Reactome | VARS [cytosol]

VARS [cytosol]

Stable Identifier

R-HSA-379648

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Valyl-tRNA synthetase

Locations in the PathwayBrowser for interactor UniProt:P26641 EEF1G

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External Reference Information

External Reference

UniProt:P26640 VARS1

Gene Names

VARS1, G7A, VARS, VARS2

Chain

initiator methionine:, chain:2-1264

Reference Genes

BioGPS Gene:7407 VARS1

CTD Gene:7407 VARS1

dbSNP Gene:7407 VARS1

ENSEMBL:ENSG00000204394 VARS

ENSEMBL_homo_sapiens_GENE:ENSG00000096171.14 VARS1

ENSEMBL_homo_sapiens_GENE:ENSG00000204394.13 VARS1

ENSEMBL_homo_sapiens_GENE:ENSG00000224264.9 VARS1

ENSEMBL_homo_sapiens_GENE:ENSG00000226589.9 VARS1

ENSEMBL_homo_sapiens_GENE:ENSG00000231116.9 VARS1

HGNC:12651 VARS1

KEGG Gene (Homo sapiens):7407 VARS1

Monarch:7407 VARS1

NCBI Gene:7407 VARS1

OMIM:192150 VARS1

UCSC:P26640 VARS1

Reference Transcript

RefSeq:NM_006295.2 VARS1

Other Identifiers

11743987_a_at

11743988_x_at

11743989_a_at

11752554_a_at

17017428

17026808

17029281

17032067

17036785

17039552

17042060

201796_PM_s_at

201796_s_at

201797_PM_s_at

201797_s_at

2949381

2949382

2949385

2949387

2949388

2949390

2949391

2949392

2949393

2949394

2949395

2949397

2949399

2949400

2949402

2949403

2949405

2949407

2949408

2949410

2949411

2949412

2949413

2949414

2949415

2949416

2949417

2949418

2949420

2949422

2949423

2949424

2949427

2949428

40414_at

7407

8125091

8178609

A_23_P258714

A_33_P3248664

GE58396

GE59842

GO:0000166

GO:0002161

GO:0003824

GO:0004812

GO:0004832

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0006399

GO:0006412

GO:0006418

GO:0006438

GO:0006520

GO:0016787

GO:0016874

GO:0106074

GO:0140098

HMNXSV003007010

Hs.159637.0.S1_3p_a_at

ILMN_1696601

ILMN_1755507

ILMN_1772055

PH_hs_0027907

TC06001543.hg

TC6_apd_hap1000085.hg

TC6_cox_hap2000171.hg

TC6_dbb_hap3000160.hg

TC6_mcf_hap5000148.hg

TC6_qbl_hap6000161.hg

TC6_ssto_hap7000143.hg

X59303_s_at

g5454157_3p_a_at

Cross References

RefSeq

NP_006286.1

OpenTargets

ENSG00000204394

ZINC - Substances

SYVC_HUMAN

GeneCards

P26640

HPA

ENSG00000204394-VARS1

Ensembl

ENSP00000211402, ENSG00000204394, ENST00000435657, ENSG00000224264, ENST00000422694, ENSG00000226589, ENSP00000403359, ENST00000211402, ENSP00000401121, ENSG00000231116, ENST00000457796, ENSP00000415316, ENSP00000364815, ENST00000375663, ENSG00000096171

ZINC target

P26640

PRO

P26640

Pharos - Targets

P26640

Orphanet

23267

ZINC - Predictions - Purchasable

SYVC_HUMAN

HMDB Protein

HMDBP00651

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q05639 EEF1A2	1	EEF1A2 [cytosol] (R-HSA-3907261)	0.669	5
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.643	3
UniProt:P26641 EEF1G	3	EEF1G [cytosol] (R-HSA-156925) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839) EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (R-HSA-9710850)	0.643	4
UniProt:Q13554-3 CAMK2B			0.556	3
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [plasma membrane] (R-HSA-432796) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) CAMK2A [cytosol] (R-HSA-4332329) p-T286-CAMK2A [cytosol] (R-HSA-445368)	0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:P68104 EEF1A1	7	Me3K79-EEF1A1 [cytosol] (R-HSA-8932212) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [lysosomal membrane] (R-HSA-9626022)	0.527	4
UniProt:Q969K4 ABTB1			0.527	2
UniProt:P55198 AF17			0.527	3
UniProt:P15408 FOSL2			0.527	2
UniProt:P31146 CORO1A	1	CORO1A [cytosol] (R-HSA-9636432)	0.527	3
UniProt:P05412 JUN	4	p-S63,S73-JUN [cytosol] (R-HSA-8868682) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194)	0.462	3

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