Reactome | TBCE [cytosol]

TBCE [cytosol]

Stable Identifier

R-HSA-379539

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tubulin-folding cofactor E

Locations in the PathwayBrowser for interactor UniProt:O60293 ZC3H1

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External Reference Information

External Reference

UniProt:Q15813 TBCE

Gene Names

TBCE

Chain

initiator methionine:, chain:2-527

Reference Genes

BioGPS Gene:6905 TBCE

COSMIC (genes):TBCE TBCE

CTD Gene:6905 TBCE

dbSNP Gene:6905 TBCE

ENSEMBL:ENSG00000284770 TBCE

ENSEMBL_homo_sapiens_GENE:ENSG00000284770.2 TBCE

HGNC:11582 TBCE

KEGG Gene (Homo sapiens):6905 TBCE

Monarch:6905 TBCE

NCBI Gene:6905 TBCE

OMIM:604934 TBCE

UCSC:Q15813 TBCE

Reference Transcript

Other Identifiers

11719854_a_at

11749261_a_at

16678966

203714_PM_s_at

203714_s_at

203715_PM_at

203715_at

2386400

2386401

2386402

2386403

2386410

2386427

2386428

2386430

2386431

2386432

2386434

2386435

2386438

2386444

2386446

2386447

2386448

2386452

2386453

2386456

2386458

2386463

2386464

2386465

2386468

2386469

2386472

2386474

2386475

2386476

2386481

2386483

2386484

2386486

2386488

35159_at

43787_at

6905

7910651

A_14_P112430

A_14_P123801

A_23_P52147

GE554391

GO:0000226

GO:0000278

GO:0003012

GO:0003735

GO:0005198

GO:0005515

GO:0005737

GO:0005840

GO:0005856

GO:0005874

GO:0006412

GO:0006457

GO:0007010

GO:0007021

GO:0007023

GO:0007052

GO:0007409

GO:0008092

GO:0008344

GO:0009791

GO:0014889

GO:0030154

GO:0043014

GO:0043226

GO:0048589

GO:0048856

GO:0048936

GO:0051087

GO:0065003

HMNXSV003051398

ILMN_2359014

PH_hs_0026057

TC01001945.hg

U61232_at

g6006029_3p_a_at

Participates

as an input of

as an output of

Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi (Homo sapiens)

as a component of

Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001072983.1, NP_001274731.1, NP_001274730.1, NP_003184.1

OpenTargets

ENSG00000284770

GeneCards

Q15813

HPA

ENSG00000285053-TBCE, ENSG00000284770-TBCE

Ensembl

ENSG00000284770, ENSP00000439170, ENSP00000495202, ENSG00000285053, ENSP00000494796, ENSP00000384571, ENST00000647186, ENSP00000494575, ENST00000645351, ENSP00000495823, ENSP00000494319, ENST00000543662, ENST00000645205, ENST00000406207, ENSP00000494775, ENST00000642610, ENST00000646624, ENST00000645655

PRO

Q15813

Pharos - Targets

Q15813

Orphanet

15581

PDB

4ICU, 4ICV

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60293 ZC3H1			0.527	2
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	2
UniProt:Q6UW10 SFTA2			0.527	2
UniProt:Q9H2M3 BHMT2	1	BHMT2 [cytosol] (R-HSA-5696831)	0.527	2
UniProt:P25963 NFKBIA	9	PolyUb-NFKBIA [cytosol] (R-HSA-6782960) NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805)	0.527	2
UniProt:P04798 CYP1A1	1	CYP1A1 [endoplasmic reticulum membrane] (R-HSA-52623)	0.527	2

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