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TAC1(98-107) [extracellular region]
Stable Identifier
R-HSA-380131
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Neurokinin A peptide, Protachykinin-1 precursor, TKN1_HUMAN, TAC1
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR2:TAC1(98-107) [plasma membrane] (Homo sapiens)
TAC1(98-107) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR2:TAC1(98-107) [plasma membrane] (Homo sapiens)
TAC1(98-107) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR2:TAC1(98-107) [plasma membrane] (Homo sapiens)
TAC1(98-107) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR2:TAC1(98-107) [plasma membrane] (Homo sapiens)
TAC1(98-107) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR2:TAC1(98-107) [plasma membrane] (Homo sapiens)
TAC1(98-107) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
TAC1(98-107) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Tachykinin receptors bind tachykinins (Homo sapiens)
Tachykinin receptor 2 (NK2) binds to nuerokinin A (Homo sapiens)
TAC1(98-107) [extracellular region] (Homo sapiens)
TACR2:TAC1(98-107) [plasma membrane] (Homo sapiens)
TAC1(98-107) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20366 TAC1
Gene Names
TAC1, NKA, NKNA, TAC2
Chain
signal peptide:1-19, propeptide:20-56, peptide:58-68, peptide:72-107, peptide:72-73, peptide:89-107, peptide:98-107, peptide:111-126
Reference Genes
BioGPS Gene:6863 TAC1
COSMIC (genes):TAC1 TAC1
CTD Gene:6863 TAC1
dbSNP Gene:6863 TAC1
ENSEMBL:ENSG00000006128 TAC1
ENSEMBL_homo_sapiens_GENE:ENSG00000006128.12 TAC1
HGNC:11517 TAC1
KEGG Gene (Homo sapiens):6863 TAC1
Monarch:6863 TAC1
NCBI Gene:6863 TAC1
OMIM:162320 TAC1
UCSC:P20366 TAC1
Reference Transcript
RefSeq:NM_013997.2 TAC1
RefSeq:NM_003182.2 TAC1
RefSeq:NM_013998.2 TAC1
RefSeq:NM_013996.2 TAC1
Other Identifiers
11728395_s_at
17048694
206552_PM_s_at
206552_s_at
3014067
3014068
3014069
3014070
3014073
3014075
3014078
3014079
3014080
3014081
36254_at
6863
8134420
A_23_P215283
A_24_P38290
GE59116
GO:0005576
GO:0005615
GO:0006954
GO:0007204
GO:0007217
GO:0007218
GO:0007267
GO:0007268
GO:0007320
GO:0009582
GO:0019233
GO:0022414
GO:0023052
GO:0030424
GO:0031835
GO:0043025
GO:0045202
GO:0048265
GO:0050877
GO:1990090
HMNXSV003048636
ILMN_1790270
ILMN_2342541
ILMN_2384409
M68907_s_at
PH_hs_0000343
PH_hs_0030888
TC07000579.hg
TC07002473.hg
U37529_at
g4507340_3p_a_at
Participates
as an input of
Tachykinin receptor 2 (NK2) binds to nuerokinin A (Homo sapiens)
as a member of
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
as a component of
TACR2:TAC1(98-107) [plasma membrane] (Homo sapiens)
Other forms of this molecule
TAC1(58-68) [extracellular region]
Inferred To
TAC1(98-107) [extracellular region]
(Sus scrofa)
TAC1 [extracellular region]
(Bos taurus)
TAC1 [extracellular region]
(Canis familiaris)
tac1 [extracellular region]
(Danio rerio)
tac1 [extracellular region]
(Gallus gallus)
Tac1 [extracellular region]
(Mus musculus)
Tac1 [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_054703.1
,
NP_054702.1
,
NP_054704.1
,
NP_003173.1
OpenTargets
ENSG00000006128
HPA
ENSG00000006128-TAC1
GeneCards
P20366
Ensembl
ENSP00000321106
,
ENST00000350485
,
ENSG00000006128
,
ENST00000346867
,
ENSP00000289576
,
ENSP00000289574
,
ENST00000319273
PRO
P20366
Pharos - Targets
P20366
PDB
2KS9
,
7VDM
,
8JBH
,
7RMG
,
2KSB
,
7P02
,
7XWO
,
7P00
,
2B19
,
8U26
,
2KSA
,
4HOM
,
7RMH
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