Reactome | FARS2(1-?) [mitochondrial matrix]

FARS2(1-?) [mitochondrial matrix]

Stable Identifier

R-HSA-379565

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

FARS2, Phenylalanyl-tRNA synthetase 2

Locations in the PathwayBrowser for interactor UniProt:P08247 SYP

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External Reference Information

External Reference

UniProt:O95363 FARS2

Gene Names

FARS2, FARS1, HSPC320

Chain

transit peptide:1-, chain:-451

Reference Genes

BioGPS Gene:10667 FARS2

COSMIC (genes):FARS2 FARS2

CTD Gene:10667 FARS2

dbSNP Gene:10667 FARS2

ENSEMBL:ENSG00000145982 FARS2

ENSEMBL_homo_sapiens_GENE:ENSG00000145982.13 FARS2

HGNC:21062 FARS2

KEGG Gene (Homo sapiens):10667 FARS2

Monarch:10667 FARS2

NCBI Gene:10667 FARS2

OMIM:611592 FARS2

UCSC:O95363 FARS2

Reference Transcript

Other Identifiers

10667

11744181_a_at

11744182_a_at

17004500

204282_PM_s_at

204282_s_at

204283_PM_at

204283_at

2893131

2893132

2893134

2893135

2893136

2893137

2893141

2893142

2893153

2893166

2893167

2893193

2893194

2893195

36504_at

8116724

A_14_P109146

A_14_P138976

A_14_P201867

A_23_P33720

GE54781

GO:0000049

GO:0000166

GO:0003723

GO:0003824

GO:0004812

GO:0004826

GO:0005515

GO:0005524

GO:0005737

GO:0005739

GO:0005759

GO:0006399

GO:0006412

GO:0006418

GO:0006432

GO:0006520

GO:0008033

GO:0016874

GO:0043039

GO:0043226

GO:0140098

HMNXSV003008253

HMNXSV003018077

HMNXSV003028482

ILMN_1793732

TC06000048.hg

g5729819_3p_a_at

Cross References

RefSeq

NP_001305801.1, NP_006558.1, XP_016865676.1, XP_016865675.1, XP_005248869.1

OpenTargets

ENSG00000145982

ZINC - Substances

SYFM_HUMAN

ZINC target

O95363

PRO

O95363

PDB

3HFV, 5MGU, 8P8X, 5MGH, 3CMQ, 5MGW, 5MGV, 3TEG, 3TUP

HPA

ENSG00000145982-FARS2

GeneCards

O95363

Ensembl

ENSP00000274680, ENST00000324331, ENSP00000316335, ENST00000274680, ENSG00000145982

Pharos - Targets

O95363

Orphanet

21551

ZINC - Predictions - Purchasable

SYFM_HUMAN

HMDB Protein

HMDBP00275

Interactors (78)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13137 CACO2			0.781	7
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.781	9
UniProt:Q9UJV3-2 MID2			0.718	6
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.718	6
UniProt:Q9UKT9 IKZF3			0.718	6
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.718	6
UniProt:O95199 RCBT2			0.718	6
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.718	6
UniProt:Q8N9N5-2 BANP			0.601	4
UniProt:Q14353 GAMT	1	GAMT [cytosol] (R-HSA-71276)	0.564	2
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.564	2
UniProt:Q6RW13 AGTRAP	2	AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol] (R-HSA-6802511) AGTRAP(1-159)-BRAF(288-545) fusion [cytosol] (R-HSA-6802262)	0.556	3
UniProt:Q6NT76 HMBX1			0.556	3
UniProt:Q6ZPD8 DGAT2L6	1	DGAT2L6 [endoplasmic reticulum membrane] (R-HSA-8848588)	0.556	3
UniProt:Q10567-3 AP1B1			0.556	3
UniProt:Q96IF1 AJUBA	3	AJUBA [cytosol] (R-HSA-2564698) p-S-AJUBA [cytosol] (R-HSA-2574841) AJUBA [nucleoplasm] (R-HSA-5687935)	0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:Q99750 MDFI			0.556	3
UniProt:Q9UFD9 RIM3A			0.556	3
UniProt:P07951-2 TPM2			0.556	3
UniProt:Q6PF18 MORN3			0.556	3
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.556	3
UniProt:Q12800 TFCP2			0.556	3
UniProt:Q9BYR6 KRTAP3-3	1	KRTAP3-3 [cytosol] (R-HSA-6809859)	0.556	3
UniProt:Q9BYV9 BACH2			0.556	3
UniProt:Q9Y680 FKBP7			0.556	3
UniProt:Q9BXL8 CDCA4			0.556	3
UniProt:Q96DZ9-2 CMTM5			0.556	3
UniProt:Q96T49 PP16B			0.556	3
UniProt:Q8NI38 IKBD			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:O60304 ZNF500	1	ZNF500 [nucleoplasm] (R-HSA-1247856)	0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q9ULR0-1 Q9ULR01			0.556	3
UniProt:Q96DZ9 CKLF5			0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:Q5TD97 FHL5			0.556	3
UniProt:Q9BQC3 DPH2	1	DPH2 [cytosol] (R-HSA-5358368)	0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q8N5Z5 KCD17			0.556	3
UniProt:O75558 STX11			0.556	3
UniProt:Q8NA61-2 CBY2			0.556	3
UniProt:O75478 TADA2A	1	TADA2A [nucleoplasm] (R-HSA-3662284)	0.556	3
UniProt:Q92824-2 PCSK5			0.556	3
UniProt:Q15654 TRIP6			0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:A1L4K1 FSD2			0.556	3
UniProt:Q8TF50 ZN526			0.556	3
UniProt:Q4G0S7 CC152			0.556	3
UniProt:Q6RW13-2 AGTRAP			0.556	3
UniProt:Q13322-4 GRB10			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:Q9NR34 MAN1C1	2	MAN1C1 [transport vesicle] (R-HSA-8847483) MAN1C1 [Golgi membrane] (R-HSA-964742)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	1	NOTCH2NLA [extracellular region] (R-HSA-9908935)	0.556	3
UniProt:A1A4E9 A1A4E9			0.556	3
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:Q9H3M0 KCNF1	1	KCNF1 [plasma membrane] (R-HSA-977450)	0.556	3
UniProt:P60370 KRTAP10-5	1	KRTAP10-5 [cytosol] (R-HSA-6810260)	0.556	3
UniProt:O43609 SPRY1	3	p-Y53-SPRY1 [cytosol] (R-HSA-182933) SPRY1 [plasma membrane] (R-HSA-182944) SPRY1 [cytosol] (R-HSA-182908)	0.556	3
UniProt:Q96N21 AP4AT			0.556	3
UniProt:Q8N720 ZNF655	1	ZNF655 [nucleoplasm] (R-HSA-2127575)	0.556	3
UniProt:Q14696 MESD			0.556	3
UniProt:Q5H9J7 BEX5			0.556	3
UniProt:P08247 SYP	1	SYP [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-5215991)	0.556	3
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.556	3
UniProt:Q7Z4V0 ZN438			0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:A8MV81 HIGD1C	1	HIGD1C [mitochondrial inner membrane] (R-HSA-9865734)	0.556	3
UniProt:Q02539 H1-1	1	HIST1H1A [nucleoplasm] (R-HSA-211245)	0.527	3
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.527	2
UniProt:Q96DV4 MRPL38	1	MRPL38 [mitochondrial inner membrane] (R-HSA-5368202)	0.527	2
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	2
UniProt:P22492 H1T			0.527	3

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