Reactome | YARS2 [mitochondrial matrix]

YARS2 [mitochondrial matrix]

Stable Identifier

R-HSA-379634

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Tyrosyl-tRNA synthetase 2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y2Z4 YARS2

Gene Names

YARS2, CGI-04

Chain

transit peptide:1-16, chain:17-477

Reference Genes

BioGPS Gene:51067 YARS2

COSMIC (genes):YARS2 YARS2

CTD Gene:51067 YARS2

dbSNP Gene:51067 YARS2

ENSEMBL:ENSG00000139131 YARS2

ENSEMBL_homo_sapiens_GENE:ENSG00000139131.13 YARS2

HGNC:24249 YARS2

KEGG Gene (Homo sapiens):51067 YARS2

Monarch:51067 YARS2

NCBI Gene:51067 YARS2

OMIM:610957 YARS2

UCSC:Q9Y2Z4 YARS2

Reference Transcript

RefSeq:NM_001040436.2 YARS2

Other Identifiers

11720937_a_at

16763021

218470_PM_at

218470_at

3450202

3450203

3450204

3450205

3450206

3450207

3450210

3450211

3450212

3450213

3450214

3450215

3450216

44985_at

45688_at

51067

71128_r_at

7962203

A_23_P151093

GE58619

GO:0000049

GO:0000166

GO:0003723

GO:0003824

GO:0004812

GO:0004831

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005739

GO:0005759

GO:0005829

GO:0006399

GO:0006412

GO:0006418

GO:0006437

GO:0006520

GO:0016604

GO:0016874

GO:0042803

GO:0043039

GO:0043226

GO:0070184

GO:0072545

GO:0140053

GO:0140098

HMNXSV003016589

PH_hs_0024268

TC12001376.hg

Participates

as a component of

YARS2 dimer [mitochondrial matrix] (Homo sapiens)

Cross References

RefSeq

NP_001035526.1

OpenTargets

ENSG00000139131

GeneCards

Q9Y2Z4

HPA

ENSG00000139131-YARS2

Ensembl

ENSG00000139131, ENST00000324868, ENSP00000320658

PRO

Q9Y2Z4

Pharos - Targets

Q9Y2Z4

Orphanet

19339

HMDB Protein

HMDBP00619

PDB

3ZXI, 2PID

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.669	4
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171)	0.615	3
UniProt:Q6IN84 MRM1	1	MRM1 [mitochondrial matrix] (R-HSA-6793088)	0.527	2
UniProt:Q9UBU9 NXF1	2	NXF1 [cytosol] (R-HSA-156481) NXF1 [nucleoplasm] (R-HSA-111690)	0.527	2
UniProt:Q9NU23 LYRM2	1	LYRM2 [mitochondrial matrix] (R-HSA-9906752)	0.527	2

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