Reactome | MARS [cytosol]

MARS [cytosol]

Stable Identifier

R-HSA-379657

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Methionyl-tRNA synthetase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P56192 MARS1

Gene Names

MARS1, MARS

Chain

chain:1-900

Reference Genes

BioGPS Gene:4141 MARS1

CTD Gene:4141 MARS1

dbSNP Gene:4141 MARS1

ENSEMBL:ENSG00000166986 MARS

ENSEMBL:ENSG00000166986.15 MARS1

HGNC:6898 MARS1

KEGG Gene (Homo sapiens):4141 MARS1

Monarch:4141 MARS1

NCBI Gene:4141 MARS1

OMIM:156560 MARS1

UCSC:P56192 MARS1

Reference Transcript

RefSeq:NM_004990.3 MARS1

Other Identifiers

11744024_a_at

11746637_a_at

11755845_x_at

16752908

201475_PM_x_at

201475_x_at

213671_PM_s_at

213671_s_at

3418152

3418154

3418155

3418156

3418158

3418161

3418162

3418163

3418164

3418165

3418167

3418169

3418170

3418172

3418173

3418176

3418178

3418180

3418181

3418183

3418185

3418186

3418188

3418189

3418191

3418192

3418193

3418195

3418196

3418197

3418199

3418200

3418202

3418205

3418207

3418208

3418209

3418210

3418211

39342_at

4141

7956443

A_14_P118336

A_14_P127400

A_23_P128036

A_24_P175909

A_33_P3379377

GE674307

GE79201

GO:0000049

GO:0000166

GO:0003723

GO:0003824

GO:0004812

GO:0004825

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005730

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006399

GO:0006412

GO:0006418

GO:0006431

GO:0006520

GO:0009303

GO:0016020

GO:0016874

GO:0017101

GO:0036120

GO:0043226

GO:0070062

GO:0071364

GO:0140098

GO:1901838

HMNXSV003000138

ILMN_1799819

PH_hs_0018937

PH_hs_0023984

TC12000531.hg

X94754_at

g4826825_3p_s_at

Participates

as a component of

aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_004981.2

OpenTargets

ENSG00000166986

ZINC - Substances

SYMC_HUMAN

ZINC target

P56192

PRO

P56192

PDB

2DJV, 4BL7, 5GL7, 4BVY, 5Y6L, 5GOY, 4BVX

IntEnz

6.1.1.10

GeneCards

P56192

HPA

ENSG00000166986-MARS1

Ensembl

ENST00000537638, ENSG00000166986, ENSP00000446168, ENST00000262027, ENSP00000262027

Pharos - Targets

P56192

Orphanet

22571

ZINC - Predictions - Purchasable

SYMC_HUMAN

HMDB Protein

HMDBP00623

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	12
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.564	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3

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