methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate

Stable Identifier
R-HSA-380157
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate
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MARS2 (mitochondrial methionyl tRNA synthetase) catalyzes the reaction of methionine, mitochondrial tRNA(Met), and ATP to form Met-tRNA(Met), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a monomer (Spencer et al. 2004).
Literature References
PubMed ID Title Journal Year
15274629 Characterization of the human mitochondrial methionyl-tRNA synthetase

Spencer, AC, Spremulli, LL, Heck, A, Takeuchi, N, Watanabe, K

Biochemistry 2004
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Catalyst Activity

methionine-tRNA ligase activity of MARS2 [mitochondrial matrix]

Physical Entity
MARS2 [mitochondrial matrix] (Homo sapiens)
Activity
methionine-tRNA ligase activity (GO:0004825)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-08)
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