Reactome | EPRS [cytosol]

EPRS [cytosol]

Stable Identifier

R-HSA-379649

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Bifunctional aminoacyl-tRNA synthetase

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P07814 EPRS1

Gene Names

EPRS1, EPRS, GLNS, PARS, QARS, QPRS, PIG32

Chain

chain:1-1512

Reference Genes

BioGPS Gene:2058 EPRS1

CTD Gene:2058 EPRS1

dbSNP Gene:2058 EPRS1

ENSEMBL:ENSG00000136628 EPRS

ENSEMBL_homo_sapiens_GENE:ENSG00000136628.18 EPRS1

HGNC:3418 EPRS1

KEGG Gene (Homo sapiens):2058 EPRS1

Monarch:2058 EPRS1

NCBI Gene:2058 EPRS1

OMIM:138295 EPRS1

UCSC:P07814 EPRS1

Reference Transcript

RefSeq:NM_004446.2 EPRS1

Other Identifiers

11715969_a_at

11715970_a_at

16699392

200841_PM_s_at

200841_s_at

200842_PM_s_at

200842_s_at

200843_PM_s_at

200843_s_at

2058

2456747

2456748

2456749

2456751

2456754

2456755

2456757

2456758

2456759

2456760

2456761

2456763

2456764

2456765

2456767

2456769

2456772

2456773

2456775

2456777

2456778

2456779

2456780

2456783

2456784

2456785

2456786

2456787

2456788

2456789

2456790

2456791

2456794

2456796

2456798

2456801

2456802

35300_at

7924351

A_23_P97632

GE59793

GO:0000166

GO:0002376

GO:0003723

GO:0003824

GO:0004812

GO:0004818

GO:0004827

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005886

GO:0006399

GO:0006412

GO:0006417

GO:0006418

GO:0006424

GO:0006433

GO:0006520

GO:0008152

GO:0008270

GO:0016020

GO:0016874

GO:0017101

GO:0017148

GO:0032869

GO:0035613

GO:0042802

GO:0042803

GO:0043039

GO:0046872

GO:0051020

GO:0065003

GO:0071346

GO:0097452

GO:0098542

GO:0140098

GO:0140212

GO:1990904

HMNXSV003001055

Hs.55921.0.S1_3p_a_at

Hs.55921.0.S2_3p_a_at

ILMN_1783695

PH_hs_0022831

TC01003833.hg

X54326_at

g4758293_3p_a_at

Participates

as a component of

Inferred To

proS [cytosol] (Dictyostelium discoideum)

EPRS [cytosol] (Drosophila melanogaster)

EPRS [cytosol] (Gallus gallus)

EPRS [cytosol] (Mus musculus)

Eprs1 [cytosol] (Rattus norvegicus)

EPRS1 [cytosol] (Bos taurus)

EPRS1 [cytosol] (Canis familiaris)

EPRS1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_004437.2

OpenTargets

ENSG00000136628

ZINC - Substances

SYEP_HUMAN

ZINC target

P07814

PRO

P07814

PDB

7OSY, 5BMU, 7OT0, 7BBU, 5A5H, 5A1N, 4HVC, 7X09, 7OSZ, 5V58, 7X1O, 6IY6, 7OT1, 7Y1H, 7OT3, 7F98, 7OT2, 5VAD, 5Y6L, 7Y1W, 1FYJ, 4K86, 7F99, 7Y28, 4K87, 7Y3S, 7F9B, 7F9A, 7F9D, 4K88, 7F9C, 5A34

IntEnz

6.1.1.15

HPA

ENSG00000136628-EPRS1

GeneCards

P07814

Ensembl

ENST00000366923, ENSP00000355890, ENSG00000136628

Pharos - Targets

P07814

Orphanet

26534

ZINC - Predictions - Purchasable

SYEP_HUMAN

HMDB Protein

HMDBP00567

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB(1-30) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.67	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	8
UniProt:P07900 HSP90AA1	8	HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.544	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3

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