Reactome | QARS [mitochondrial matrix]

QARS [mitochondrial matrix]

Stable Identifier

R-HSA-379592

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Glutaminyl-tRNA synthetase

Locations in the PathwayBrowser for interactor UniProt:P59942 MCCD1

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External Reference Information

External Reference

UniProt:P47897 QARS1

Gene Names

QARS1, QARS

Chain

initiator methionine:, chain:2-775

Reference Genes

BioGPS Gene:5859 QARS1

COSMIC (genes):QARS EPRS1

CTD Gene:5859 QARS1

dbSNP Gene:5859 QARS1

ENSEMBL:ENSG00000172053 QARS

HGNC:9751 QARS1

KEGG:hsa:5859 QARS1

Monarch:5859 QARS1

NCBI Gene:5859 QARS1

OMIM:603727 QARS1

UCSC:P47897 QARS1

Reference Transcript

Other forms of this molecule

QARS [cytosol]

Cross References

OpenTargets

ENSG00000172053

ENSEMBL

ENST00000414533, ENSP00000307567, ENSG00000172053, ENST00000306125, ENSP00000390015

ZINC - Substances

SYQ_HUMAN

ZINC target

P47897

PRO

P47897

GlyGen

P47897

PDB

4YE9, 4R3Z, 4YE8, 4YE6

IntEnz

6.1.1.18

GeneCards

QARS1

HPA

ENSG00000172053-QARS1

Pharos - Targets

P47897

Orphanet

QARS1

ZINC - Predictions - Purchasable

SYQ_HUMAN

HMDB Protein

HMDBP00580

Interactors (81)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y3C5 RNF11			0.83	10
UniProt:Q9BRK4 LZTS2			0.718	6
UniProt:Q9BUZ4 TRAF4			0.718	6
UniProt:Q15645 PCH2			0.718	6
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.706	18
UniProt:Q13155 AIMP2	1	AIMP2 [cytosol] (R-HSA-379576)	0.677	5
UniProt:Q99081 TCF12	1	TCF12 [nucleoplasm] (R-HSA-445670)	0.666	4
UniProt:Q9UPQ4-2 Q9UPQ42			0.601	4
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:Q7Z698 SPRED2	2	SPRED2 [cytosol] (R-HSA-5654211) SPRED2 [plasma membrane] (R-HSA-5658229)	0.556	3
UniProt:Q8IYI0 SHLD1			0.556	3
UniProt:O76013-2 KRT36			0.556	3
UniProt:Q9BPU9 B9D2	1	B9D2 [cytosol] (R-HSA-377736)	0.556	3
UniProt:P35609 ACTN2	3	ACTN2 [cytosol] (R-HSA-390562) ACTN2 [platelet alpha granule lumen] (R-HSA-349727) ACTN2 [extracellular region] (R-HSA-349725)	0.556	3
UniProt:Q9UJV3-2 MID2			0.556	3
UniProt:Q96F86 EDC3	1	EDC3 [cytosol] (R-HSA-429997)	0.556	3
UniProt:Q9H0C1 ZMY12			0.556	5
UniProt:Q86UY5 FAM83A	1	FAM83A [cytosol] (R-HSA-9851391)	0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:Q3B8N2 LEG9B			0.556	3
UniProt:Q7Z5V6-2 SAXO4			0.556	3
UniProt:Q8NI38 IKBD			0.556	3
UniProt:O60504 SORBS3	1	SORBS3 [cytosol] (R-HSA-445805)	0.556	3
UniProt:Q86UR1-2 NOXA1			0.556	3
UniProt:Q9NRI5-2 DISC1			0.556	3
UniProt:O43708 GSTZ1	2	GSTZ1 [cytosol] (R-HSA-71165) GSTZ1 [mitochondrial matrix] (R-HSA-9011574)	0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
UniProt:Q86WP2 GPBP1			0.556	3
UniProt:Q9Y2V7 COG6	2	COG6 [trans-Golgi network membrane] (R-HSA-6813872) COG6 [Golgi membrane] (R-HSA-2980958)	0.556	3
UniProt:Q9NQX0 PRDM6			0.556	3
UniProt:Q9H0A9-2 SPATC1L			0.556	3
UniProt:O76041 NEBL			0.556	3
UniProt:Q96DF8 ESS2			0.556	3
UniProt:P56545-3 CTBP2			0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q9BYE0 HES7	1	HES7 [nucleoplasm] (R-HSA-9824218)	0.556	3
UniProt:Q96CA5 BIRC7	1	BIRC7 [cytosol] (R-HSA-50855)	0.556	3
UniProt:Q8TDD2 SP7	1	SP7 [nucleoplasm] (R-HSA-8939843)	0.556	5
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:O75478 TADA2A	1	TADA2A [nucleoplasm] (R-HSA-3662284)	0.556	3
UniProt:P50570 DNM2	5	DNM2 [plasma membrane] (R-HSA-2984201) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [Golgi membrane] (R-HSA-2980842)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q13123 IK	1	IK [nucleoplasm] (R-HSA-9770239)	0.556	3
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:Q9H9H4 VPS37B	1	VPS37B [endosome membrane] (R-HSA-184293)	0.556	3
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.556	3
UniProt:Q14696 MESD			0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:Q13239-3 Q132393			0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:Q6DKI2 LEG9C			0.556	3
UniProt:Q5JST6 EFHC2			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:P59942 MCCD1			0.556	3
UniProt:Q6P597 KLC3	1	KLC3 [cytosol] (R-HSA-983232)	0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q96PF1 TGM7			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:Q9NP66 HM20A			0.556	3
UniProt:Q16825 PTN21			0.556	3
UniProt:A6NLX3 SPDE4			0.556	3
UniProt:P14868 DARS1	1	DARS [cytosol] (R-HSA-379605)	0.527	3
UniProt:P56192 MARS1	1	MARS [cytosol] (R-HSA-379657)	0.527	3
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.527	2
UniProt:P41252 IARS1	1	IARS [cytosol] (R-HSA-379641)	0.527	3
UniProt:P07814 EPRS1	1	EPRS [cytosol] (R-HSA-379649)	0.527	3
UniProt:Q9P2J5 LARS1	1	LARS [cytosol] (R-HSA-379680)	0.527	3
UniProt:Q12904 AIMP1	1	AIMP1(1-312) [cytosol] (R-HSA-379609)	0.527	3
UniProt:P54136 RARS1	1	RARS [cytosol] (R-HSA-379586)	0.527	3
UniProt:O43324 EEF1E1	1	EEF1E1 [cytosol] (R-HSA-379693)	0.527	3
UniProt:P35813 PPM1A	2	PPM1A [nucleoplasm] (R-HSA-205813) PPM1A [cytosol] (R-HSA-380928)	0.527	2
UniProt:P04591-PRO_0000038593 GAG			0.462	2

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