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TAC3 [extracellular region]
Stable Identifier
R-HSA-380133
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Neurokinin B peptide, Tachykinin-3 precursor, TKNK_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR3:TAC3 [plasma membrane] (Homo sapiens)
TAC3 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR3:TAC3 [plasma membrane] (Homo sapiens)
TAC3 [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR3:TAC3 [plasma membrane] (Homo sapiens)
TAC3 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR3:TAC3 [plasma membrane] (Homo sapiens)
TAC3 [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TACR3:TAC3 [plasma membrane] (Homo sapiens)
TAC3 [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
TAC3 [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Tachykinin receptors bind tachykinins (Homo sapiens)
Tachykinin receptor 3 (NK3) binds to neurokinin B (Homo sapiens)
TAC3 [extracellular region] (Homo sapiens)
TACR3:TAC3 [plasma membrane] (Homo sapiens)
TAC3 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UHF0 TAC3
Gene Names
TAC3, NKNB, UNQ585/PRO1155
Chain
signal peptide:1-16, propeptide:17-78, peptide:81-90, propeptide:94-121
Reference Genes
BioGPS Gene:6866 TAC3
COSMIC (genes):TAC3 TAC3
CTD Gene:6866 TAC3
dbSNP Gene:6866 TAC3
ENSEMBL:ENSG00000166863 TAC3
ENSEMBL_homo_sapiens_GENE:ENSG00000166863.13 TAC3
HGNC:11521 TAC3
KEGG Gene (Homo sapiens):6866 TAC3
Monarch:6866 TAC3
NCBI Gene:6866 TAC3
OMIM:162330 TAC3
UCSC:Q9UHF0 TAC3
Reference Transcript
RefSeq:NM_001178054.1 TAC3
RefSeq:NM_013251.3 TAC3
Other Identifiers
11729375_s_at
11729376_x_at
11753620_s_at
11760087_s_at
11762827_a_at
16766352
219992_PM_at
219992_at
3458231
3458234
3458235
3458236
3458237
3458238
3458239
3458240
3458241
3458243
3458244
3458252
3458253
55518_at
6866
7964303
A_23_P2283
GE79560
GO:0003013
GO:0005102
GO:0005515
GO:0005576
GO:0005615
GO:0007217
GO:0007218
GO:0007565
GO:0022414
GO:0023052
GO:0045777
HMNXSV003021337
ILMN_1784889
ILMN_1793006
ILMN_2406184
PH_hs_0001005
TC12002911.hg
TC12003219.hg
g7019576_3p_at
Participates
as an input of
Tachykinin receptor 3 (NK3) binds to neurokinin B (Homo sapiens)
as a member of
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
as a component of
TACR3:TAC3 [plasma membrane] (Homo sapiens)
Inferred To
tac3 [extracellular region]
(Xenopus tropicalis)
tac3a [extracellular region]
(Danio rerio)
LOC116183080 [extracellular region]
(Canis familiaris)
TAC3 [extracellular region]
(Bos taurus)
TAC3 [extracellular region]
(Sus scrofa)
Tac3 [extracellular region]
(Mus musculus)
Tac3 [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_001171525.1
,
NP_037383.1
OpenTargets
ENSG00000166863
GeneCards
Q9UHF0
HPA
ENSG00000166863-TAC3
Ensembl
ENSP00000377445
,
ENST00000458521
,
ENSP00000408131
,
ENSP00000368721
,
ENSP00000408208
,
ENSP00000300108
,
ENST00000379411
,
ENST00000423597
,
ENSG00000166863
,
ENST00000438756
,
ENST00000415231
,
ENST00000357616
,
ENST00000441881
,
ENSP00000402995
,
ENST00000393867
,
ENSP00000404056
,
ENSP00000416292
,
ENST00000300108
,
ENSP00000350236
PRO
Q9UHF0
Pharos - Targets
Q9UHF0
Orphanet
18060
PDB
1P9F
,
8JBG
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:A5D903 A5D903
0.556
3
UniProt:Q8WXH2 JPH3
0.556
3
UniProt:A0A087WZY1 A0A087WZY1
0.556
3
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