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FARS2(1-?) [mitochondrial matrix]
Stable Identifier
R-HSA-379565
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
FARS2, Phenylalanyl-tRNA synthetase 2
Locations in the PathwayBrowser for interactor UniProt:O43609 SPRY1
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
tRNA Aminoacylation (Homo sapiens)
Mitochondrial tRNA aminoacylation (Homo sapiens)
phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate (Homo sapiens)
FARS2(1-?) [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95363 FARS2
Gene Names
FARS2, FARS1, HSPC320
Chain
transit peptide:1-, chain:-451
Reference Genes
BioGPS Gene:10667 FARS2
COSMIC (genes):FARS2 FARS2
CTD Gene:10667 FARS2
dbSNP Gene:10667 FARS2
ENSEMBL:ENSG00000145982 FARS2
HGNC:21062 FARS2
Monarch:10667 FARS2
NCBI Gene:10667 FARS2
OMIM:611592 FARS2
UCSC:O95363 FARS2
Reference Transcript
RefSeq:XM_017010186.1 FARS2
RefSeq:NM_001318872.1 FARS2
RefSeq:XM_017010187.1 FARS2
RefSeq:XM_005248812.3 FARS2
RefSeq:NM_006567.4 FARS2
Other Identifiers
10667
11744181_a_at
11744182_a_at
17004500
204282_PM_s_at
204282_s_at
204283_PM_at
204283_at
2893131
2893132
2893133
2893134
2893135
2893136
2893137
2893141
2893142
2893143
2893153
2893166
2893167
2893193
2893194
2893195
2893294
2893295
2893296
2893297
2893298
3504689
36504_at
8116724
A_14_P109146
A_14_P138976
A_23_P33720
GE54781
GO:0000049
GO:0000166
GO:0003723
GO:0003824
GO:0004812
GO:0004826
GO:0005515
GO:0005524
GO:0005737
GO:0005739
GO:0005759
GO:0006399
GO:0006412
GO:0006418
GO:0006432
GO:0006520
GO:0008033
GO:0016874
GO:0043039
GO:0043226
GO:0140098
HMNXSV003008253
HMNXSV003018077
HMNXSV003028482
ILMN_1793732
TC06000048.hg
g5729819_3p_a_at
Cross References
OpenTargets
ENSG00000145982
ENSEMBL
ENST00000274680
,
ENST00000324331
,
ENSP00000274680
,
ENSP00000316335
HPA
ENSG00000145982-FARS2
ZINC - Substances
SYFM_HUMAN
ZINC target
O95363
PRO
O95363
Pharos - Targets
O95363
Orphanet
FARS2
ZINC - Predictions - Purchasable
SYFM_HUMAN
HMDB Protein
HMDBP00275
PDB
3CMQ
,
8P8X
,
5MGH
,
5MGW
,
3HFV
,
3TEG
,
5MGU
,
3TUP
,
5MGV
Interactors (78)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UKG1 APPL1
1
APPL1 [endosome membrane]
(R-HSA-373630)
0.781
9
UniProt:Q13137 CACO2
0.781
7
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.718
6
UniProt:O95199 RCBT2
0.718
6
UniProt:P60411 KRTAP10-9
1
KRTAP10-9 [cytosol]
(R-HSA-6810277)
0.718
6
UniProt:Q9UKT9 IKZF3
0.718
6
UniProt:P60409 KRTAP10-7
1
KRTAP10-7 [cytosol]
(R-HSA-6810279)
0.718
6
UniProt:Q9UJV3-2 MID2
0.718
6
UniProt:Q8N9N5-2 BANP
0.601
4
UniProt:Q14353 GAMT
1
GAMT [cytosol]
(R-HSA-71276)
0.564
2
UniProt:P67809 YBX1
5
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
p-S32,S36-YBX1 [cytosol]
(R-HSA-9736837)
YBX1 [cytosol]
(R-HSA-9736840)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.564
2
UniProt:Q6RW13 AGTRAP
2
AGTRAP(1-159)-BRAF(288-545) fusion [cytosol]
(R-HSA-6802262)
AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol]
(R-HSA-6802511)
0.556
3
UniProt:Q6NT76 HMBX1
0.556
3
UniProt:Q6ZPD8 DGAT2L6
1
DGAT2L6 [endoplasmic reticulum membrane]
(R-HSA-8848588)
0.556
3
UniProt:Q10567-3 AP1B1
0.556
3
UniProt:Q96IF1 AJUBA
3
AJUBA [nucleoplasm]
(R-HSA-5687935)
p-S-AJUBA [cytosol]
(R-HSA-2574841)
AJUBA [cytosol]
(R-HSA-2564698)
0.556
3
UniProt:Q13064 MKRN3
0.556
3
UniProt:Q99750 MDFI
0.556
3
UniProt:Q9UFD9 RIM3A
0.556
3
UniProt:P07951-2 TPM2
0.556
3
UniProt:Q6PF18 MORN3
0.556
3
UniProt:Q12800 TFCP2
0.556
3
UniProt:Q9BYR6 KRTAP3-3
1
KRTAP3-3 [cytosol]
(R-HSA-6809859)
0.556
3
UniProt:Q9BYV9 BACH2
0.556
3
UniProt:Q9Y680 FKBP7
0.556
3
UniProt:Q9BXL8 CDCA4
0.556
3
UniProt:Q96DZ9-2 CMTM5
0.556
3
UniProt:Q96T49 PP16B
0.556
3
UniProt:Q8NI38 IKBD
0.556
3
IntAct:EBI-10171679 386682
0.556
3
UniProt:O60304 ZNF500
1
ZNF500 [nucleoplasm]
(R-HSA-1247856)
0.556
3
UniProt:Q07627 KRTAP1-1
1
KRTAP1-1 [cytosol]
(R-HSA-6809855)
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q9ULR0-1 Q9ULR01
0.556
3
UniProt:Q96DZ9 CKLF5
0.556
3
IntAct:EBI-16436244 CCSB ORF ID
0.556
3
UniProt:Q5TD97 FHL5
0.556
3
UniProt:Q9BQC3 DPH2
1
DPH2 [cytosol]
(R-HSA-5358368)
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.556
3
UniProt:A8MV81 HIGD1C
1
HIGD1C [mitochondrial inner membrane]
(R-HSA-9865734)
0.556
3
UniProt:O95429 BAG4
3
BAG4 [cytosol]
(R-HSA-5212670)
BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853156)
BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853157)
0.556
3
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
UniProt:Q7Z4V0 ZN438
0.556
3
UniProt:Q92997 DVL3
4
pp-DVL3 [cytosol]
(R-HSA-3772400)
p-DVL3 [cytosol]
(R-HSA-201680)
DVL3 [cytosol]
(R-HSA-201678)
ub-DVL3 [cytosol]
(R-HSA-4652688)
0.556
3
UniProt:P08247 SYP
1
SYP [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-5215991)
0.556
3
UniProt:Q5H9J7 BEX5
0.556
3
UniProt:Q14696 MESD
0.556
3
UniProt:Q8N720 ZNF655
1
ZNF655 [nucleoplasm]
(R-HSA-2127575)
0.556
3
UniProt:Q96N21 AP4AT
0.556
3
UniProt:O43609 SPRY1
3
p-Y53-SPRY1 [cytosol]
(R-HSA-182933)
SPRY1 [plasma membrane]
(R-HSA-182944)
SPRY1 [cytosol]
(R-HSA-182908)
0.556
3
UniProt:P60370 KRTAP10-5
1
KRTAP10-5 [cytosol]
(R-HSA-6810260)
0.556
3
UniProt:Q9H3M0 KCNF1
1
KCNF1 [plasma membrane]
(R-HSA-977450)
0.556
3
UniProt:Q9BYV2 TRI54
0.556
3
UniProt:A1A4E9 A1A4E9
0.556
3
UniProt:Q7Z3S9 NOTCH2NLA
3
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
NOTCH2NLA(1-?) [extracellular region]
(R-HSA-9911493)
NOTCH2NLA(?-236) [extracellular region]
(R-HSA-9911490)
0.556
3
UniProt:Q9NR34 MAN1C1
2
MAN1C1 [transport vesicle]
(R-HSA-8847483)
MAN1C1 [Golgi membrane]
(R-HSA-964742)
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:O95070 YIF1A
1
YIF1A [endoplasmic reticulum membrane]
(R-HSA-535599)
0.556
3
UniProt:O76011 KRT34
1
KRT34 [cytosol]
(R-HSA-6809608)
0.556
3
UniProt:Q13322-4 GRB10
0.556
3
UniProt:Q6RW13-2 AGTRAP
0.556
3
UniProt:Q4G0S7 CC152
0.556
3
UniProt:Q8TF50 ZN526
0.556
3
UniProt:A1L4K1 FSD2
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.556
3
UniProt:Q15654 TRIP6
0.556
3
UniProt:Q92824-2 PCSK5
0.556
3
UniProt:O75478 TADA2A
1
TADA2A [nucleoplasm]
(R-HSA-3662284)
0.556
3
UniProt:Q8NA61-2 CBY2
0.556
3
UniProt:O75558 STX11
0.556
3
UniProt:Q8N5Z5 KCD17
0.556
3
UniProt:Q02539 H1-1
1
HIST1H1A [nucleoplasm]
(R-HSA-211245)
0.527
3
UniProt:P10412 H1-4
1
HIST1H1E [nucleoplasm]
(R-HSA-211251)
0.527
2
UniProt:Q96DV4 MRPL38
1
MRPL38 [mitochondrial inner membrane]
(R-HSA-5368202)
0.527
2
UniProt:Q8TBF4 ZCRB1
2
ZCRB1 [cytosol]
(R-HSA-9682010)
ZCRB1 [nucleoplasm]
(R-HSA-6787853)
0.527
2
UniProt:P22492 H1T
0.527
3
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