Reactome | QARS [mitochondrial matrix]

QARS [mitochondrial matrix]

Stable Identifier

R-HSA-379592

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Glutaminyl-tRNA synthetase

Locations in the PathwayBrowser for interactor UniProt:Q12904 AIMP1

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External Reference Information

External Reference

UniProt:P47897 QARS1

Gene Names

QARS1, QARS

Chain

initiator methionine:, chain:2-775

Reference Genes

BioGPS Gene:5859 QARS1

CTD Gene:5859 QARS1

dbSNP Gene:5859 QARS1

ENSEMBL:ENSG00000172053 QARS

ENSEMBL_homo_sapiens_GENE:ENSG00000172053.18 QARS1

HGNC:9751 QARS1

KEGG Gene (Homo sapiens):5859 QARS1

Monarch:5859 QARS1

NCBI Gene:5859 QARS1

OMIM:603727 QARS1

UCSC:P47897 QARS1

Reference Transcript

Other Identifiers

11719569_a_at

11747365_a_at

16953862

217846_PM_at

217846_at

2673938

2673939

2673940

2673944

2673946

2673947

2673949

2673952

2673954

2673955

2673956

2673957

2673958

2673959

2673962

2673963

2673964

2673966

2673967

2673968

2673969

2673970

2673972

2673973

2673975

2673976

2673978

2673980

2673981

2673983

2673984

5859

8087283

A_32_P532216

A_33_P3248644

GE60005

GO:0000166

GO:0003824

GO:0004812

GO:0004819

GO:0004860

GO:0005515

GO:0005524

GO:0005737

GO:0005739

GO:0005759

GO:0005829

GO:0006351

GO:0006355

GO:0006399

GO:0006412

GO:0006418

GO:0006425

GO:0006469

GO:0006520

GO:0007420

GO:0012501

GO:0016874

GO:0017101

GO:0019901

GO:0023052

GO:0032873

GO:0032991

GO:0036211

GO:0043039

GO:0043226

GO:0045892

GO:0048856

GO:0098772

GO:0140098

GO:2001234

HMNXSV003042530

ILMN_1763080

PH_hs_0004586

TC03001400.hg

X76013_at

g4826959_3p_at

Other forms of this molecule

QARS [cytosol]

Cross References

RefSeq

NP_005042.1, NP_001259002.1

OpenTargets

ENSG00000172053

ZINC - Substances

SYQ_HUMAN

ZINC target

P47897

PRO

P47897

PDB

4R3Z, 4YE6, 4YE8, 4YE9

HPA

ENSG00000172053-QARS1

GeneCards

P47897

Ensembl

ENSG00000172053, ENST00000414533, ENST00000306125, ENSP00000307567, ENSP00000390015

Pharos - Targets

P47897

ZINC - Predictions - Purchasable

SYQ_HUMAN

Orphanet

22969

HMDB Protein

HMDBP00580

Interactors (81)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y3C5 RNF11			0.83	10
UniProt:Q15645 PCH2			0.718	6
UniProt:Q9BUZ4 TRAF4			0.718	6
UniProt:Q9BRK4 LZTS2			0.718	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	18
UniProt:Q13155 AIMP2	1	AIMP2 [cytosol] (R-HSA-379576)	0.677	5
UniProt:Q99081 TCF12	1	TCF12 [nucleoplasm] (R-HSA-445670)	0.666	4
UniProt:Q9UPQ4-2 Q9UPQ42			0.601	4
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:Q7Z698 SPRED2	2	SPRED2 [cytosol] (R-HSA-5654211) SPRED2 [plasma membrane] (R-HSA-5658229)	0.556	3
UniProt:Q8IYI0 SHLD1			0.556	3
UniProt:O76013-2 KRT36			0.556	3
UniProt:Q9BPU9 B9D2	1	B9D2 [cytosol] (R-HSA-377736)	0.556	3
UniProt:P35609 ACTN2	3	ACTN2 [cytosol] (R-HSA-390562) ACTN2 [platelet alpha granule lumen] (R-HSA-349727) ACTN2 [extracellular region] (R-HSA-349725)	0.556	3
UniProt:Q9UJV3-2 MID2			0.556	3
UniProt:Q96F86 EDC3	1	EDC3 [cytosol] (R-HSA-429997)	0.556	3
UniProt:Q9H0C1 ZMY12			0.556	5
UniProt:Q86UY5 FAM83A	1	FAM83A [cytosol] (R-HSA-9851391)	0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:Q3B8N2 LEG9B			0.556	3
UniProt:Q7Z5V6-2 SAXO4			0.556	3
UniProt:Q8NI38 IKBD			0.556	3
UniProt:O60504 SORBS3	1	SORBS3 [cytosol] (R-HSA-445805)	0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:Q86UR1-2 NOXA1			0.556	3
UniProt:Q9NRI5-2 DISC1			0.556	3
UniProt:O43708 GSTZ1	2	GSTZ1 [cytosol] (R-HSA-71165) GSTZ1 [mitochondrial matrix] (R-HSA-9011574)	0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
UniProt:Q86WP2 GPBP1			0.556	3
UniProt:Q9Y2V7 COG6	2	COG6 [Golgi membrane] (R-HSA-2980958) COG6 [trans-Golgi network membrane] (R-HSA-6813872)	0.556	3
UniProt:Q9NQX0 PRDM6			0.556	3
UniProt:Q9H0A9-2 SPATC1L			0.556	3
UniProt:O76041 NEBL			0.556	3
UniProt:Q96DF8 ESS2			0.556	3
UniProt:P56545-3 CTBP2			0.556	3
UniProt:A6NLX3 SPDE4			0.556	3
UniProt:Q16825 PTN21			0.556	3
UniProt:Q9NP66 HM20A			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q96PF1 TGM7			0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q6P597 KLC3	1	KLC3 [cytosol] (R-HSA-983232)	0.556	3
UniProt:P59942 MCCD1			0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q5JST6 EFHC2			0.556	3
UniProt:Q6DKI2 LEG9C			0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:Q13239-3 Q132393			0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:Q14696 MESD			0.556	3
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.556	3
UniProt:Q9H9H4 VPS37B	1	VPS37B [endosome membrane] (R-HSA-184293)	0.556	3
UniProt:Q9BYE0 HES7	1	HES7 [nucleoplasm] (R-HSA-9824218)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q8TDD2 SP7	1	SP7 [nucleoplasm] (R-HSA-8939843)	0.556	5
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P98170 XIAP	3	XIAP [nucleoplasm] (R-HSA-3322366) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [cytosol] (R-HSA-50849)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:Q96CA5 BIRC7	1	BIRC7 [cytosol] (R-HSA-50855)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:Q13123 IK	1	IK [nucleoplasm] (R-HSA-9770239)	0.556	3
UniProt:O75478 TADA2A	1	TADA2A [nucleoplasm] (R-HSA-3662284)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:P50570 DNM2	5	DNM2 [Golgi membrane] (R-HSA-2980842) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [plasma membrane] (R-HSA-2984201)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:P14868 DARS1	1	DARS [cytosol] (R-HSA-379605)	0.527	3
UniProt:P56192 MARS1	1	MARS [cytosol] (R-HSA-379657)	0.527	3
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.527	2
UniProt:P41252 IARS1	1	IARS [cytosol] (R-HSA-379641)	0.527	3
UniProt:P07814 EPRS1	1	EPRS [cytosol] (R-HSA-379649)	0.527	3
UniProt:Q9P2J5 LARS1	1	LARS [cytosol] (R-HSA-379680)	0.527	3
UniProt:Q12904 AIMP1	1	AIMP1(1-312) [cytosol] (R-HSA-379609)	0.527	3
UniProt:P54136 RARS1	1	RARS [cytosol] (R-HSA-379586)	0.527	3
UniProt:O43324 EEF1E1	1	EEF1E1 [cytosol] (R-HSA-379693)	0.527	3
UniProt:P35813 PPM1A	2	PPM1A [cytosol] (R-HSA-380928) PPM1A [nucleoplasm] (R-HSA-205813)	0.527	2
UniProt:P04591-PRO_0000038593 GAG			0.462	2

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