SLC6A3 cotransports DA, Na+ from extracellular region to cytosol

Stable Identifier
R-HSA-379393
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane, cytosol
Synonyms
Reuptake of dopamine from the synaptic cleft into neurons
ReviewStatus
5/5
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SLC6A3 cotransports DA, Na+ from extracellular region to cytosol
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The human gene SLC6A3 encodes the sodium-dependent dopamine transporter, DAT which mediates the re-uptake of dopamine from the synaptic cleft (Vandenbergh DJ et al, 2000). Dopamine can then be degraded by either COMT or monoamine oxidase.
Literature References
PubMed ID Title Journal Year
10889531 Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations

Thompson, MD, Cook, EH, Uhl, GR, Comings, D, O'Dowd, BF, Vandenbergh, DJ, Nguyen, T, George, SR, Tyndale, RF, Sellers, EM, Krasowski, MD, Zarrabian, D, Bendahhou, E

Mol Psychiatry 2000
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
dopamine uptake involved in synaptic transmission (0051583)
Catalyst Activity

monoamine transmembrane transporter activity of SLC6A3 [plasma membrane]

Physical Entity
SLC6A3 [plasma membrane] (Homo sapiens)
Activity
monoamine transmembrane transporter activity (GO:0008504)
Orthologous Events
SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Bos taurus)
SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Canis familiaris)
SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Danio rerio)
SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Drosophila melanogaster)
SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Mus musculus)
SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Plasmodium falciparum)
SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Rattus norvegicus)
SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Sus scrofa)
SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Xenopus tropicalis)
Authored
Mahajan, SS  (2008-06-26)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2008-10-18)
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