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EPRS [cytosol]
Stable Identifier
R-HSA-379649
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Bifunctional aminoacyl-tRNA synthetase
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
MAPK-dependent phosphorylation of KARS (Homo sapiens)
KARS-depleted MSC [cytosol] (Homo sapiens)
EPRS [cytosol] (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
EPRS [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Selenoamino acid metabolism (Homo sapiens)
tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
EPRS [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
tRNA processing (Homo sapiens)
tRNA modification in the nucleus and cytosol (Homo sapiens)
DUS2:EPRS reduces uridine to dihydrouridine in tRNAs (Homo sapiens)
DUS2:EPRS [cytosol] (Homo sapiens)
EPRS [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
tRNA Aminoacylation (Homo sapiens)
Cytosolic tRNA aminoacylation (Homo sapiens)
arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
EPRS [cytosol] (Homo sapiens)
aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
EPRS [cytosol] (Homo sapiens)
glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)
EPRS [cytosol] (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
EPRS [cytosol] (Homo sapiens)
glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
EPRS [cytosol] (Homo sapiens)
isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
EPRS [cytosol] (Homo sapiens)
leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
EPRS [cytosol] (Homo sapiens)
lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
EPRS [cytosol] (Homo sapiens)
methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
EPRS [cytosol] (Homo sapiens)
proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate (Homo sapiens)
EPRS [cytosol] (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
EPRS [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07814 EPRS1
Gene Names
EPRS1, EPRS, GLNS, PARS, QARS, QPRS, PIG32
Chain
chain:1-1512
Reference Genes
BioGPS Gene:2058 EPRS1
CTD Gene:2058 EPRS1
dbSNP Gene:2058 EPRS1
ENSEMBL:ENSG00000136628 EPRS
ENSEMBL_homo_sapiens_GENE:ENSG00000136628.18 EPRS1
HGNC:3418 EPRS1
KEGG Gene (Homo sapiens):2058 EPRS1
Monarch:2058 EPRS1
NCBI Gene:2058 EPRS1
OMIM:138295 EPRS1
UCSC:P07814 EPRS1
Reference Transcript
RefSeq:NM_004446.2 EPRS1
Other Identifiers
11715969_a_at
11715970_a_at
16699392
200841_PM_s_at
200841_s_at
200842_PM_s_at
200842_s_at
200843_PM_s_at
200843_s_at
2058
2456747
2456748
2456749
2456751
2456754
2456755
2456757
2456758
2456759
2456760
2456761
2456763
2456764
2456765
2456767
2456769
2456772
2456773
2456775
2456777
2456778
2456779
2456780
2456783
2456784
2456785
2456786
2456787
2456788
2456789
2456790
2456791
2456794
2456796
2456798
2456801
2456802
35300_at
7924351
A_23_P97632
GE59793
GO:0000166
GO:0002376
GO:0003723
GO:0003824
GO:0004812
GO:0004818
GO:0004827
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0006399
GO:0006412
GO:0006417
GO:0006418
GO:0006424
GO:0006433
GO:0006520
GO:0008152
GO:0008270
GO:0016020
GO:0016874
GO:0017101
GO:0017148
GO:0032869
GO:0035613
GO:0042802
GO:0042803
GO:0043039
GO:0046872
GO:0051020
GO:0071346
GO:0097452
GO:0098542
GO:0140098
GO:0140212
GO:1990904
HMNXSV003001055
Hs.55921.0.S1_3p_a_at
Hs.55921.0.S2_3p_a_at
ILMN_1783695
PH_hs_0022831
TC01003833.hg
X54326_at
g4758293_3p_a_at
Participates
as a component of
DUS2:EPRS [cytosol] (Homo sapiens)
KARS-depleted MSC [cytosol] (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
Inferred To
proS [cytosol]
(Dictyostelium discoideum)
EPRS [cytosol]
(Drosophila melanogaster)
EPRS [cytosol]
(Gallus gallus)
EPRS [cytosol]
(Mus musculus)
Eprs1 [cytosol]
(Rattus norvegicus)
EPRS1 [cytosol]
(Bos taurus)
EPRS1 [cytosol]
(Canis familiaris)
EPRS1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_004437.2
OpenTargets
ENSG00000136628
ZINC - Substances
SYEP_HUMAN
ZINC target
P07814
PRO
P07814
PDB
7F98
,
5A5H
,
7F9C
,
7OT1
,
1FYJ
,
7Y28
,
5A1N
,
4HVC
,
7Y1W
,
7F99
,
7F9D
,
7Y3S
,
5V58
,
7OT2
,
5A34
,
7BBU
,
5VAD
,
7X1O
,
5Y6L
,
7F9A
,
7OSY
,
4K88
,
6IY6
,
7X09
,
7OT3
,
4K87
,
7Y1H
,
7OSZ
,
7F9B
,
4K86
,
7OT0
,
5BMU
IntEnz
6.1.1.15
GeneCards
P07814
HPA
ENSG00000136628-EPRS1
Ensembl
ENSG00000136628
,
ENST00000366923
,
ENSP00000355890
Pharos - Targets
P07814
ZINC - Predictions - Purchasable
SYEP_HUMAN
HMDB Protein
HMDBP00567
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IWL3 HSCB
5
HSCB [mitochondrial matrix]
(R-HSA-1299438)
HSCB(1-30) [mitochondrial matrix]
(R-HSA-8986120)
HSCB(1-235) [mitochondrial inner membrane]
(R-HSA-1299443)
HSCB [mitochondrial inner membrane]
(R-HSA-1299447)
HSCB(1-235) [mitochondrial intermembrane space]
(R-HSA-1299456)
0.67
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
8
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.544
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P47897 QARS1
2
QARS [cytosol]
(R-HSA-379615)
QARS [mitochondrial matrix]
(R-HSA-379592)
0.527
3
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