc6S-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
O-xylosyl-L-serine (beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc6S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at unknown position
Modification
beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc6S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
OpenTargets
ENSG00000157766
ENSEMBL
ENSP00000453499
,
ENSP00000341615
,
ENST00000559004
,
ENST00000352105
,
ENST00000439576
,
ENSP00000387356
HPA
ENSG00000157766-ACAN
PRO
P16112
Pharos - Targets
P16112
GlyGen
P16112
Orphanet
ACAN
HMDB Protein
HMDBP01921
PDB
7RDV
,
4MD4
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
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